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    Zfp710 zinc finger protein 710 [ Mus musculus (house mouse) ]

    Gene ID: 209225, updated on 16-Dec-2024

    Summary

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    Official Symbol
    Zfp710provided by MGI
    Official Full Name
    zinc finger protein 710provided by MGI
    Primary source
    MGI:MGI:1921747
    See related
    Ensembl:ENSMUSG00000048897 AllianceGenome:MGI:1921747
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf710; 9830165K13; 5430400N05Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in early conceptus; embryo ectoderm; eye; and oocyte. Orthologous to human ZNF710 (zinc finger protein 710). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 18.4), lung adult (RPKM 17.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp710 in Genome Data Viewer
    Location:
    7 D2; 7 45.36 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (79674581..79742498)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80024814..80092751)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 5430400D12 gene Neighboring gene actin-related protein 2/3 complex inhibitor Neighboring gene predicted gene, 31966 Neighboring gene STARR-seq mESC enhancer starr_19293 Neighboring gene STARR-seq mESC enhancer starr_19295 Neighboring gene STARR-seq mESC enhancer starr_19296 Neighboring gene STARR-positive B cell enhancer ABC_E4939 Neighboring gene STARR-positive B cell enhancer ABC_E8970 Neighboring gene STARR-seq mESC enhancer starr_19297 Neighboring gene STARR-positive B cell enhancer ABC_E6561 Neighboring gene STARR-positive B cell enhancer ABC_E6562 Neighboring gene STARR-positive B cell enhancer ABC_E6563 Neighboring gene predicted gene, 21057 Neighboring gene isocitrate dehydrogenase 2 (NADP+), mitochondrial Neighboring gene STARR-seq mESC enhancer starr_19312 Neighboring gene predicted gene, 53380 Neighboring gene STARR-positive B cell enhancer ABC_E3729 Neighboring gene STARR-positive B cell enhancer ABC_E6564 Neighboring gene predicted gene 45202

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 710

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145999.2 → NP_001139471.1  zinc finger protein 710 isoform a

      See identical proteins and their annotated locations for NP_001139471.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AC110903, AC164075
      Consensus CDS
      CCDS52280.1
      UniProtKB/Swiss-Prot
      Q3U288, Q3U341, Q3U396, Q6P9R3, Q8BJH0, Q8BTL6, Q8BZ48
      Related
      ENSMUSP00000132361.3, ENSMUST00000164056.9
      Conserved Domains (4) summary
      COG5048
      Location:418 → 595
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:299 → 319
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:325 → 347
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:339 → 364
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001146000.2 → NP_001139472.1  zinc finger protein 710 isoform b

      See identical proteins and their annotated locations for NP_001139472.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and includes an alternate exon that causes a frameshift in the 3' coding region, compared to variant 1. The resulting isoform (b) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AC110903, AC164075
      Consensus CDS
      CCDS52279.1
      UniProtKB/Swiss-Prot
      Q3U288
      Related
      ENSMUSP00000129357.2, ENSMUST00000166250.8
      Conserved Domains (2) summary
      COG5048
      Location:337 → 595
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:299 → 319
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_175433.6 → NP_780642.3  zinc finger protein 710 isoform a

      See identical proteins and their annotated locations for NP_780642.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AC110903, AC164075
      Consensus CDS
      CCDS52280.1
      UniProtKB/Swiss-Prot
      Q3U288, Q3U341, Q3U396, Q6P9R3, Q8BJH0, Q8BTL6, Q8BZ48
      Related
      ENSMUSP00000050577.9, ENSMUST00000049680.10
      Conserved Domains (4) summary
      COG5048
      Location:418 → 595
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:299 → 319
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:325 → 347
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:339 → 364
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      79674581..79742498
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242314.2 → XP_030098174.1  zinc finger protein 710 isoform X2

      Conserved Domains (2) summary
      COG5048
      Location:337 → 595
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:299 → 319
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_006540744.5 → XP_006540807.1  zinc finger protein 710 isoform X1

      See identical proteins and their annotated locations for XP_006540807.1

      UniProtKB/Swiss-Prot
      Q3U288, Q3U341, Q3U396, Q6P9R3, Q8BJH0, Q8BTL6, Q8BZ48
      Conserved Domains (4) summary
      COG5048
      Location:418 → 595
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:299 → 319
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:325 → 347
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:339 → 364
      zf-H2C2_2; Zinc-finger double domain

    3. XM_006540742.5 → XP_006540805.1  zinc finger protein 710 isoform X1

      See identical proteins and their annotated locations for XP_006540805.1

      UniProtKB/Swiss-Prot
      Q3U288, Q3U341, Q3U396, Q6P9R3, Q8BJH0, Q8BTL6, Q8BZ48
      Conserved Domains (4) summary
      COG5048
      Location:418 → 595
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:299 → 319
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:325 → 347
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:339 → 364
      zf-H2C2_2; Zinc-finger double domain

    4. XM_006540743.5 → XP_006540806.1  zinc finger protein 710 isoform X1

      See identical proteins and their annotated locations for XP_006540806.1

      UniProtKB/Swiss-Prot
      Q3U288, Q3U341, Q3U396, Q6P9R3, Q8BJH0, Q8BTL6, Q8BZ48
      Conserved Domains (4) summary
      COG5048
      Location:418 → 595
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:299 → 319
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:325 → 347
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:339 → 364
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U288.1 GenPept UniProtKB/Swiss-Prot:Q3U288

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