U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ge-1 Ge-1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34541, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ge-1provided by FlyBase
    Official Full Name
    Ge-1provided by FlyBase
    Primary source
    FLYBASE:FBgn0283682
    Locus tag
    Dmel_CG6181
    See related
    AllianceGenome:FB:FBgn0283682
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6181; dGe-1; Dmel\CG6181; EDC4; GE-1; ref(2)M; Ref(2)Me
    Summary
    Involved in several processes, including P-body assembly; pole plasm oskar mRNA localization; and post-transcriptional regulation of gene expression. Located in P-body and pole plasm. Is expressed in several structures, including adult head; central brain primordium; embryonic central brain neurons; female germline cell; and ganglia. Orthologous to human EDC4 (enhancer of mRNA decapping 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ge-1 in Genome Data Viewer
    Location:
    32D3-32D3; 2-44 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11095150..11100888, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11095150..11100888, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene WD repeat domain 59 Neighboring gene RALBP1 associated Eps domain containing Neighboring gene lethal (2) giant discs 1 Neighboring gene alpha-L-iduronidase

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Why do Individuals Differ in Viral Susceptibility? A Story Told by Model Organisms. van Sluijs L, et al. Viruses, 2017 Sep 30. PMID 28973976, Free PMC Article
    2. The C-terminal region of Ge-1 presents conserved structural features required for P-body localization. Jinek M, et al. RNA, 2008 Oct. PMID 18755833, Free PMC Article
    3. [Drosophila genes which intervene in multiplication of sigma virus (author's transl)]. Gay P. Mol Gen Genet, 1978 Feb 27. PMID 416336
    4. HPat a decapping activator interacting with the miRNA effector complex. Barišić-Jäger E, et al. PLoS One, 2013. PMID 23977167, Free PMC Article
    5. HELZ directly interacts with CCR4-NOT and causes decay of bound mRNAs. Hanet A, et al. Life Sci Alliance, 2019 Oct. PMID 31570513, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we identified a deletion in the protein-coding region of a gene called Ge-1 in flies that are highly resistant to a naturally occurring virus called sigma virus
      Title: A Polymorphism in the Processing Body Component Ge-1 Controls Resistance to a Naturally Occurring Rhabdovirus in Drosophila.
    2. Findings suggest an important role of dGe-1 in optimization of the osk mRNA localization process required for patterning the Drosophila embryo.
      Title: Drosophila Ge-1 promotes P body formation and oskar mRNA localization.
    3. The three-dimensional crystal structure of the most conserved region of the Drosophila melanogaster Ge-1 C-terminal domain was determined.
      Title: The C-terminal region of Ge-1 presents conserved structural features required for P-body localization.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in P-body assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in deadenylation-independent decapping of nuclear-transcribed mRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in deadenylation-independent decapping of nuclear-transcribed mRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in miRNA-mediated post-transcriptional gene silencing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in pole plasm oskar mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in pole plasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Ge-1
    Names
    CG6181-PA
    CG6181-PB
    Ge-1 ortholog
    Ge-1-PA
    Ge-1-PB
    refractory to sigma M

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      11095150..11100888 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164957.2 → NP_723654.1  Ge-1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723654.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MZ42, Q9VKK1
      Related
      FBpp0079819
      Conserved Domains (3) summary
      pfam16529
      Location:119 → 452
      Ge1_WD40; WD40 region of Ge1, enhancer of mRNA-decapping protein
      sd00039
      Location:144 → 185
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:314 → 444
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_135642.3 → NP_609486.2  Ge-1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609486.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MZ42, Q9VKK1
      Related
      FBpp0079818
      Conserved Domains (3) summary
      pfam16529
      Location:119 → 452
      Ge1_WD40; WD40 region of Ge1, enhancer of mRNA-decapping protein
      sd00039
      Location:144 → 185
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:314 → 444
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VKK1.2 Q9VKK1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous