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    Slc24a2 solute carrier family 24 member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84550, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc24a2provided by RGD
    Official Full Name
    solute carrier family 24 member 2provided by RGD
    Primary source
    RGD:628650
    See related
    EnsemblRapid:ENSRNOG00000008169 AllianceGenome:RGD:628650
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nckx2
    Summary
    Enables calcium, potassium:sodium antiporter activity. Involved in calcium ion transmembrane transport and protein-containing complex assembly. Predicted to be located in membrane. Predicted to be active in plasma membrane; postsynapse; and presynapse. Orthologous to human SLC24A2 (solute carrier family 24 member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 315.0) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc24a2 in Genome Data Viewer
    Location:
    5q32
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (106543867..106787810, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (101497916..101741840, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (105336287..105579959, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486948 Neighboring gene small ribosomal subunit protein uS10-like Neighboring gene alkaline ceramidase 2 Neighboring gene uncharacterized LOC134486949 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene uncharacterized LOC108350995

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Different cation sensitivities and binding site domains of Na+-Ca2+-K+ and Na+-Ca2+ exchangers. Uehara A, et al. J Cell Physiol, 2005 May. PMID 15534861
    2. Topological studies of the rat brain K+-dependent Na+/Ca2+ exchanger NCKX2. Cai X, et al. Ann N Y Acad Sci, 2002 Nov. PMID 12502542
    3. A critical role for miR‑135a‑5p‑mediated regulation of SLC24A2 in neuropathic pain. Zhou XG, et al. Mol Med Rep, 2020 Sep. PMID 32582988
    4. Electrophysiological characterization and ionic stoichiometry of the rat brain K(+)-dependent NA(+)/CA(2+) exchanger, NCKX2. Dong H, et al. J Biol Chem, 2001 Jul 13. PMID 11342562
    5. Na+/Ca2+-K+ exchangers (NCKX): functional properties and physiological roles. Altimimi HF, et al. Channels (Austin), 2007 Mar-Apr. PMID 18690016

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A critical role for miR135a5pmediated regulation of SLC24A2 in neuropathic pain.
      Title: A critical role for miR‑135a‑5p‑mediated regulation of SLC24A2 in neuropathic pain.
    2. Preferential expression of plasmalemmal K-dependent Na+/Ca2+ exchangers in neurons versus astrocytes.
      Title: Preferential expression of plasmalemmal K-dependent Na+/Ca2+ exchangers in neurons versus astrocytes.
    3. PKC-mediated activation of NCKX2 is sensitive to mutation of multiple PKC consensus sites via a mechanism that may involve several phosphorylation events
      Title: Protein kinase C-dependent enhancement of activity of rat brain NCKX2 heterologously expressed in HEK293 cells.
    4. topological studies of this protein in rat brain
      Title: Topological studies of the rat brain K+-dependent Na+/Ca2+ exchanger NCKX2.
    5. association as a dimer, an interaction that does not require, but may be stabilized by, a disulfide linkage through Cys-395
      Title: A novel topology and redox regulation of the rat brain K+-dependent Na+/Ca2+ exchanger, NCKX2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium, potassium:sodium antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium, potassium:sodium antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium, potassium:sodium antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium, potassium:sodium antiporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables calcium, potassium:sodium antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion import ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in calcium ion import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of localization in cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within establishment of localization in cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in learning IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within learning ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-term synaptic depression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-term synaptic depression IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within long-term synaptic depression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-term synaptic potentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-term synaptic potentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in memory IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within memory ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron cellular homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neuron cellular homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sodium/potassium/calcium exchanger 2
    Names
    Na(+)/K(+)/Ca(2+)-exchange protein 2
    potassium-dependent sodium-calcium exchanger
    retinal cone Na-Ca+K exchanger
    solute carrier family 24 (sodium/potassium/calcium exchanger), member 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031743.4 → NP_113931.1  sodium/potassium/calcium exchanger 2

      See identical proteins and their annotated locations for NP_113931.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      O54701, O54706
      UniProtKB/TrEMBL
      A0A8I6GKF7, A6KRB1
      Related
      ENSRNOP00000010827.6, ENSRNOT00000010827.8
      Conserved Domains (2) summary
      TIGR00367
      Location:138 → 652
      TIGR00367; K+-dependent Na+/Ca+ exchanger related-protein
      pfam01699
      Location:139 → 281
      Na_Ca_ex; Sodium/calcium exchanger protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      106543867..106787810 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288506.1 → XP_063144576.1  sodium/potassium/calcium exchanger 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GKF7

    2. XM_063288505.1 → XP_063144575.1  sodium/potassium/calcium exchanger 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GKF7

    3. XM_063288508.1 → XP_063144578.1  sodium/potassium/calcium exchanger 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GKF7
      Related
      ENSRNOP00000074180.2, ENSRNOT00000083373.3

    4. XM_063288507.1 → XP_063144577.1  sodium/potassium/calcium exchanger 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GKF7

    5. XM_063288501.1 → XP_063144571.1  sodium/potassium/calcium exchanger 2 isoform X1

      UniProtKB/Swiss-Prot
      O54701, O54706
      UniProtKB/TrEMBL
      A0A8I6GKF7, A6KRB1

    6. XM_063288509.1 → XP_063144579.1  sodium/potassium/calcium exchanger 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GKF7

    7. XM_063288503.1 → XP_063144573.1  sodium/potassium/calcium exchanger 2 isoform X1

      UniProtKB/Swiss-Prot
      O54701, O54706
      UniProtKB/TrEMBL
      A0A8I6GKF7, A6KRB1

    8. XM_063288502.1 → XP_063144572.1  sodium/potassium/calcium exchanger 2 isoform X1

      UniProtKB/Swiss-Prot
      O54701, O54706
      UniProtKB/TrEMBL
      A0A8I6GKF7, A6KRB1

    9. XM_063288504.1 → XP_063144574.1  sodium/potassium/calcium exchanger 2 isoform X1

      UniProtKB/Swiss-Prot
      O54701, O54706
      UniProtKB/TrEMBL
      A0A8I6GKF7, A6KRB1

    10. XM_063288510.1 → XP_063144580.1  sodium/potassium/calcium exchanger 2 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O54701.1 GenPept UniProtKB/Swiss-Prot:O54701

    Gene LinkOut

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