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    TPO5 Tpo5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853680, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TPO5
    Official Full Name
    Tpo5p
    Primary source
    SGD:S000001657
    Locus tag
    YKL174C
    See related
    AllianceGenome:SGD:S000001657; FungiDB:YKL174C; VEuPathDB:YKL174C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables polyamine transmembrane transporter activity. Involved in polyamine transport. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TPO5 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (120380..122236, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Lst4p Neighboring gene Zn(2+) transporter ZRT3 Neighboring gene U5 snRNP GTPase SNU114 Neighboring gene Ebp2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Excretion of putrescine and spermidine by the protein encoded by YKL174c (TPO5) in Saccharomyces cerevisiae. Tachihara K, et al. J Biol Chem, 2005 Apr 1. PMID 15668236
    2. Metabolic engineering of Saccharomyces cerevisiae for itaconic acid production. Blazeck J, et al. Appl Microbiol Biotechnol, 2014 Oct. PMID 24997118
    3. A two-hybrid screen of the yeast proteome for Hsp90 interactors uncovers a novel Hsp90 chaperone requirement in the activity of a stress-activated mitogen-activated protein kinase, Slt2p (Mpk1p). Millson SH, et al. Eukaryot Cell, 2005 May. PMID 15879519, Free PMC Article
    4. Heterozygous screen in Saccharomyces cerevisiae identifies dosage-sensitive genes that affect chromosome stability. Strome ED, et al. Genetics, 2008 Mar. PMID 18245329, Free PMC Article
    5. Annotating novel genes by integrating synthetic lethals and genomic information. Schöner D, et al. BMC Syst Biol, 2008 Jan 14. PMID 18194531, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. YKL174c (TPO5) has a role in excretion of putrescine and spermidine
      Title: Excretion of putrescine and spermidine by the protein encoded by YKL174c (TPO5) in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables gamma-aminobutyric acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polyamine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gamma-aminobutyric acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in polyamine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in polyamine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tpo5p
    NP_012747.1
    • Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      120380..122236 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179740.1 → NP_012747.1  TPA: Tpo5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012747.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VX26, P36029
      UniProtKB/TrEMBL
      A6ZZF1, B3LQT1, C7GJ35, C8ZC00, G2WHL8, N1P136
      Conserved Domains (1) summary
      pfam00324
      Location:59 → 531
      AA_permease; Amino acid permease
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36029.1

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