U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Cep135 centrosomal protein 135 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305288, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Cep135provided by RGD
    Official Full Name
    centrosomal protein 135provided by RGD
    Primary source
    RGD:1310726
    See related
    EnsemblRapid:ENSRNOG00000002153 AllianceGenome:RGD:1310726
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310726
    Summary
    Predicted to enable microtubule binding activity and protein homodimerization activity. Predicted to be involved in centrosome cycle; positive regulation of establishment of protein localization; and positive regulation of non-motile cilium assembly. Predicted to be located in cytoplasm. Predicted to be active in centriole and centrosome. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 8. Orthologous to human CEP135 (centrosomal protein 135). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 52.5), Spleen (RPKM 39.7) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Cep135 in Genome Data Viewer
    Location:
    14p11
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (31884774..31950050, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (31530538..31595812, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (34052168..34115763, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096736 Neighboring gene capping protein inhibiting regulator of actin dynamics Neighboring gene ribosomal protein L23a, pseudogene 19 Neighboring gene exocyst complex component 1 Neighboring gene exocyst complex component 1 like

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A novel function of CEP135 as a platform protein of C-NAP1 for its centriolar localization. Kim K, et al. Exp Cell Res, 2008 Dec 10. PMID 18851962
    2. The conserved Wdr8-hMsd1/SSX2IP complex localises to the centrosome and ensures proper spindle length and orientation. Hori A, et al. Biochem Biophys Res Commun, 2015 Dec 4-11. PMID 26545777, Free PMC Article
    3. Plk4-induced centriole biogenesis in human cells. Kleylein-Sohn J, et al. Dev Cell, 2007 Aug. PMID 17681131
    4. CEP295 interacts with microtubules and is required for centriole elongation. Chang CW, et al. J Cell Sci, 2016 Jul 1. PMID 27185865, Free PMC Article
    5. ARFGAP1 promotes AP-2-dependent endocytosis. Bai M, et al. Nat Cell Biol, 2011 May. PMID 21499258, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centriole replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centriole-centriole cohesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of non-motile cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    centrosomal protein of 135 kDa
    Names
    centrosomal protein 135kDa

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398887.1 → NP_001385816.1  centrosomal protein of 135 kDa

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I6AQK7, D3ZI35
      Related
      ENSRNOP00000096498.2, ENSRNOT00000108575.2
      Conserved Domains (2) summary
      COG1196
      Location:202 → 994
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd22292
      Location:81 → 142
      cc_Cep135_MBD; coiled-coil microtubule binding domain of centrosomal protein of 135 kDa (Cep135) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      31884774..31950050 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250874.4 → XP_006250936.1  centrosomal protein of 135 kDa isoform X1

      See identical proteins and their annotated locations for XP_006250936.1

      UniProtKB/TrEMBL
      A0A8I6AQK7, D3ZI35
      Conserved Domains (2) summary
      COG1196
      Location:202 → 994
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd22292
      Location:81 → 142
      cc_Cep135_MBD; coiled-coil microtubule binding domain of centrosomal protein of 135 kDa (Cep135) and similar proteins

    2. XM_223341.10 → XP_223341.6  centrosomal protein of 135 kDa isoform X1

      See identical proteins and their annotated locations for XP_223341.6

      UniProtKB/TrEMBL
      A0A8I6AQK7, D3ZI35
      Conserved Domains (2) summary
      COG1196
      Location:202 → 994
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd22292
      Location:81 → 142
      cc_Cep135_MBD; coiled-coil microtubule binding domain of centrosomal protein of 135 kDa (Cep135) and similar proteins

    3. XM_039092701.2 → XP_038948629.1  centrosomal protein of 135 kDa isoform X2

      Conserved Domains (2) summary
      COG1196
      Location:202 → 950
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd22292
      Location:81 → 142
      cc_Cep135_MBD; coiled-coil microtubule binding domain of centrosomal protein of 135 kDa (Cep135) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous