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    IPO4 importin 4 [ Homo sapiens (human) ]

    Gene ID: 79711, updated on 10-Dec-2024

    Summary

    Official Symbol
    IPO4provided by HGNC
    Official Full Name
    importin 4provided by HGNC
    Primary source
    HGNC:HGNC:19426
    See related
    Ensembl:ENSG00000196497 AllianceGenome:HGNC:19426
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Imp4
    Summary
    Enables nuclear import signal receptor activity and nuclear localization sequence binding activity. Involved in protein import into nucleus. Located in chromatin. Part of protein-containing complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 33.8), thyroid (RPKM 8.4) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See IPO4 in Genome Data Viewer
    Location:
    14q12
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (24180219..24188816, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (18378529..18387126, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24649425..24658022, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ring finger protein 31 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8191 Neighboring gene RNA, 5S ribosomal pseudogene 383 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8192 Neighboring gene interferon regulatory factor 9 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:24640701-24641201 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8193 Neighboring gene REC8 meiotic recombination protein Neighboring gene ReSE screen-validated silencer GRCh37_chr14:24657018-24657228 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5630 Neighboring gene transmembrane 9 superfamily member 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:24664227-24664926 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8194 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8195 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:24669563-24670500 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:24671230-24672429 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:24672535-24673433 Neighboring gene testis specific serine kinase 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    integrase gag-pol HIV-1 IN is identified to have a physical interaction with importin 4 (IPO4) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    General gene information

    Potential readthrough

    Included gene: TM9SF1

    Clone Names

    • FLJ23338, MGC131665

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity  
    enables nuclear import signal receptor activity PubMed 
    enables nuclear localization sequence binding  
    enables nuclear localization sequence binding PubMed 
    enables protein binding PubMed 
    enables small GTPase binding  
    Component Evidence Code Pubs
    located_in chromatin PubMed 
    is_active_in cytoplasm  
    located_in membrane PubMed 
    is_active_in nucleus  
    part_of protein-containing complex PubMed 

    General protein information

    Preferred Names
    importin-4
    Names
    imp4b
    importin-4b
    ran-binding protein 4
    ranBP4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024658.4 → NP_078934.3  importin-4

      See identical proteins and their annotated locations for NP_078934.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript.
      Source sequence(s)
      AK056527, AK094897, BC003690
      Consensus CDS
      CCDS9616.1
      UniProtKB/Swiss-Prot
      B2RN95, Q2NL96, Q86TZ9, Q8NCG8, Q8TEX9, Q96SJ3, Q9BTI4, Q9H5L0
      UniProtKB/TrEMBL
      B3KQ33
      Related
      ENSP00000346453.6, ENST00000354464.11
      Conserved Domains (4) summary
      smart00913
      Location:24 → 90
      IBN_N; Importin-beta N-terminal domain
      cd00020
      Location:355 → 467
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam13646
      Location:392 → 505
      HEAT_2; HEAT repeats
      sd00044
      Location:353 → 381
      HEAT; HEAT repeat [structural motif]

    RNA

    1. NR_051979.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate segment in the coding region, compared to variant 1, which results in a frameshift and early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK094897, BC144399
      Related
      ENST00000560155.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      24180219..24188816 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654722.1 Reference GRCh38.p14 PATCHES

      Range
      481197..489794 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      18378529..18387126 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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