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    F13b coagulation factor XIII, beta subunit [ Mus musculus (house mouse) ]

    Gene ID: 14060, updated on 27-Nov-2024

    Summary

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    Official Symbol
    F13bprovided by MGI
    Official Full Name
    coagulation factor XIII, beta subunitprovided by MGI
    Primary source
    MGI:MGI:88379
    See related
    Ensembl:ENSMUSG00000026368 AllianceGenome:MGI:88379
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cf13b; Cf-13b
    Summary
    This gene encodes subunit B of the coagulation factor XIII that catalyzes the final step of the blood coagulation pathway. The encoded protein associates with subunit A to form a heterotetrameric protein that circulates in the plasma. During the blood coagulation process, thrombin-mediated proteolytic cleavage of the subunit A results in the dissociation of the encoded protein from the heterotetramer. Male mice lacking the encoded protein exhibit mild fibrosis together with hemosiderin deposits in the heart. [provided by RefSeq, Sep 2015]
    Expression
    Biased expression in liver E18 (RPKM 52.8), liver adult (RPKM 17.8) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See F13b in Genome Data Viewer
    Location:
    1 F; 1 61.57 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (139429285..139451496)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (139501547..139523758)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5812 Neighboring gene zinc finger and BTB domain containing 41 Neighboring gene STARR-seq mESC enhancer starr_02479 Neighboring gene abnormal spindle microtubule assembly Neighboring gene STARR-seq mESC enhancer starr_02480 Neighboring gene STARR-seq mESC enhancer starr_02481 Neighboring gene complement factor H-related 1 Neighboring gene complement factor H-related 3 Neighboring gene STARR-seq mESC enhancer starr_02482 Neighboring gene STARR-seq mESC enhancer starr_02483 Neighboring gene STARR-seq mESC enhancer starr_02484

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Male-specific cardiac pathologies in mice lacking either the A or B subunit of factor XIII. Souri M, et al. Thromb Haemost, 2008 Feb. PMID 18278192
    2. Sustained depletion of FXIII-A by inducing acquired FXIII-B deficiency. Strilchuk AW, et al. Blood, 2020 Dec 17. PMID 32678423, Free PMC Article
    3. Transglutaminase 2 and Factor XIII catalyze distinct substrates in differentiating osteoblastic cell line: utility of highly reactive substrate peptides. Watanabe K, et al. Amino Acids, 2013 Jan. PMID 22045386
    4. Molecular cloning of the b subunit of mouse coagulation factor XIII and assignment of the gene to chromosome 1: close evolutionary relationship to complement factor H. Nonaka M, et al. Genomics, 1993 Mar. PMID 8468048
    5. Reciprocal stabilization of coagulation factor XIII-A and -B subunits is a determinant of plasma FXIII concentration. Byrnes JR, et al. Blood, 2024 Feb 1. PMID 37883802,

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Reciprocal stabilization of coagulation factor XIII-A and -B subunits is a determinant of plasma FXIII concentration.
      Title: Reciprocal stabilization of coagulation factor XIII-A and -B subunits is a determinant of plasma FXIII concentration.
    2. Sustained depletion of FXIII-A by inducing acquired FXIII-B deficiency.
      Title: Sustained depletion of FXIII-A by inducing acquired FXIII-B deficiency.
    3. These findings provide insight into assembly of the fibrinogen/FXIII-A2B2 complex in both physiologic and therapeutic situations.
      Title: The interaction between fibrinogen and zymogen FXIII-A2B2 is mediated by fibrinogen residues γ390-396 and the FXIII-B subunits.
    4. Physiological significance of mouse TG2 and Factor XIII through identification of substrate proteins in MC3T3-E1 cells.
      Title: Transglutaminase 2 and Factor XIII catalyze distinct substrates in differentiating osteoblastic cell line: utility of highly reactive substrate peptides.
    5. Carditis and fibrosis in FXIII-deficient mice might be caused by a faulty or delayed reparative process that was initiated by abnormal haemorrhagic events within heart tissue.
      Title: Male-specific cardiac pathologies in mice lacking either the A or B subunit of factor XIII.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in blood coagulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in blood coagulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in blood coagulation, fibrin clot formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in blood coagulation, fibrin clot formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    coagulation factor XIII B chain
    Names
    protein-glutamine gamma-glutamyltransferase B chain
    transglutaminase B chain
    NP_112441.2
    XP_006529195.1
    XP_006529196.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031164.2 → NP_112441.2  coagulation factor XIII B chain precursor

      See identical proteins and their annotated locations for NP_112441.2

      Status: REVIEWED

      Source sequence(s)
      AI115049, AI527143, AK149397, AW213546, BB718926
      Consensus CDS
      CCDS48386.1
      UniProtKB/Swiss-Prot
      B1AY02, Q07968
      UniProtKB/TrEMBL
      Q3UER0
      Related
      ENSMUSP00000027615.6, ENSMUST00000027615.7
      Conserved Domains (3) summary
      cd00033
      Location:275 → 329
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:214 → 268
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:275 → 580
      PHA02927; secreted complement-binding protein; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      139429285..139451496
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529133.3 → XP_006529196.1  coagulation factor XIII B chain isoform X2

      UniProtKB/TrEMBL
      Q3UER0
      Conserved Domains (2) summary
      cd00033
      Location:463 → 517
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      PHA02927
      Location:103 → 390
      PHA02927; secreted complement-binding protein; Provisional

    2. XM_006529132.5 → XP_006529195.1  coagulation factor XIII B chain isoform X1

      UniProtKB/TrEMBL
      Q3UER0
      Conserved Domains (2) summary
      cd00033
      Location:226 → 280
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      PHA02927
      Location:116 → 403
      PHA02927; secreted complement-binding protein; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07968.2 GenPept UniProtKB/Swiss-Prot:Q07968

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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