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    ADE12 adenylosuccinate synthase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855501, updated on 9-Dec-2024

    Summary

    Official Symbol
    ADE12
    Official Full Name
    adenylosuccinate synthase
    Primary source
    SGD:S000005164
    Locus tag
    YNL220W
    See related
    AllianceGenome:SGD:S000005164; FungiDB:YNL220W; VEuPathDB:YNL220W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    BRA9
    Summary
    Enables DNA replication origin binding activity and adenylosuccinate synthase activity. Involved in purine nucleotide biosynthetic process. Located in cytoplasm. Orthologous to several human genes including ADSS2 (adenylosuccinate synthase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See ADE12 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (234413..235714)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ribonuclease P/MRP protein subunit POP1 Neighboring gene dolichyl-P-Man:Man(6)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase Neighboring gene ssDNA-dependent ATPase MGS1

    Bibliography

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA replication origin binding PubMed 
    enables GTP binding  
    enables adenylosuccinate synthase activity  
    enables adenylosuccinate synthase activity PubMed 
    enables adenylosuccinate synthase activity  
    enables adenylosuccinate synthase activity PubMed 
    enables ligase activity  
    enables magnesium ion binding  
    enables metal ion binding  
    Process Evidence Code Pubs
    involved_in 'de novo' AMP biosynthetic process  
    involved_in 'de novo' AMP biosynthetic process  
    involved_in IMP metabolic process  
    involved_in purine nucleotide biosynthetic process  
    involved_in purine nucleotide biosynthetic process PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm  

    General protein information

    Preferred Names
    adenylosuccinate synthase
    NP_014179.1
    • Adenylosuccinate synthase; catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      234413..235714
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183058.1 → NP_014179.1  TPA: adenylosuccinate synthase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014179.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZRM0, C7GPD7, D6W0X0, P80210
      UniProtKB/TrEMBL
      G2WLP3, N1NZ63
      Conserved Domains (1) summary
      pfam00709
      Location:4 → 428
      Adenylsucc_synt; Adenylosuccinate synthetase
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