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    Dhx30 DExH-box helicase 30 [ Mus musculus (house mouse) ]

    Gene ID: 72831, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Dhx30provided by MGI
    Official Full Name
    DExH-box helicase 30provided by MGI
    Primary source
    MGI:MGI:1920081
    See related
    Ensembl:ENSMUSG00000032480 AllianceGenome:MGI:1920081
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HELG; Ddx30; Ret-CoR; 2810477H02Rik; C130058C04Rik
    Summary
    Enables RNA helicase activity. Involved in central nervous system development. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and integumental system. Orthologous to human DHX30 (DExH-box helicase 30). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in testis adult (RPKM 35.3), whole brain E14.5 (RPKM 33.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dhx30 in Genome Data Viewer
    Location:
    9 F2; 9 59.86 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (109913387..109946728, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (110084319..110117616, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25250 Neighboring gene STARR-positive B cell enhancer ABC_E9336 Neighboring gene predicted gene 4644 Neighboring gene microtubule-associated protein 4 Neighboring gene 60S ribosomal protein L7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_25252 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:109964958-109965201 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:109965464-109965647 Neighboring gene STARR-seq mESC enhancer starr_25254 Neighboring gene STARR-positive B cell enhancer ABC_E6806 Neighboring gene predicted gene 10615 Neighboring gene predicted gene, 23377 Neighboring gene STARR-seq mESC enhancer starr_25255 Neighboring gene SWI/SNF related BAF chromatin remodeling complex subunit C1 Neighboring gene STARR-seq mESC enhancer starr_25257

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. LncRNA Anxa10-203 enhances Mc1r mRNA stability to promote neuropathic pain by recruiting DHX30 in the trigeminal ganglion. Liu Y, et al. J Headache Pain, 2024 Mar 4. PMID 38433184, Free PMC Article
    2. The novel helicase helG (DHX30) is expressed during gastrulation in mice and has a structure similar to a human DExH box helicase. Zheng HJ, et al. Stem Cells Dev, 2015 Feb 1. PMID 25219788
    3. Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation. Watanabe A, et al. J Biol Chem, 2011 Mar 25. PMID 21266579, Free PMC Article
    4. TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation. Fan X, et al. Elife, 2021 Feb 8. PMID 33554859, Free PMC Article
    5. Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST. Nakano Y, et al. Cell Rep, 2019 Apr 16. PMID 30995482, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA Anxa10-203 enhances Mc1r mRNA stability to promote neuropathic pain by recruiting DHX30 in the trigeminal ganglion.
      Title: LncRNA Anxa10-203 enhances Mc1r mRNA stability to promote neuropathic pain by recruiting DHX30 in the trigeminal ganglion.
    2. An improved gene trap method "trapped" a helG gene expressed in mouse ES cells. The helG product shared a high level of homology with the DExH RNA helicase family. It is required for differentiation during embryogenesis.
      Title: The novel helicase helG (DHX30) is expressed during gastrulation in mice and has a structure similar to a human DExH box helicase.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1)  1 citation
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G-quadruplex RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in central nervous system development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial large ribosomal subunit assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial large ribosomal subunit assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial nucleoid ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ribonucleoprotein granule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent RNA helicase DHX30
    Names
    DEAH (Asp-Glu-Ala-His) box polypeptide 30
    DEAH box protein 30
    putative ATP-dependent RNA helicase DHX30
    NP_001239611.1
    NP_001239612.1
    NP_579925.1
    XP_006512361.1
    XP_006512362.1
    XP_006512363.1
    XP_006512364.1
    XP_006512366.1
    XP_006512367.1
    XP_006512368.1
    XP_006512373.1
    XP_017169103.1
    XP_017169104.1
    XP_030100501.1
    XP_030100502.1
    XP_030100503.1
    XP_030100504.1
    XP_030100506.1
    XP_030100507.1
    XP_036011214.1
    XP_036011215.1
    XP_036011216.1
    XP_036011218.1
    XP_036011219.1
    XP_036011220.1
    XP_036011221.1
    XP_036011222.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252682.1 → NP_001239611.1  ATP-dependent RNA helicase DHX30 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the shortest isoform (1).
      Source sequence(s)
      AC159372, AK159601, BY540912, CF724787
      Consensus CDS
      CCDS57706.1
      UniProtKB/TrEMBL
      Q80TP6
      Related
      ENSMUSP00000142549.2, ENSMUST00000197928.5
      Conserved Domains (1) summary
      COG1643
      Location:423 → 1072
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    2. NM_001252683.1 → NP_001239612.1  ATP-dependent RNA helicase DHX30 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is longer and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      BC016202, BY540912, CJ074324
      Consensus CDS
      CCDS57705.1
      UniProtKB/Swiss-Prot
      Q99PU8
      Related
      ENSMUSP00000062622.7, ENSMUST00000062368.13
      Conserved Domains (5) summary
      smart00490
      Location:715 → 814
      HELICc; helicase superfamily c-terminal domain
      smart00487
      Location:467 → 646
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:886 → 969
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:481 → 622
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam07717
      Location:1009 → 1131
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    3. NM_133347.2 → NP_579925.1  ATP-dependent RNA helicase DHX30 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is longer and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AB047557, BY540912
      Consensus CDS
      CCDS23560.1
      UniProtKB/Swiss-Prot
      Q3U4Z4, Q3UFA0, Q3UJS4, Q91WA7, Q99KN7, Q99PU8
      UniProtKB/TrEMBL
      Q80TP6
      Related
      ENSMUSP00000129174.2, ENSMUST00000165596.8
      Conserved Domains (1) summary
      COG1643
      Location:446 → 1095
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      109913387..109946728 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512305.5 → XP_006512368.1  ATP-dependent RNA helicase DHX30 isoform X2

