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    Y55D5A.3 N-acylethanolamine-hydrolyzing acid amidase subunit beta [ Caenorhabditis elegans ]

    Gene ID: 190304, updated on 9-Dec-2024

    Summary

    Official Symbol
    Y55D5A.3
    Official Full Name
    N-acylethanolamine-hydrolyzing acid amidase subunit beta
    Primary source
    WormBase:WBGene00021917
    Locus tag
    CELE_Y55D5A.3
    See related
    AllianceGenome:WB:WBGene00021917
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable fatty acid amide hydrolase activity. Predicted to be involved in N-acylethanolamine metabolic process and fatty acid metabolic process. Predicted to be located in lysosome and membrane. Orthologous to human NAAA (N-acylethanolamine acid amidase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See Y55D5A.3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (2970251..2975789, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene SPK domain-containing protein Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene Mediator complex subunit 8 Neighboring gene MATH domain-containing protein Neighboring gene Insulin-like receptor subunit beta;Protein kinase domain-containing protein;receptor protein-tyrosine kinase Neighboring gene ncRNA

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables N-(long-chain-acyl)ethanolamine deacylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables fatty acid amide hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables fatty acid amide hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in N-acylethanolamine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fatty acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    N-acylethanolamine-hydrolyzing acid amidase subunit beta
    NP_497647.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      2970251..2975789 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065246.2NP_497647.1  N-acylethanolamine-hydrolyzing acid amidase subunit beta [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497647.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9GUI1
      Conserved Domains (2) summary
      cd01903
      Location:104341
      Ntn_AC_NAAA; AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and ...
      pfam15508
      Location:2178
      NAAA-beta; beta subunit of N-acylethanolamine-hydrolyzing acid amidase