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    Atxn2l ataxin 2-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361649, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Atxn2lprovided by RGD
    Official Full Name
    ataxin 2-likeprovided by RGD
    Primary source
    RGD:1565868
    See related
    EnsemblRapid:ENSRNOG00000018686 AllianceGenome:RGD:1565868
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565868
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in mRNA metabolic process and stress granule assembly. Predicted to be located in cytosol; membrane; and nuclear speck. Predicted to be active in cytoplasmic stress granule. Orthologous to human ATXN2L (ataxin 2 like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 97.4), Spleen (RPKM 87.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Atxn2l in Genome Data Viewer
    Location:
    1q36
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (190508878..190526263, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (181078293..181090079, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (197908087..197920400, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene SH2B adaptor protein 1 Neighboring gene Tu translation elongation factor, mitochondrial Neighboring gene uncharacterized LOC134483838 Neighboring gene metallothionein 1, pseudogene 1 Neighboring gene eukaryotic translation initiation factor 3, subunit C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Ataxin-2-like is a regulator of stress granules and processing bodies. Kaehler C, et al. PLoS One, 2012. PMID 23209657, Free PMC Article
    2. Cloning and characterization of a family of proteins associated with Mpl. Meunier C, et al. J Biol Chem, 2002 Mar 15. PMID 11784712
    3. Mapping the in vitro interactome of cardiac sodium (Na(+) )-calcium (Ca(2+) ) exchanger 1 (NCX1). Lubelwana Hafver T, et al. Proteomics, 2017 Sep. PMID 28755400
    4. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
    5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stress granule assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ataxin-2-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130097.3 → NP_001123569.2  ataxin-2-like protein isoform 1

      See identical proteins and their annotated locations for NP_001123569.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8J8XYP8, B3DMA1, F1LR43
      Related
      ENSRNOP00000059876.4, ENSRNOT00000068529.5
      Conserved Domains (2) summary
      pfam06741
      Location:262 → 324
      LsmAD; LsmAD domain
      pfam14438
      Location:120 → 188
      SM-ATX; Ataxin 2 SM domain

    2. NM_001415978.1 → NP_001402907.1  ataxin-2-like protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      Related
      ENSRNOP00000088482.1, ENSRNOT00000100664.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      190508878..190526263 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267772.1 → XP_063123842.1  ataxin-2-like protein isoform X21

    2. XM_063267774.1 → XP_063123844.1  ataxin-2-like protein isoform X22

    3. XM_039082960.2 → XP_038938888.1  ataxin-2-like protein isoform X14

      UniProtKB/TrEMBL
      A0A8J8XYP8
      Conserved Domains (5) summary
      PHA03247
      Location:588 → 1033
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:207 → 412
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK14971
      Location:413 → 559
      PRK14971; DNA polymerase III subunit gamma/tau
      pfam06741
      Location:262 → 324
      LsmAD; LsmAD domain
      pfam14438
      Location:121 → 194
      SM-ATX; Ataxin 2 SM domain

    4. XM_039082906.2 → XP_038938834.1  ataxin-2-like protein isoform X7

      UniProtKB/TrEMBL
      A0A0G2JYE0, A0A8I6AIZ1
      Conserved Domains (4) summary
      PHA03247
      Location:396 → 942
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:207 → 412
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      pfam06741
      Location:262 → 324
      LsmAD; LsmAD domain
      pfam14438
      Location:121 → 194
      SM-ATX; Ataxin 2 SM domain

    5. XM_039082925.2 → XP_038938853.1  ataxin-2-like protein isoform X10

      UniProtKB/TrEMBL
      A0A8J8XYP8
      Conserved Domains (4) summary
      PHA03247
      Location:588 → 1031
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:207 → 412
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      pfam06741
      Location:262 → 324
      LsmAD; LsmAD domain
      pfam14438
      Location:121 → 194
      SM-ATX; Ataxin 2 SM domain

    6. XM_006230303.4 → XP_006230365.1  ataxin-2-like protein isoform X3

      UniProtKB/TrEMBL
      A0A8I6AIZ1
      Related
      ENSRNOP00000070616.2, ENSRNOT00000080605.3
      Conserved Domains (3) summary
      pfam03153
      Location:758 → 939
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam06741
      Location:262 → 324
      LsmAD; LsmAD domain
      pfam14438
      Location:120 → 188
      SM-ATX; Ataxin 2 SM domain

    7. XM_039082940.2 → XP_038938868.1  ataxin-2-like protein isoform X12

      UniProtKB/TrEMBL
      A0A8J8XYP8
      Conserved Domains (5) summary
      PTZ00449
      Location:372 → 699
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03247
      Location:594 → 1039
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:207 → 412
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      pfam06741
      Location:262 → 324
      LsmAD; LsmAD domain
      pfam14438
      Location:121 → 194
      SM-ATX; Ataxin 2 SM domain

    8. XM_006230305.4 → XP_006230367.1  ataxin-2-like protein isoform X11

      UniProtKB/TrEMBL
      A0A8I6APD6, A0A8J8XYP8
      Related
      ENSRNOP00000096452.1, ENSRNOT00000100297.2
      Conserved Domains (3) summary
      pfam03153
      Location:764 → 945
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam06741
      Location:262 → 324
      LsmAD; LsmAD domain
      pfam14438
      Location:120 → 188
      SM-ATX; Ataxin 2 SM domain

    9. XM_039082899.2 → XP_038938827.1  ataxin-2-like protein isoform X5

      UniProtKB/TrEMBL
      A0A8I6AIZ1
      Conserved Domains (4) summary
      PHA03247
      Location:435 → 959
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:207 → 412
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      pfam06741
      Location:262 → 324
      LsmAD; LsmAD domain
      pfam14438
      Location:121 → 194
      SM-ATX; Ataxin 2 SM domain

    10. XM_039082915.2 → XP_038938843.1  ataxin-2-like protein isoform X9

      UniProtKB/TrEMBL
      A0A8J8XYP8
      Conserved Domains (5) summary
      PHA03247
      Location:435 → 946
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:207 → 412
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK07764
      Location:874 → 1059
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      pfam06741
      Location:262 → 324
      LsmAD; LsmAD domain
      pfam14438
      Location:121 → 194
      SM-ATX; Ataxin 2 SM domain

    11. XM_017589407.3 → XP_017444896.1  ataxin-2-like protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6AIZ1

    12. XM_063267769.1 → XP_063123839.1  ataxin-2-like protein isoform X20

    13. XM_063267765.1 → XP_063123835.1  ataxin-2-like protein isoform X17

    14. XM_063267763.1 → XP_063123833.1  ataxin-2-like protein isoform X16

    15. XM_039082968.2 → XP_038938896.1  ataxin-2-like protein isoform X18

      UniProtKB/TrEMBL
      A0A8I5ZWY9, A0A8J8XYP8
      Related
      ENSRNOP00000082404.1, ENSRNOT00000114675.2
      Conserved Domains (5) summary
      PHA03247
      Location:349 → 860
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:121 → 326
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      PRK07764
      Location:790 → 964
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      pfam06741
      Location:176 → 238
      LsmAD; LsmAD domain
      pfam14438
      Location:35 → 108
      SM-ATX; Ataxin 2 SM domain

    16. XM_063267767.1 → XP_063123837.1  ataxin-2-like protein isoform X19

    17. XM_063267760.1 → XP_063123830.1  ataxin-2-like protein isoform X15

    18. XM_063267740.1 → XP_063123810.1  ataxin-2-like protein isoform X8

    19. XM_063267753.1 → XP_063123823.1  ataxin-2-like protein isoform X13

    20. XM_063267731.1 → XP_063123801.1  ataxin-2-like protein isoform X6

    21. XM_039082898.2 → XP_038938826.1  ataxin-2-like protein isoform X4

      UniProtKB/TrEMBL
      A0A8I6AIZ1
      Related
      ENSRNOP00000099126.1, ENSRNOT00000137631.1
      Conserved Domains (4) summary
      PHA03247
      Location:584 → 1027
      PHA03247; large tegument protein UL36; Provisional
      COG5180
      Location:203 → 737
      PBP1; PAB1-binding protein PBP1, interacts with poly(A)-binding protein [RNA processing and modification]
      pfam06741
      Location:258 → 320
      LsmAD; LsmAD domain
      pfam14438
      Location:117 → 190
      SM-ATX; Ataxin 2 SM domain

    22. XM_063267719.1 → XP_063123789.1  ataxin-2-like protein isoform X2

    23. XM_063267713.1 → XP_063123783.1  ataxin-2-like protein isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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