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    bt bent [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43814, updated on 17-Dec-2024

    Summary

    Official Symbol
    btprovided by FlyBase
    Official Full Name
    bentprovided by FlyBase
    Primary source
    FLYBASE:FBgn0005666
    Locus tag
    Dmel_CG32019
    See related
    AllianceGenome:FB:FBgn0005666
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    39c-18; Bt; CG10285; CG1479; CG32019; CT3598; CT8086; Dmel\CG32019; l(2)2; l(2)23; l(4)102CDa; l(4)2; l(4)21; l(4)23; l(4)37; l(4)38; l(4)PT-2; Prj; projectin; titin
    Summary
    Enables protein kinase activity. A structural constituent of muscle. Involved in mesoderm development; muscle thin filament assembly; and sarcomere organization. Located in Z disc. Is expressed in several structures, including adult head; adult heart; border follicle cell; muscle cell; and muscle system. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple) and myopathy (multiple). Orthologous to several human genes including TTN (titin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    Location:
    102D5-102E1; 4-0 cM
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (724400..776474)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (745026..797100)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene myoglianin Neighboring gene eyeless Neighboring gene long non-coding RNA:CR45200 Neighboring gene Mediator complex subunit 26

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    mobile_element

    • Loc: 729819-730256 mobile_element_type = transposon:INE-1{}1980
    • Loc: 749321-749642 mobile_element_type = transposon:INE-1{}2051
    • Loc: 749972-750190 mobile_element_type = transposon:INE-1{}2053
    • Loc: 751516-751635 mobile_element_type = transposon:INE-1{}2073
    • Loc: 757191-757463 mobile_element_type = transposon:INE-1{}2074
    • Loc: 773208-773805 mobile_element_type = transposon:Tc1{}1529

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding  
    enables protein kinase activity PubMed 
    enables protein kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables structural constituent of muscle PubMed 
    Process Evidence Code Pubs
    involved_in mesoderm development PubMed 
    involved_in muscle thin filament assembly PubMed 
    involved_in protein phosphorylation  
    involved_in sarcomere organization  
    involved_in sarcomere organization PubMed 
    Component Evidence Code Pubs
    located_in I band PubMed 
    is_active_in M band  
    located_in Z disc PubMed 
    located_in sarcomere PubMed 

    General protein information

    Preferred Names
    bent
    Names
    C-protein
    CG32019-PC
    CG32019-PF
    CG32019-PH
    CG32019-PI
    CG32019-PJ
    bt-PC
    bt-PF
    bt-PH
    bt-PI
    bt-PJ
    lethal(4) Powell, Tennessee-2
    myosin LCK
    projectin
    projectin myosin light chain kinase
    twitchin
    NP_001162825.1
    NP_001259071.1
    NP_001259072.1
    NP_001284716.1
    NP_995598.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      724400..776474
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272143.2 → NP_001259072.1  bent, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259072.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L0MN91
      Conserved Domains (10) summary
      cd00096
      Location:7205 → 7272
      Ig; Immunoglobulin domain
      cd05748
      Location:6115 → 6188
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
      smart00408
      Location:8579 → 8644
      IGc2; Immunoglobulin C-2 Type
      smart00220
      Location:7922 → 8177
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00409
      Location:4922 → 5002
      IG; Immunoglobulin
      smart00410
      Location:1436 → 1521
      IG_like; Immunoglobulin like
      cd00063
      Location:6292 → 6384
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:8565 → 8654
      I-set; Immunoglobulin I-set domain
      cd14114
      Location:7919 → 8177
      STKc_Twitchin_like; The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin
      cl11960
      Location:3449 → 3523
      Ig; Immunoglobulin domain
    2. NM_001169354.2 → NP_001162825.1  bent, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162825.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1YSG0
      Conserved Domains (10) summary
      cd00096
      Location:7272 → 7339
      Ig; Immunoglobulin domain
      cd05748
      Location:6182 → 6255
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
      smart00408
      Location:8646 → 8711
      IGc2; Immunoglobulin C-2 Type
      smart00220
      Location:7989 → 8244
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00409
      Location:4989 → 5069
      IG; Immunoglobulin
      smart00410
      Location:1503 → 1588
      IG_like; Immunoglobulin like
      cd00063
      Location:6359 → 6451
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:8632 → 8721
      I-set; Immunoglobulin I-set domain
      cd14114
      Location:7986 → 8244
      STKc_Twitchin_like; The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin
      cl11960
      Location:3516 → 3590
      Ig; Immunoglobulin domain
    3. NM_205876.3 → NP_995598.1  bent, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995598.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KQP6
      Conserved Domains (10) summary
      cd00096
      Location:6987 → 7054
      Ig; Immunoglobulin domain
      cd05748
      Location:5897 → 5970
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
      smart00408
      Location:8361 → 8426
      IGc2; Immunoglobulin C-2 Type
      smart00220
      Location:7704 → 7959
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00409
      Location:4704 → 4784
      IG; Immunoglobulin
      smart00410
      Location:7069 → 7155
      IG_like; Immunoglobulin like
      cd00063
      Location:6074 → 6166
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:8347 → 8436
      I-set; Immunoglobulin I-set domain
      cd14114
      Location:7701 → 7959
      STKc_Twitchin_like; The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin
      cl11960
      Location:3231 → 3305
      Ig; Immunoglobulin domain
    4. NM_001297787.1 → NP_001284716.1  bent, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284716.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JD89
      Conserved Domains (10) summary
      cd00096
      Location:6941 → 7008
      Ig; Immunoglobulin domain
      cd05748
      Location:5851 → 5924
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
      smart00408
      Location:8315 → 8380
      IGc2; Immunoglobulin C-2 Type
      smart00220
      Location:7658 → 7913
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00409
      Location:4658 → 4738
      IG; Immunoglobulin
      smart00410
      Location:7023 → 7109
      IG_like; Immunoglobulin like
      cd00063
      Location:6028 → 6120
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:8301 → 8390
      I-set; Immunoglobulin I-set domain
      cd14114
      Location:7655 → 7913
      STKc_Twitchin_like; The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin
      cl11960
      Location:3185 → 3259
      Ig; Immunoglobulin domain
    5. NM_001272142.1 → NP_001259071.1  bent, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259071.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L0MPZ1
      Conserved Domains (10) summary
      cd00096
      Location:6766 → 6833
      Ig; Immunoglobulin domain
      cd05748
      Location:5676 → 5749
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
      smart00408
      Location:8121 → 8186
      IGc2; Immunoglobulin C-2 Type
      smart00220
      Location:7483 → 7738
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00409
      Location:4483 → 4563
      IG; Immunoglobulin
      smart00410
      Location:6848 → 6934
      IG_like; Immunoglobulin like
      cd00063
      Location:5853 → 5945
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:8107 → 8196
      I-set; Immunoglobulin I-set domain
      cd14114
      Location:7480 → 7738
      STKc_Twitchin_like; The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin
      cl11960
      Location:3010 → 3084
      Ig; Immunoglobulin domain
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