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    Adss Adenylosuccinate synthetase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42466, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adssprovided by FlyBase
    Official Full Name
    Adenylosuccinate synthetaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027493
    Locus tag
    Dmel_CG17273
    See related
    AllianceGenome:FB:FBgn0027493
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AdSS; BcDNA:LD32788; CG17273; Dmel\CG17273; PURA_DROME
    Summary
    Predicted to enable adenylosuccinate synthase activity. Predicted to be involved in 'de novo' AMP biosynthetic process and IMP metabolic process. Predicted to be active in cytoplasm. Is expressed in adult head. Orthologous to several human genes including ADSS2 (adenylosuccinate synthase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Adss in Genome Data Viewer
    Location:
    93A1-93A1; 3-69 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20824667..20830580, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16650389..16656302, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ribosomal protein S20 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44047 Neighboring gene uncharacterized protein Neighboring gene Syndapin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Adenosine nucleotide biosynthesis and AMPK regulate adult life span and mediate the longevity benefit of caloric restriction in flies. Stenesen D, et al. Cell Metab, 2013 Jan 8. PMID 23312286, Free PMC Article
    2. Chromosomal instability causes sensitivity to protein folding stress and ATP depletion. Khan M, et al. Biol Open, 2018 Oct 16. PMID 30327366, Free PMC Article
    3. Phylogeny and evolution of mycophagy in the Zygothrica genus group (Diptera: Drosophilidae). Zhang Y, et al. Mol Phylogenet Evol, 2021 Oct. PMID 34252547
    4. PINK1 and Parkin regulate IP(3)R-mediated ER calcium release. Ham SJ, et al. Nat Commun, 2023 Aug 25. PMID 37626046, Free PMC Article
    5. A protein trap strategy to detect GFP-tagged proteins expressed from their endogenous loci in Drosophila. Morin X, et al. Proc Natl Acad Sci U S A, 2001 Dec 18. PMID 11742088, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylosuccinate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylosuccinate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' AMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in IMP metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in purine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    adenylosuccinate synthetase
    Names
    Adss-PA
    CG17273-PA
    NP_650918.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20824667..20830580 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142661.3 → NP_650918.1  adenylosuccinate synthetase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650918.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MZ11, Q9VDI2, Q9Y0Y2
      Related
      FBpp0083395
      Conserved Domains (1) summary
      pfam00709
      Location:28 → 444
      Adenylsucc_synt; Adenylosuccinate synthetase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y0Y2.1 Q9Y0Y2

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