Cd244a CD244 molecule A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd244aprovided by MGI
Official Full Name: CD244 molecule Aprovided by MGI
Primary source: MGI:MGI:109294
See related: Ensembl:ENSMUSG00000004709 AllianceGenome:MGI:109294
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2B4; C9.1; Ly90; NAIL; Nmrk; Cd244; NKR2B4; SLAMF4; F730046O15Rik
Summary: Predicted to enable MHC class I protein binding activity. Involved in myeloid dendritic cell activation; natural killer cell activation involved in immune response; and positive regulation of lymphocyte proliferation. Located in external side of plasma membrane. Is expressed in thymus primordium. Human ortholog(s) of this gene implicated in rheumatoid arthritis. Orthologous to human CD244 (CD244 molecule). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in spleen adult (RPKM 1.6), large intestine adult (RPKM 0.7) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H3; 1 79.52 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (171386761..171412884)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (171558718..171585316)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Suppression of adaptive NK cell expansion by macrophage-mediated phagocytosis inhibited by 2B4-CD48.
Title: Suppression of adaptive NK cell expansion by macrophage-mediated phagocytosis inhibited by 2B4-CD48.
2B4: A potential target in Staphylococcus aureus associated allergic inflammation.
Title: 2B4: A potential target in Staphylococcus aureus associated allergic inflammation.
A novel 2B4 receptor leads to worse pregnancy outcomes by facilitating TNF-alpha and IFN-gamma production in dNK cells during Toxoplasma gondii infection.
Title: A novel 2B4 receptor leads to worse pregnancy outcomes by facilitating TNF-α and IFN-γ production in dNK cells during Toxoplasma gondii infection.
SLAMF3 and SLAMF4 are immune checkpoints that constrain macrophage phagocytosis of hematopoietic tumors.
Title: SLAMF3 and SLAMF4 are immune checkpoints that constrain macrophage phagocytosis of hematopoietic tumors.
2B4 but not PD-1 blockade improves mortality in septic animals with preexisting malignancy.
Title: 2B4 but not PD-1 blockade improves mortality in septic animals with preexisting malignancy.
Increased attrition of memory T cells during sepsis requires 2B4.
Title: Increased attrition of memory T cells during sepsis requires 2B4.
Phenotypic analysis revealed an increased frequency of murine EBV homolog-specific CD8(+) T cells expressing the 2B4 coinhibitory receptor in septic animals compared with sham controls.
Title: Sepsis erodes CD8(+) memory T cell-protective immunity against an EBV homolog in a 2B4-dependent manner.
these data indicate that 2B4 signals function to alter T cell glucose metabolism, thereby limiting the proliferation and accumulation of CD8(+) T cells.
Title: 2B4 Mediates Inhibition of CD8(+) T Cell Responses via Attenuation of Glycolysis and Cell Division.
SLAMF4 is a marker of intestinal immune cells which contributes to the protection against enteric pathogens and whose expression is dependent on the presence of the gut microbiota
Title: Gut symbiotic microbes imprint intestinal immune cells with the innate receptor SLAMF4 which contributes to gut immune protection against enteric pathogens.
2B4 expression is increased on CD4+ T cells in septic animals
Title: Cutting Edge: 2B4-Mediated Coinhibition of CD4(+) T Cells Underlies Mortality in Experimental Sepsis.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:495515

NoName (e-PCR)
- UniSTS:489208

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MHC class I protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables MHC class I protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in myeloid dendritic cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in natural killer cell activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in natural killer cell activation involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in natural killer cell activation involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CD8-positive, alpha-beta T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of granzyme B production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inositol phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in membrane raft	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: natural killer cell receptor 2B4

Names: CD244 natural killer cell receptor 2B4; NK cell receptor 2B4; NK cell type I receptor protein 2B4; SLAM family member 4; non-MHC restricted killing associated; signaling lymphocytic activation molecule 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.