HNRNPD heterogeneous nuclear ribonucleoprotein D [Homo sapiens (human)] - Gene

Summary

Official Symbol: HNRNPDprovided by HGNC
Official Full Name: heterogeneous nuclear ribonucleoprotein Dprovided by HGNC
Primary source: HGNC:HGNC:5036
See related: Ensembl:ENSG00000138668 MIM:601324; AllianceGenome:HGNC:5036
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: P37; AUF1; AUF1A; HNRPD; hnRNPD0
Summary: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in lymph node (RPKM 80.4), bone marrow (RPKM 72.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 4q21.22

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (82352498..82373991, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (85681761..85703272, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (83273651..83295144, complement)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HNRNPD regulates the biogenesis of circRNAs and the ratio of mRNAs to circRNAs for a set of genes.
Title: HNRNPD regulates the biogenesis of circRNAs and the ratio of mRNAs to circRNAs for a set of genes.
CircUBE3A(2,3,4,5) promotes adenylate-uridylate-rich binding factor 1 nuclear translocation to suppress prostate cancer metastasis.
Title: CircUBE3A(2,3,4,5) promotes adenylate-uridylate-rich binding factor 1 nuclear translocation to suppress prostate cancer metastasis.
AUF1 Recognizes 8-Oxo-Guanosine Embedded in DNA and Stimulates APE1 Endoribonuclease Activity.
Title: AUF1 Recognizes 8-Oxo-Guanosine Embedded in DNA and Stimulates APE1 Endoribonuclease Activity.
AUF1-induced circular RNA hsa_circ_0010467 promotes platinum resistance of ovarian cancer through miR-637/LIF/STAT3 axis.
Title: AUF1-induced circular RNA hsa_circ_0010467 promotes platinum resistance of ovarian cancer through miR-637/LIF/STAT3 axis.
Expression of targets of the RNA-binding protein AUF-1 in human airway epithelium indicates its role in cellular senescence and inflammation.
Title: Expression of targets of the RNA-binding protein AUF-1 in human airway epithelium indicates its role in cellular senescence and inflammation.
AUF1 promotes hepatocellular carcinoma progression and chemo-resistance by post-transcriptionally upregulating alpha-fetoprotein expression.
Title: AUF1 promotes hepatocellular carcinoma progression and chemo-resistance by post-transcriptionally upregulating alpha-fetoprotein expression.
Circular RNA ARHGAP5 inhibits cisplatin resistance in cervical squamous cell carcinoma by interacting with AUF1.
Title: Circular RNA ARHGAP5 inhibits cisplatin resistance in cervical squamous cell carcinoma by interacting with AUF1.
Hsa_Circ_0000826 inhibits the proliferation of colorectal cancer by targeting AUF1.
Title: Hsa_Circ_0000826 inhibits the proliferation of colorectal cancer by targeting AUF1.
PUMILIO competes with AUF1 to control DICER1 RNA levels and miRNA processing.
Title: PUMILIO competes with AUF1 to control DICER1 RNA levels and miRNA processing.
The lncRNA THOR interacts with and stabilizes hnRNPD to promote cell proliferation and metastasis in breast cancer.
Title: The lncRNA THOR interacts with and stabilizes hnRNPD to promote cell proliferation and metastasis in breast cancer.

Submit: New GeneRIF Correction See all GeneRIFs (114)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein D (HNRNPD), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Envelope surface glycoprotein gp160, precursor	env	Depletion of hnRNP D decreases HIV-1 Env synthesis	PubMed
Gag-Pol	gag-pol	Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein D (HNRNPD), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Nef	nef	Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein D (HNRNPD), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Pr55(Gag)	gag	Depletion of hnRNP D reduces the accumulation of HIV-1 unspliced and singly spliced RNAs and decreases synthesis of HIV-1 Gag in the cytoplasm	PubMed
	gag	Overexpression of hnRNP D isoform d p37 and isoform c p40 suppress HIV-1 Gag synthesis, while overexpression of isoform a p45 and isoform b p42 increase HIV-1 Gag synthesis	PubMed
	gag	hnRNP D protein undergoes relocalization to the cytoplasm upon HIV-1 infection and is associated with HIV-1 Gag protein	PubMed
Rev	rev	HIV-1 Rev interacting protein, heterogeneous nuclear ribonucleoprotein D (HNRNPD), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with HNRNPD is increased by RRE	PubMed
Vpr	vpr	A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of heterogeneous nuclear ribonucleoprotein D (HNRNPD) expression by HIV-1 Vpr in Vpr transduced macrophages	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-24787 (e-PCR)
- UniSTS:8714

