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    twk-2 Potassium channel domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 188452, updated on 9-Dec-2024

    Summary

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    Official Symbol
    twk-2
    Official Full Name
    Potassium channel domain-containing protein
    Primary source
    WormBase:WBGene00006657
    Locus tag
    CELE_T12C9.3
    See related
    AllianceGenome:WB:WBGene00006657
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See twk-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    25
    Sequence:
    Chromosome: II; NC_003280.10 (4441103..4453151, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Nuclear Hormone Receptor family Neighboring gene Nuclear hormone receptor family member nhr-16 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene CYCLIN domain-containing protein;Cyclin-like domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High-fidelity encoding of mechanostimuli by tactile food-sensing neurons requires an ensemble of ion channels. Fok A, et al. Cell Rep, 2023 May 30. PMID 37119137, Free PMC Article
    2. Differential modulation of C. elegans motor behavior by NALCN and two-pore domain potassium channels. Zhou C, et al. PLoS Genet, 2022 Apr. PMID 35482723, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables outward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium ion leak channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Potassium channel domain-containing protein
    NP_001350984.1
    • Partially confirmed by transcript evidence
    NP_001350985.1
    • Partially confirmed by transcript evidence
    NP_001350986.1
    • Partially confirmed by transcript evidence
    NP_001350987.1
    • Partially confirmed by transcript evidence
    NP_001350988.1
    • Partially confirmed by transcript evidence
    NP_494786.5
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      4441103..4453151 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001364063.2 → NP_001350984.1  Potassium channel domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2X0RDZ3
      Conserved Domains (1) summary
      pfam07885
      Location:285 → 360
      Ion_trans_2; Ion channel

    2. NM_001364060.1 → NP_001350986.1  Potassium channel domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2X0RCW6
      Conserved Domains (1) summary
      pfam07885
      Location:285 → 360
      Ion_trans_2; Ion channel

    3. NM_001364061.1 → NP_001350985.1  Potassium channel domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2X0REL6
      Conserved Domains (1) summary
      pfam07885
      Location:285 → 360
      Ion_trans_2; Ion channel

    4. NM_001364062.1 → NP_001350987.1  Potassium channel domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2X0REA8
      Conserved Domains (1) summary
      pfam07885
      Location:285 → 360
      Ion_trans_2; Ion channel

    5. NM_001364064.3 → NP_001350988.1  Potassium channel domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2X0SX30
      Conserved Domains (1) summary
      pfam07885
      Location:285 → 360
      Ion_trans_2; Ion channel

    6. NM_062385.7 → NP_494786.5  Potassium channel domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2X0RQ43
      Conserved Domains (1) summary
      pfam07885
      Location:285 → 360
      Ion_trans_2; Ion channel
    Nucleotide Protein
    Heading Accession and Version

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