      UniProtKB/TrEMBL
      Q80TP6
      Conserved Domains (1) summary
      COG1643
      Location:423 → 1072
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    2. XM_036155326.1 → XP_036011219.1  ATP-dependent RNA helicase DHX30 isoform X2

      UniProtKB/TrEMBL
      Q80TP6
      Related
      ENSMUSP00000107622.3, ENSMUST00000111991.9
      Conserved Domains (1) summary
      COG1643
      Location:423 → 1072
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    3. XM_036155325.1 → XP_036011218.1  ATP-dependent RNA helicase DHX30 isoform X2

      UniProtKB/TrEMBL
      Q80TP6
      Conserved Domains (1) summary
      COG1643
      Location:423 → 1072
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    4. XM_036155328.1 → XP_036011221.1  ATP-dependent RNA helicase DHX30 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JGL8, Q80TP6
      Related
      ENSMUSP00000143616.2, ENSMUST00000196171.5
      Conserved Domains (1) summary
      COG1643
      Location:415 → 1064
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    5. XM_006512301.5 → XP_006512364.1  ATP-dependent RNA helicase DHX30 isoform X1

      UniProtKB/Swiss-Prot
      Q3U4Z4, Q3UFA0, Q3UJS4, Q91WA7, Q99KN7, Q99PU8
      UniProtKB/TrEMBL
      Q80TP6
      Conserved Domains (1) summary
      COG1643
      Location:446 → 1095
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    6. XM_036155329.1 → XP_036011222.1  ATP-dependent RNA helicase DHX30 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JGL8, Q80TP6
      Conserved Domains (1) summary
      COG1643
      Location:415 → 1064
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    7. XM_030244644.2 → XP_030100504.1  ATP-dependent RNA helicase DHX30 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JGL8, Q80TP6
      Conserved Domains (1) summary
      COG1643
      Location:415 → 1064
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    8. XM_006512310.5 → XP_006512373.1  ATP-dependent RNA helicase DHX30 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JGL8, Q80TP6
      Conserved Domains (1) summary
      COG1643
      Location:415 → 1064
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    9. XM_036155321.1 → XP_036011214.1  ATP-dependent RNA helicase DHX30 isoform X1

      UniProtKB/Swiss-Prot
      Q3U4Z4, Q3UFA0, Q3UJS4, Q91WA7, Q99KN7, Q99PU8
      UniProtKB/TrEMBL
      Q80TP6
      Conserved Domains (1) summary
      COG1643
      Location:446 → 1095
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    10. XM_036155323.1 → XP_036011216.1  ATP-dependent RNA helicase DHX30 isoform X2