G33930 (e-PCR)
- UniSTS:2591

SHGC-67336 (e-PCR)
- UniSTS:89381

SHGC-67254 (e-PCR)
- UniSTS:89671

SHGC-59708 (e-PCR)
- UniSTS:85587

SHGC-67972 (e-PCR)
- UniSTS:60758

Hnrnpd (e-PCR), detects polymorphism
- UniSTS:516706

Hnrnpd (e-PCR), detects polymorphism
- UniSTS:516707

SHGC-31001 (e-PCR)
- UniSTS:73829

SHGC-51763 (e-PCR)
- UniSTS:28560

Hnrpd (e-PCR), detects polymorphism
- UniSTS:479121

RH136938 (e-PCR)
- UniSTS:219027

D4S1212 (e-PCR)
- UniSTS:23740

MARC_23646-23647:1029444341:1 (e-PCR)
- UniSTS:268733

MARC_23648-23649:1029444924:1 (e-PCR)
- UniSTS:268734

MARC_23650-23651:1029445581:1 (e-PCR)
- UniSTS:268735

SHGC-59507 (e-PCR)
- UniSTS:54464

STS-N23160 (e-PCR)
- UniSTS:27090

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	NAS Non-traceable Author Statement more info	PubMed
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR AU-rich region binding	IEA Inferred from Electronic Annotation more info
enables minor groove of adenine-thymine-rich DNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables telomeric DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA destabilization	IEA Inferred from Electronic Annotation more info
involved_in CRD-mediated mRNA stabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in RNA catabolic process	TAS Traceable Author Statement more info	PubMed
involved_in RNA processing	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to amino acid stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to estradiol stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to nitric oxide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to putrescine	IEA Inferred from Electronic Annotation more info
involved_in cerebellum development	IEA Inferred from Electronic Annotation more info
involved_in circadian regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hepatocyte dedifferentiation	IEA Inferred from Electronic Annotation more info
involved_in liver development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of cytoplasmic translation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of positive regulation of telomere capping	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of positive regulation of telomere maintenance via telomerase	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to calcium ion	IEA Inferred from Electronic Annotation more info
involved_in response to electrical stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to rapamycin	IEA Inferred from Electronic Annotation more info
involved_in response to sodium phosphate	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
part_of mCRD-mediated mRNA stability complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: heterogeneous nuclear ribonucleoprotein D0

Names: ARE-binding protein AUFI, type A; AU-rich RNA-binding factor 1; AU-rich element RNA binding protein 1, 37kDa; hnRNP D0

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029103.1 RefSeqGene

Range

5006..26499

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001003810.2 → NP_001003810.1 heterogeneous nuclear ribonucleoprotein D0 isoform d

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks two alternate in-frame segments, compared to variant 1. The resulting isoform (d), also known as p37, is shorter than isoform a.

Source sequence(s)

AC124016, AF039575, BC023977, BF693760, BG180865, BG180941, BG325979, BM832779

Consensus CDS

CCDS93554.1

UniProtKB/TrEMBL

B4DTC3

Related

ENSP00000422615.2, ENST00000503822.2

Conserved Domains (3) summary

cd12583
Location:164 → 238

RRM2_hnRNPD; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins

pfam08143
Location:60 → 78

CBFNT; CBFNT (NUC161) domain

cd12756
Location:80 → 153

RRM1_hnRNPD; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins
NM_002138.4 → NP_002129.2 heterogeneous nuclear ribonucleoprotein D0 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame segment, compared to variant 1. The resulting isoform (c), also known as p40, is shorter than isoform a.

Source sequence(s)

AC124016, AF039575, BC023977, BF693760, BM825808

Consensus CDS

CCDS3590.1

UniProtKB/TrEMBL

B4DTC3

Related

ENSP00000313327.6, ENST00000353341.8

Conserved Domains (3) summary

cd12583
Location:183 → 257

RRM2_hnRNPD; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins

pfam08143
Location:60 → 78

CBFNT; CBFNT (NUC161) domain

cd12756
Location:99 → 172

RRM1_hnRNPD; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins
NM_031369.3 → NP_112737.1 heterogeneous nuclear ribonucleoprotein D0 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1. The resulting isoform (b), also known as p42, is shorter than isoform a.

Source sequence(s)

AC124016, AF039575, BC002401, BC023977, BF693760, BG180865, BG180941, BG325979, BM832779

Consensus CDS

CCDS3591.1

UniProtKB/TrEMBL

B4DTC3

Related

ENSP00000305860.6, ENST00000352301.8

Conserved Domains (3) summary

cd12583
Location:164 → 238

RRM2_hnRNPD; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins

pfam08143
Location:60 → 78

CBFNT; CBFNT (NUC161) domain

cd12756
Location:80 → 153

RRM1_hnRNPD; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins
NM_031370.3 → NP_112738.1 heterogeneous nuclear ribonucleoprotein D0 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a), also known as p45.

Source sequence(s)

AC124016, AF039575, BC002401, BC023977, BF693760, BG180865, BG180941, BM825808, BM832779

Consensus CDS

CCDS3592.1

UniProtKB/Swiss-Prot

A8K9J2, P07029, Q01858, Q14100, Q14101, Q14102, Q14103, Q4W5A1, Q9UCE8, Q9UCE9

UniProtKB/TrEMBL

B4DTC3

Related

ENSP00000313199.7, ENST00000313899.12

Conserved Domains (3) summary

cd12583
Location:183 → 257

RRM2_hnRNPD; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins

pfam08143
Location:60 → 78

CBFNT; CBFNT (NUC161) domain

cd12756
Location:99 → 172

RRM1_hnRNPD; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins