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    COQ3 hexaprenyldihydroxybenzoate methyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854057, updated on 9-Dec-2024

    Summary

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    Official Symbol
    COQ3
    Official Full Name
    hexaprenyldihydroxybenzoate methyltransferase
    Primary source
    SGD:S000005456
    Locus tag
    YOL096C
    See related
    AllianceGenome:SGD:S000005456; FungiDB:YOL096C; VEuPathDB:YOL096C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity and 3-demethylubiquinol-n 3-O-methyltransferase activity. Involved in ubiquinone biosynthetic process. Located in mitochondrial inner membrane. Orthologous to human COQ3 (coenzyme Q3, methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See COQ3 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (138107..139045, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tryptophan--tRNA ligase WRS1 Neighboring gene ATP-dependent 3'-5' DNA helicase Neighboring gene replication factor C subunit 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ubiquinone biosynthesis in Saccharomyces cerevisiae. Isolation and sequence of COQ3, the 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase gene. Clarke CF, et al. J Biol Chem, 1991 Sep 5. PMID 1885593
    2. Mitochondrial acetyl-CoA utilization pathway for terpenoid productions. Yuan J, et al. Metab Eng, 2016 Nov. PMID 27471067
    3. Genetic evidence for coenzyme Q requirement in plasma membrane electron transport. Santos-Ocaña C, et al. J Bioenerg Biomembr, 1998 Oct. PMID 9932649
    4. Coq3p relevant residues for protein activity and stability. Paulela JA, et al. FEMS Yeast Res, 2021 Dec 7. PMID 34755843
    5. Complementation of coq3 mutant yeast by mitochondrial targeting of the Escherichia coli UbiG polypeptide: evidence that UbiG catalyzes both O-methylation steps in ubiquinone biosynthesis. Hsu AY, et al. Biochemistry, 1996 Jul 30. PMID 8703953

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Coq3p relevant residues for protein activity and stability.
      Title: Coq3p relevant residues for protein activity and stability.
    2. putative candidate for phosphorylation by Coq8p.
      Title: Ubiquinone biosynthesis in Saccharomyces cerevisiae: the molecular organization of O-methylase Coq3p depends on Abc1p/Coq8p.
    3. study identifies Coq3 peptide and Coq4 peptide as defining members of a Q-biosynthetic Coq polypeptide complex
      Title: Coq3 and Coq4 define a polypeptide complex in yeast mitochondria for the biosynthesis of coenzyme Q.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables 3-demethylubiquinol-n 3-O-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3-demethylubiquinol-n 3-O-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquinone biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ubiquinone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquinone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extrinsic component of mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    hexaprenyldihydroxybenzoate methyltransferase
    NP_014545.2
    • O-methyltransferase; catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      138107..139045 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183350.1 → NP_014545.2  TPA: hexaprenyldihydroxybenzoate methyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014545.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1X2, P27680
      UniProtKB/TrEMBL
      A6ZNB4, G2WMD9, N1NWB9
      Conserved Domains (1) summary
      TIGR01983
      Location:40 → 305
      UbiG; ubiquinone biosynthesis O-methyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27680.2

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