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    Roc1a Regulator of cullins 1a [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31014, updated on 9-Dec-2024

    Summary

    Official Symbol
    Roc1aprovided by FlyBase
    Official Full Name
    Regulator of cullins 1aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025638
    Locus tag
    Dmel_CG16982
    See related
    AllianceGenome:FB:FBgn0025638
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey65; BEST:CK01110; CG16982; CK01110; Dmel\CG16982; dRbx1; dRoc1; dRoc1a; EG:115C2.11; Rbx1; Rbx1/Roc; Roc; Roc1; ROC1; roc1a; Roc1alpha
    Summary
    Enables cullin family protein binding activity and ubiquitin protein ligase activity. Involved in several processes, including negative regulation of signal transduction; positive regulation of neuron remodeling; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in nucleus. Part of cullin-RING ubiquitin ligase complex. Is expressed in organism and wing disc. Orthologous to human RBX1 (ring-box 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Roc1a in Genome Data Viewer
    Location:
    1B13-1B13; 1-0 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (647304..648597)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (541337..542630)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene Histone methyltransferase 4-20 Neighboring gene SKP1-related A Neighboring gene pseudo

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables NEDD8 ligase activity  
    enables cullin family protein binding  
    enables cullin family protein binding PubMed 
    enables protein binding PubMed 
    enables ubiquitin protein ligase activity  
    enables ubiquitin protein ligase activity PubMed 
    enables ubiquitin-protein transferase activity PubMed 
    enables zinc ion binding  
    enables zinc ion binding PubMed 
    enables zinc ion binding PubMed 
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex PubMed 
    part_of Cul2-RING ubiquitin ligase complex PubMed 
    part_of Cul3-RING ubiquitin ligase complex PubMed 
    part_of Cul4-RING E3 ubiquitin ligase complex PubMed 
    part_of SCF ubiquitin ligase complex PubMed 
    part_of SCF ubiquitin ligase complex PubMed 
    part_of cullin-RING ubiquitin ligase complex  
    is_active_in nucleus  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    regulator of cullins 1a
    Names
    CG16982-PA
    CG16982-PC
    CG16982-PD
    Roc1a-PA
    Roc1a-PC
    Roc1a-PD
    SCF-betaTrCP complex

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      647304..648597
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144671.3 → NP_001138143.2  regulator of cullins 1a, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138143.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z114
      Conserved Domains (2) summary
      COG5194
      Location:53 → 136
      APC11; Component of SCF ubiquitin ligase and anaphase-promoting complex [Posttranslational modification, protein turnover, chaperones / Cell division and chromosome partitioning]
      pfam12678
      Location:53 → 126
      zf-rbx1; RING-H2 zinc finger
    2. NM_001297825.1 → NP_001284754.1  regulator of cullins 1a, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284754.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77429, Q9W5E1
      UniProtKB/TrEMBL
      X2JA05
      Conserved Domains (1) summary
      cd16485
      Location:40 → 101
      mRING-H2-C3H2C2D_RBX1; modified RING finger, H2 subclass (C3H2C2D-type), found in RING-box protein 1 (RBX1) and similar proteins
    3. NM_130496.4 → NP_569852.1  regulator of cullins 1a, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569852.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77429, Q9W5E1
      UniProtKB/TrEMBL
      X2JA05
      Related
      FBpp0070117
      Conserved Domains (1) summary
      cd16485
      Location:40 → 101
      mRING-H2-C3H2C2D_RBX1; modified RING finger, H2 subclass (C3H2C2D-type), found in RING-box protein 1 (RBX1) and similar proteins
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