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    FRS1 phenylalanine--tRNA ligase subunit beta [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850749, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FRS1
    Official Full Name
    phenylalanine--tRNA ligase subunit beta
    Primary source
    SGD:S000004050
    Locus tag
    YLR060W
    See related
    AllianceGenome:SGD:S000004050; FungiDB:YLR060W; VEuPathDB:YLR060W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables sequence-specific mRNA binding activity. Contributes to phenylalanine-tRNA ligase activity. Involved in phenylalanyl-tRNA aminoacylation. Located in cytoplasm. Part of phenylalanine-tRNA ligase complex. Orthologous to human FARSB (phenylalanyl-tRNA synthetase subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See FRS1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (260979..262766)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene glycine hydroxymethyltransferase SHM2 Neighboring gene Rex2p Neighboring gene ribosomal 60S subunit protein L22A Neighboring gene 25S rRNA (uracil2843-N3)-methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phenylalanyl-tRNA synthetase contains a dispensable RNA-binding domain that contributes to the editing of noncognate aminoacyl-tRNA. Roy H, et al. Biochemistry, 2006 Aug 1. PMID 16866361
    2. Editing of misaminoacylated tRNA controls the sensitivity of amino acid stress responses in Saccharomyces cerevisiae. Mohler K, et al. Nucleic Acids Res, 2017 Apr 20. PMID 28168297, Free PMC Article
    3. Identification of the major tRNA(Phe) binding domain in the tetrameric structure of cytoplasmic phenylalanyl-tRNA synthetase from baker's yeast. Fasiolo F, et al. FEBS Lett, 1989 Jan 2. PMID 2644133
    4. Modification of phenylalanyl-tRNA synthetase from baker's yeast by proteolytic cleavage and properties of the trypsin-modified enzyme. Fasiolo F, et al. Eur J Biochem, 1975 May 6. PMID 166841
    5. Design of a bacterial host for site-specific incorporation of p-bromophenylalanine into recombinant proteins. Kwon I, et al. J Am Chem Soc, 2006 Sep 13. PMID 16953616

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to phenylalanine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to phenylalanine-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phenylalanine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phenylalanyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phenylalanyl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phenylalanyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of phenylalanine-tRNA ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of phenylalanine-tRNA ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phenylalanine--tRNA ligase subunit beta
    NP_013161.1
    • Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase; forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      260979..262766
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181947.1 → NP_013161.1  TPA: phenylalanine--tRNA ligase subunit beta [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013161.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY62, E9P8X0, P15624
      UniProtKB/TrEMBL
      C8ZD32, G2WIQ3, N1NZH0
      Conserved Domains (1) summary
      TIGR00471
      Location:1 → 595
      pheT_arch; phenylalanyl-tRNA synthetase, beta subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P15624.3

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