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    Prune2 prune homolog 2 with BCH domain [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293823, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prune2provided by RGD
    Official Full Name
    prune homolog 2 with BCH domainprovided by RGD
    Primary source
    RGD:1311350
    See related
    AllianceGenome:RGD:1311350
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bmcc1; RGD1311350
    Summary
    Predicted to enable pyrophosphatase activity. Predicted to be involved in apoptotic process. Predicted to be located in cytosol. Predicted to be active in glutamatergic synapse and presynapse. Orthologous to human PRUNE2 (prune homolog 2 with BCH domain). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 149.8), Brain (RPKM 88.6) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Prune2 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (223779617..224130058)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (214352586..214624848)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (236676963..236947527, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting 13 homolog A Neighboring gene forkhead box B2 Neighboring gene uncharacterized LOC134483972 Neighboring gene acyl-protein thioesterase 1-like Neighboring gene glucosaminyl (N-acetyl) transferase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109425

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables pyrophosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein prune homolog 2
    Names
    BNIP2 motif-containing molecule at the C-terminal region 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419567.2 → NP_001406496.1  protein prune homolog 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6ADU8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      223779617..224130058
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287018.1 → XP_063143088.1  protein prune homolog 2 isoform X12

    2. XM_063287005.1 → XP_063143075.1  protein prune homolog 2 isoform X4

    3. XM_063287004.1 → XP_063143074.1  protein prune homolog 2 isoform X3

    4. XM_063287014.1 → XP_063143084.1  protein prune homolog 2 isoform X9

    5. XM_063287003.1 → XP_063143073.1  protein prune homolog 2 isoform X2

    6. XM_063287013.1 → XP_063143083.1  protein prune homolog 2 isoform X8

    7. XM_063287008.1 → XP_063143078.1  protein prune homolog 2 isoform X6

    8. XM_039101377.2 → XP_038957305.1  protein prune homolog 2 isoform X10

      UniProtKB/TrEMBL
      A0A8I6A8C3
      Conserved Domains (3) summary
      COG1227
      Location:24 → 280
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam12496
      Location:2778 → 2895
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:2897 → 3028
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    9. XM_063287019.1 → XP_063143089.1  protein prune homolog 2 isoform X13

    10. XM_063287002.1 → XP_063143072.1  protein prune homolog 2 isoform X1

    11. XM_063287012.1 → XP_063143082.1  protein prune homolog 2 isoform X7

    12. XM_063287017.1 → XP_063143087.1  protein prune homolog 2 isoform X11

    13. XM_039101373.2 → XP_038957301.1  protein prune homolog 2 isoform X5

      Conserved Domains (3) summary
      COG1227
      Location:24 → 280
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam12496
      Location:2778 → 2894
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:2896 → 3027
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    14. XM_039101378.2 → XP_038957306.1  protein prune homolog 2 isoform X14

      Conserved Domains (2) summary
      COG1227
      Location:24 → 280
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam12496
      Location:2778 → 2889
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2

    RNA

    1. XR_010066330.1 RNA Sequence

    2. XR_010066327.1 RNA Sequence

    3. XR_010066331.1 RNA Sequence

    4. XR_010066329.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001024973.1: Suppressed sequence

      Description
      NM_001024973.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: KIAA0367 (GeneID:23273).
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BJR4.1 GenPept UniProtKB/Swiss-Prot:Q5BJR4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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