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    nonu-1 Smr domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 184951, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nonu-1
    Official Full Name
    Smr domain-containing protein
    Primary source
    WormBase:WBGene00017811
    Locus tag
    CELE_F26A1.13
    See related
    AllianceGenome:WB:WBGene00017811
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable endonuclease activity. Is expressed in body wall musculature; intestine; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 20; multiple sclerosis; and schizophrenia. Orthologous to several human genes including CNP (2',3'-cyclic nucleotide 3' phosphodiesterase); N4BP2 (NEDD4 binding protein 2); and N4BP2L1 (NEDD4 binding protein 2 like 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nonu-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    9
    Sequence:
    Chromosome: III; NC_003281.10 (4846582..4849907, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ACB domain-containing protein Neighboring gene C-type lectin domain-containing protein Neighboring gene C-type lectin domain-containing protein Neighboring gene Putative forkhead-related transcription factor fkh-5 Neighboring gene Non-structural maintenance of chromosomes element 4 Neighboring gene Cell death protein 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ubiquitination of stalled ribosomes enables mRNA decay via HBS-1 and NONU-1 in vivo. Monem PC, et al. PLoS Genet, 2023 Jan. PMID 36626369, Free PMC Article
    2. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Smr domain-containing protein
    NP_001379779.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4846582..4849907 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001393328.1 → NP_001379779.1  Smr domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19803
      Conserved Domains (2) summary
      smart00463
      Location:575 → 656
      SMR; Small MutS-related domain
      pfam13671
      Location:30 → 134
      AAA_33; AAA domain
    Nucleotide Protein
    Heading Accession and Version

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