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    BUD5 Ras family guanine nucleotide exchange factor BUD5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850405, updated on 9-Dec-2024

    Summary

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    Official Symbol
    BUD5
    Official Full Name
    Ras family guanine nucleotide exchange factor BUD5
    Primary source
    SGD:S000000634
    Locus tag
    YCR038C
    See related
    AllianceGenome:SGD:S000000634; FungiDB:YCR038C; VEuPathDB:YCR038C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables guanyl-nucleotide exchange factor activity. Involved in axial cellular bud site selection and bipolar cellular bud site selection. Located in cellular bud neck and incipient cellular bud site. Human ortholog(s) of this gene implicated in hypertension; immunodeficiency 64; and platelet-type bleeding disorder 18. Orthologous to several human genes including RASGRP1 (RAS guanyl releasing protein 1); RASGRP2 (RAS guanyl releasing protein 2); and RASGRP3 (RAS guanyl releasing protein 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See BUD5 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (197621..199549, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene putative ribokinase Neighboring gene SPX domain-containing inorganic phosphate transporter Neighboring gene homeodomain mating type protein alpha2 Neighboring gene transcriptional co-activator mating type protein alpha Neighboring gene uncharacterized protein Neighboring gene Taf2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast BUD5, encoding a putative GDP-GTP exchange factor, is necessary for bud site selection and interacts with bud formation gene BEM1. Chant J, et al. Cell, 1991 Jun 28. PMID 1905981
    2. Development of pseudohyphae by embedded haploid and diploid yeast. Lo WS, et al. Curr Genet, 1997 Sep. PMID 9339344
    3. Specific residues of the GDP/GTP exchange factor Bud5p are involved in establishment of the cell type-specific budding pattern in yeast. Kang PJ, et al. J Biol Chem, 2004 Jul 2. PMID 15136576
    4. Cell polarity: connecting to the cortex. Arkowitz RA. Curr Biol, 2001 Aug 7. PMID 11516968
    5. A GDP/GTP exchange factor involved in linking a spatial landmark to cell polarity. Kang PJ, et al. Science, 2001 May 18. PMID 11313501, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axial cellular bud site selection IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in bipolar cellular bud site selection IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in incipient cellular bud site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ras family guanine nucleotide exchange factor BUD5
    NP_009967.2
    • GTP/GDP exchange factor for Rsr1p (Bud1p); required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      197621..199549 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178752.1 → NP_009967.2  TPA: Ras family guanine nucleotide exchange factor BUD5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009967.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR48, P25300, Q06729
      UniProtKB/TrEMBL
      A6ZTM0, C8Z4C8, G2WA56
      Conserved Domains (2) summary
      smart00147
      Location:409 → 640
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:230 → 339
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25300.2

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