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    sec24b SEC24 homolog B, COPII coat complex component [ Danio rerio (zebrafish) ]

    Gene ID: 334633, updated on 4-Jan-2025

    Summary

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    Official Symbol
    sec24bprovided by ZNC
    Official Full Name
    SEC24 homolog B, COPII coat complex componentprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6565
    See related
    Ensembl:ENSDARG00000071906 AllianceGenome:ZFIN:ZDB-GENE-030131-6565
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fa16f04
    Summary
    Predicted to enable SNARE binding activity and zinc ion binding activity. Predicted to be involved in COPII-coated vesicle cargo loading. Predicted to act upstream of or within endoplasmic reticulum to Golgi vesicle-mediated transport and intracellular protein transport. Predicted to be located in cytoplasmic vesicle; cytosol; and endoplasmic reticulum membrane. Predicted to be part of COPII vesicle coat. Predicted to be active in endoplasmic reticulum exit site. Orthologous to human SEC24B (SEC24 homolog B, COPII coat complex component). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See sec24b in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (1124464..1160573)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (1106143..1142307)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 16 member 2 Neighboring gene si:ch1073-303k11.2 Neighboring gene HOP homeobox Neighboring gene sperm microtubule associated protein 2 like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Mutations in the COPII vesicle component gene SEC24B are associated with human neural tube defects. Yang XY, et al. Hum Mutat, 2013 Aug. PMID 23592378
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in COPII-coated vesicle cargo loading IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of COPII vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COPII vesicle coat IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein transport protein Sec24B
    Names
    SEC24 family member B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      1124464..1160573
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001921599.8 → XP_001921634.3  protein transport protein Sec24B isoform X1

      UniProtKB/TrEMBL
      A0A8M1QLF8, E7F715
      Related
      ENSDARP00000097487.3, ENSDART00000106708.6
      Conserved Domains (6) summary
      COG5028
      Location:343 → 1175
      COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
      cd01479
      Location:591 → 834
      Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
      pfam00626
      Location:1055 → 1130
      Gelsolin; Gelsolin repeat
      pfam04810
      Location:518 → 554
      zf-Sec23_Sec24; Sec23/Sec24 zinc finger
      pfam04815
      Location:934 → 1028
      Sec23_helical; Sec23/Sec24 helical domain
      pfam08033
      Location:835 → 919
      Sec23_BS; Sec23/Sec24 beta-sandwich domain

    2. XM_005169568.5 → XP_005169625.1  protein transport protein Sec24B isoform X2

      UniProtKB/TrEMBL
      A0A2R8QCB9, A0A8M2BGZ1
      Related
      ENSDARP00000149303.1, ENSDART00000190043.1
      Conserved Domains (6) summary
      COG5028
      Location:256 → 1138
      COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
      cd01479
      Location:554 → 797
      Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
      pfam00626
      Location:1018 → 1093
      Gelsolin; Gelsolin repeat
      pfam04810
      Location:481 → 517
      zf-Sec23_Sec24; Sec23/Sec24 zinc finger
      pfam04815
      Location:897 → 991
      Sec23_helical; Sec23/Sec24 helical domain
      pfam08033
      Location:798 → 882
      Sec23_BS; Sec23/Sec24 beta-sandwich domain
    Nucleotide Protein Strain
    Heading Accession and Version

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