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    PCL10 Pcl10p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852743, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PCL10
    Official Full Name
    Pcl10p
    Primary source
    SGD:S000003102
    Locus tag
    YGL134W
    See related
    AllianceGenome:SGD:S000003102; FungiDB:YGL134W; VEuPathDB:YGL134W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in negative regulation of glycogen biosynthetic process. Part of cyclin-dependent protein kinase holoenzyme complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PCL10 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (255663..256964)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene 21S rRNA (uridine2791-2'-O) methyltransferase Neighboring gene ribosomal 60S subunit protein L1B Neighboring gene Itc1p Neighboring gene DNA-binding E3 ubiquitin-protein ligase SNT2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New structural insights into phosphorylation-free mechanism for full cyclin-dependent kinase (CDK)-cyclin activity and substrate recognition. Zheng F, et al. J Biol Chem, 2013 Oct 18. PMID 24022486, Free PMC Article
    2. Disruption of six novel ORFs from Saccharomyces cerevisiae chromosome VII and phenotypic analysis of the deletants. Victoria Escribano M, et al. Yeast, 2000 May. PMID 10806424
    3. Substrate targeting of the yeast cyclin-dependent kinase Pho85p by the cyclin Pcl10p. Wilson WA, et al. Mol Cell Biol, 1999 Oct. PMID 10490639, Free PMC Article
    4. Analysis of respiratory mutants reveals new aspects of the control of glycogen accumulation by the cyclin-dependent protein kinase Pho85p. Wilson WA, et al. FEBS Lett, 2002 Mar 27. PMID 11943203
    5. Pho85 phosphorylates the Glc7 protein phosphatase regulator Glc8 in vivo. Tan YS, et al. J Biol Chem, 2003 Jan 3. PMID 12407105

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycogen metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of glycogen biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of glycogen biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cyclin-dependent protein kinase holoenzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cyclin-dependent protein kinase holoenzyme complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Pcl10p
    NP_011381.1
    • Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate; PCL10 has a paralog, PCL8, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      255663..256964
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180999.1 → NP_011381.1  TPA: Pcl10p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011381.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU15, P53124
      UniProtKB/TrEMBL
      B3LHJ2, B5VIJ7, C7GX67, N1P2Z4
      Conserved Domains (1) summary
      cd20558
      Location:306 → 412
      CYCLIN_ScPCL7-like; cyclin box found in Saccharomyces cerevisiae PHO85 cyclin-7 (ScPCL7) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53124.1

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