Cd177 CD177 antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd177provided by MGI
Official Full Name: CD177 antigenprovided by MGI
Primary source: MGI:MGI:1916141
See related: Ensembl:ENSMUSG00000052212 AllianceGenome:MGI:1916141
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pdp3; 1190003K14Rik
Summary: Predicted to enable calcium-dependent protein binding activity; integrin binding activity; and protease binding activity. Predicted to be involved in several processes, including neutrophil extravasation; positive regulation of superoxide anion generation; and regulation of vesicle-mediated transport. Predicted to be located in plasma membrane and tertiary granule membrane. Predicted to be active in plasma membrane raft. Is expressed in bone marrow; liver; spleen; and thymus. Orthologous to human CD177 (CD177 molecule). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in colon adult (RPKM 70.2), liver E18 (RPKM 14.6) and 2 other tissues See more
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Genomic context

Location:: 7 A3; 7 12.58 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (24443408..24459759, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (24743983..24760334, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The link between neutrophils, NETs, and NLRP3 inflammasomes: The dual effect of CD177 and its therapeutic potential in acute respiratory distress syndrome/acute lung injury.
Title: The link between neutrophils, NETs, and NLRP3 inflammasomes: The dual effect of CD177 and its therapeutic potential in acute respiratory distress syndrome/acute lung injury.
CD177 on neutrophils engages stress-related behavioral changes in male mice.
Title: CD177 on neutrophils engages stress-related behavioral changes in male mice.
CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells.
Title: CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells.
CD177 expression in the gastric mucosa increases with the elevation of inflammation grade, which is higher in Helicobacter pylori- infected mice
Title: CD177 Expression and Inflammation Grade in Helicobacter pylori-Infected Wild-Type and CD177(-/-) C57BL/6 Mice.
Herein we established a novel genetic mouse model to study the role of CD177 and found that CD177 plays an important role in neutrophils.
Title: Characterization of a novel mouse model with genetic deletion of CD177.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion via plasma-membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion via plasma-membrane adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in cell-cell junction maintenance	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell junction maintenance	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in leukocyte cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in neutrophil extravasation	ISO Inferred from Sequence Orthology more info
involved_in neutrophil migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil degranulation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neutrophil degranulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of superoxide anion generation	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane raft	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane raft	ISO Inferred from Sequence Orthology more info
located_in secretory granule membrane	ISO Inferred from Sequence Orthology more info
located_in tertiary granule membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CD177 antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026862.4 → NP_081138.2 CD177 antigen precursor

See identical proteins and their annotated locations for NP_081138.2

Status: VALIDATED

Source sequence(s)

AC161488

Consensus CDS

CCDS20962.1

UniProtKB/Swiss-Prot

Q8R2S8

Related

ENSMUSP00000064934.6, ENSMUST00000063956.7

Conserved Domains (2) summary

pfam00021
Location:511 → 581

UPAR_LY6; u-PAR/Ly-6 domain

cl10471
Location:705 → 774

LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

24443408..24459759 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011250689.1 → XP_011248991.1 CD177 antigen isoform X3

Conserved Domains (1) summary

cl10471
Location:137 → 206

LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
XM_017312278.1 → XP_017167767.1 CD177 antigen isoform X2

Conserved Domains (1) summary

cl10471
Location:137 → 206

LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
XM_011250688.1 → XP_011248990.1 CD177 antigen isoform X1

Conserved Domains (1) summary

cl10471
Location:137 → 206

LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...