      UniProtKB/TrEMBL
      Q80TP6
      Related
      ENSMUSP00000142489.2, ENSMUST00000199529.5
      Conserved Domains (1) summary
      COG1643
      Location:423 → 1072
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    11. XM_030244642.2 → XP_030100502.1  ATP-dependent RNA helicase DHX30 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JGL8, Q80TP6
      Conserved Domains (1) summary
      COG1643
      Location:415 → 1064
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    12. XM_006512298.5 → XP_006512361.1  ATP-dependent RNA helicase DHX30 isoform X1

      UniProtKB/Swiss-Prot
      Q3U4Z4, Q3UFA0, Q3UJS4, Q91WA7, Q99KN7, Q99PU8
      UniProtKB/TrEMBL
      Q80TP6
      Related
      ENSMUSP00000142659.2, ENSMUST00000198425.5
      Conserved Domains (1) summary
      COG1643
      Location:446 → 1095
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    13. XM_017313614.2 → XP_017169103.1  ATP-dependent RNA helicase DHX30 isoform X1

      UniProtKB/Swiss-Prot
      Q3U4Z4, Q3UFA0, Q3UJS4, Q91WA7, Q99KN7, Q99PU8
      UniProtKB/TrEMBL
      Q80TP6
      Conserved Domains (1) summary
      COG1643
      Location:446 → 1095
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    14. XM_030244641.2 → XP_030100501.1  ATP-dependent RNA helicase DHX30 isoform X2

      UniProtKB/TrEMBL
      Q80TP6
      Conserved Domains (1) summary
      COG1643
      Location:423 → 1072
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    15. XM_036155327.1 → XP_036011220.1  ATP-dependent RNA helicase DHX30 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JGL8, Q80TP6
      Conserved Domains (1) summary
      COG1643
      Location:415 → 1064
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    16. XM_006512299.3 → XP_006512362.1  ATP-dependent RNA helicase DHX30 isoform X1

      UniProtKB/Swiss-Prot
      Q3U4Z4, Q3UFA0, Q3UJS4, Q91WA7, Q99KN7, Q99PU8
      UniProtKB/TrEMBL
      Q80TP6
      Conserved Domains (1) summary
      COG1643
      Location:446 → 1095
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    17. XM_030244646.2 → XP_030100506.1  ATP-dependent RNA helicase DHX30 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JGL8, Q80TP6
      Conserved Domains (1) summary
      COG1643
      Location:415 → 1064
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    18. XM_006512303.3 → XP_006512366.1  ATP-dependent RNA helicase DHX30 isoform X2

      UniProtKB/TrEMBL
      Q80TP6
      Related
      ENSMUSP00000143371.2, ENSMUST00000200066.5
      Conserved Domains (1) summary
      COG1643
      Location:423 → 1072
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    19. XM_017313615.2 → XP_017169104.1  ATP-dependent RNA helicase DHX30 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JGL8, Q80TP6
      Conserved Domains (1) summary
      COG1643
      Location:415 → 1064
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    20. XM_036155322.1 → XP_036011215.1  ATP-dependent RNA helicase DHX30 isoform X1

      UniProtKB/Swiss-Prot
      Q3U4Z4, Q3UFA0, Q3UJS4, Q91WA7, Q99KN7, Q99PU8
      UniProtKB/TrEMBL
      Q80TP6
      Conserved Domains (1) summary
      COG1643
      Location:446 → 1095
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    21. XM_006512300.3 → XP_006512363.1  ATP-dependent RNA helicase DHX30 isoform X1

      UniProtKB/Swiss-Prot
      Q3U4Z4, Q3UFA0, Q3UJS4, Q91WA7, Q99KN7, Q99PU8
      UniProtKB/TrEMBL
      Q80TP6
      Conserved Domains (1) summary
      COG1643
      Location:446 → 1095
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    22. XM_030244647.1 → XP_030100507.1  ATP-dependent RNA helicase DHX30 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JGL8, Q80TP6
      Conserved Domains (1) summary
      COG1643
      Location:415 → 1064
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    23. XM_006512304.1 → XP_006512367.1  ATP-dependent RNA helicase DHX30 isoform X2

      UniProtKB/TrEMBL
      Q80TP6
      Conserved Domains (1) summary
      COG1643
      Location:423 → 1072
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    24. XM_030244643.1 → XP_030100503.1  ATP-dependent RNA helicase DHX30 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JGL8, Q80TP6
      Conserved Domains (1) summary
      COG1643
      Location:415 → 1064
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99PU8.1 GenPept UniProtKB/Swiss-Prot:Q99PU8

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