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    sca-1 Calcium-transporting ATPase [ Caenorhabditis elegans ]

    Gene ID: 176512, updated on 9-Dec-2024

    Summary

    Official Symbol
    sca-1
    Official Full Name
    Calcium-transporting ATPase
    Primary source
    WormBase:WBGene00004736
    Locus tag
    CELE_K11D9.2
    See related
    AllianceGenome:WB:WBGene00004736
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables P-type calcium transporter activity and chromatin DNA binding activity. Involved in several processes, including IRE1-mediated unfolded protein response; determination of adult lifespan; and multicellular organismal-level water homeostasis. Located in several cellular components, including nuclear envelope; nuclear outer membrane-endoplasmic reticulum membrane network; and sarcoplasmic reticulum. Is expressed in several structures, including egg-laying apparatus; excretory system; intestine; non-striated muscle; and spermatheca. Human ortholog(s) of this gene implicated in Brody myopathy; acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Orthologous to several human genes including ATP2A3 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See sca-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (10811906..10816844, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Kinesin-like protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables P-type calcium transporter activity  
    enables P-type calcium transporter activity PubMed 
    enables P-type calcium transporter activity  
    enables chromatin DNA binding PubMed 
    enables nucleotide binding  
    enables transporter activity  
    Process Evidence Code Pubs
    involved_in IRE1-mediated unfolded protein response PubMed 
    involved_in IRE1-mediated unfolded protein response PubMed 
    involved_in calcium ion import PubMed 
    involved_in calcium ion transmembrane transport  
    involved_in calcium ion transport  
    involved_in dauer larval development PubMed 
    involved_in defense response to Gram-negative bacterium PubMed 
    involved_in determination of adult lifespan PubMed 
    involved_in embryo development ending in birth or egg hatching PubMed 
    involved_in endoplasmic reticulum unfolded protein response PubMed 
    involved_in intracellular calcium ion homeostasis  
    involved_in intracellular calcium ion homeostasis PubMed 
    involved_in multicellular organismal-level water homeostasis PubMed 
    involved_in negative regulation of gene expression PubMed 
    involved_in nematode larval development PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle PubMed 
    located_in endoplasmic reticulum PubMed 
    is_active_in membrane  
    located_in membrane  
    located_in nuclear envelope PubMed 
    located_in nuclear outer membrane-endoplasmic reticulum membrane network PubMed 
    located_in sarcoplasmic reticulum PubMed 
    located_in sarcoplasmic reticulum  
    located_in sarcoplasmic reticulum membrane  

    General protein information

    Preferred Names
    Calcium-transporting ATPase
    NP_001122708.1
    • Partially confirmed by transcript evidence
    NP_499385.3
    • Confirmed by transcript evidence
    NP_499386.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10811906..10816844 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066984.9 → NP_499385.3  Calcium-transporting ATPase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499385.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XU13
      Conserved Domains (6) summary
      TIGR01116
      Location:52 → 990
      ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
      pfam00122
      Location:95 → 342
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:785 → 988
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:4 → 71
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12710
      Location:607 → 713
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:423 → 529
      Cation_ATPase; Cation transport ATPase (P-type)
    2. NM_066985.7 → NP_499386.1  Calcium-transporting ATPase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499386.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEK8
      Conserved Domains (6) summary
      TIGR01116
      Location:52 → 990
      ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
      pfam00122
      Location:95 → 342
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:785 → 988
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:4 → 71
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12710
      Location:607 → 713
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:423 → 529
      Cation_ATPase; Cation transport ATPase (P-type)
    3. NM_001129236.4 → NP_001122708.1  Calcium-transporting ATPase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122708.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8WI68
      Conserved Domains (5) summary
      TIGR01116
      Location:1 → 863
      ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
      pfam00122
      Location:2 → 215
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:658 → 861
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam12710
      Location:480 → 586
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:296 → 402
      Cation_ATPase; Cation transport ATPase (P-type)
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