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    Taf4 TBP-associated factor 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39765, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Taf4provided by FlyBase
    Official Full Name
    TBP-associated factor 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0010280
    Locus tag
    Dmel_CG5444
    See related
    AllianceGenome:FB:FBgn0010280
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5444; d110; Dmel\CG5444; dmTAF4; dTAF4; dTAFII110; dTAF[[II]]110; l(3)72Dj; p110; SR3-3; SY3-2 TAF110; TAF; taf110; Taf110; TAF110; taf4; TAF4; TAFII110; TAF[II]110; TAF[[II]]; Taf[[II]]110; TAF[[II]]110; TFIID; TFIID 110
    Summary
    Enables DNA binding activity; DNA-binding transcription factor binding activity; and TFIIA-class transcription factor complex binding activity. Contributes to RNA polymerase II general transcription initiation factor activity. Involved in transcription initiation at RNA polymerase II promoter. Located in nucleus. Part of transcription factor TFIID complex. Is expressed in epithelial cell; epithelium; male accessory gland; seminal vesicle; and testis. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder and spermatogenic failure 13. Orthologous to several human genes including TAF4B (TATA-box binding protein associated factor 4b). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Taf4 in Genome Data Viewer
    Location:
    72D7-72D8; 3-44 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16113212..16121651)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16106312..16114751)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Zinc-finger protein at 72D Neighboring gene Strumpellin Neighboring gene Phosphoglucose mutase 1 Neighboring gene Signal sequence receptor beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Incorporation of Drosophila TAF110 into the yeast TFIID complex does not permit the Sp1 glutamine-rich activation domain to function in vivo. Keaveney M, et al. Genes Cells, 1999 Apr. PMID 10336691
    2. The two activation domains of the CCAAT-binding factor CBF interact with the dTAFII110 component of the Drosophila TFIID complex. Coustry F, et al. Biochem J, 1998 Apr 1. PMID 9512492, Free PMC Article
    3. The cAMP-regulated transcription factor CREB interacts with a component of the TFIID complex. Ferreri K, et al. Proc Natl Acad Sci U S A, 1994 Feb 15. PMID 7906413, Free PMC Article
    4. A glutamine-rich hydrophobic patch in transcription factor Sp1 contacts the dTAFII110 component of the Drosophila TFIID complex and mediates transcriptional activation. Gill G, et al. Proc Natl Acad Sci U S A, 1994 Jan 4. PMID 8278363, Free PMC Article
    5. Identifying mutations in Drosophila genes by direct sequencing of PCR products. Schlag EM, et al. Biotechniques, 1999 Aug. PMID 10457826

    See all (143) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase II general transcription initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables TFIIA-class transcription factor complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated transcription initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase II IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase II promoter IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIID complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIID complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of transcription factor TFIID complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TBP-associated factor 4
    Names
    CG5444-PA
    CG5444-PB
    CG5444-PC
    CG5444-PD
    CG5444-PE
    CG5444-PF
    CG5444-PG
    CG5444-PH
    CG5444-PI
    TATA-associated factor 110
    TBP associated factor 110
    TBP-associated factor
    TBP-associated factor 110
    TBP-associated factor 110kD
    Taf4-PA
    Taf4-PB
    Taf4-PC
    Taf4-PD
    Taf4-PE
    Taf4-PF
    Taf4-PG
    Taf4-PH
    Taf4-PI
    lethal(3)72Dj

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16113212..16121651
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079378.4 → NP_524102.1  TBP-associated factor 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524102.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P47825, P49845, Q0E8E3, Q1LZ31, Q8T9E0, Q9VUY7
      UniProtKB/TrEMBL
      E1JI11
      Related
      FBpp0075205
      Conserved Domains (2) summary
      smart00549
      Location:293 → 383
      TAFH; TAF homology
      pfam05236
      Location:675 → 917
      TAF4; Transcription initiation factor TFIID component TAF4 family

    2. NM_001144486.3 → NP_001137958.1  TBP-associated factor 4, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137958.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z060
      Conserved Domains (2) summary
      smart00549
      Location:460 → 550
      TAFH; TAF homology
      pfam05236
      Location:842 → 1084
      TAF4; Transcription initiation factor TFIID component TAF4 family

    3. NM_001274998.1 → NP_001261927.1  TBP-associated factor 4, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261927.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFP3
      Conserved Domains (2) summary
      smart00549
      Location:334 → 424
      TAFH; TAF homology
      pfam05236
      Location:716 → 958
      TAF4; Transcription initiation factor TFIID component TAF4 family

    4. NM_001274999.1 → NP_001261928.1  TBP-associated factor 4, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261928.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PI76
      Conserved Domains (2) summary
      smart00549
      Location:419 → 509
      TAFH; TAF homology
      pfam05236
      Location:801 → 1043
      TAF4; Transcription initiation factor TFIID component TAF4 family

    5. NM_176333.3 → NP_788511.1  TBP-associated factor 4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788511.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V201
      Related
      FBpp0075207
      Conserved Domains (2) summary
      smart00549
      Location:223 → 313
      TAFH; TAF homology
      pfam05236
      Location:605 → 847
      TAF4; Transcription initiation factor TFIID component TAF4 family

    6. NM_001169982.2 → NP_001163453.1  TBP-associated factor 4, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163453.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P47825, P49845, Q0E8E3, Q1LZ31, Q8T9E0, Q9VUY7
      UniProtKB/TrEMBL
      E1JI11
      Conserved Domains (2) summary
      smart00549
      Location:293 → 383
      TAFH; TAF homology
      pfam05236
      Location:675 → 917
      TAF4; Transcription initiation factor TFIID component TAF4 family

    7. NM_206379.3 → NP_996101.1  TBP-associated factor 4, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996101.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V201
      Conserved Domains (2) summary
      smart00549
      Location:223 → 313
      TAFH; TAF homology
      pfam05236
      Location:605 → 847
      TAF4; Transcription initiation factor TFIID component TAF4 family

    8. NM_168651.3 → NP_730109.1  TBP-associated factor 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730109.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P47825, P49845, Q0E8E3, Q1LZ31, Q8T9E0, Q9VUY7
      UniProtKB/TrEMBL
      E1JI11
      Related
      FBpp0075206
      Conserved Domains (2) summary
      smart00549
      Location:293 → 383
      TAFH; TAF homology
      pfam05236
      Location:675 → 917
      TAF4; Transcription initiation factor TFIID component TAF4 family

    9. NM_001300148.1 → NP_001287077.1  TBP-associated factor 4, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287077.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P47825, P49845, Q0E8E3, Q1LZ31, Q8T9E0, Q9VUY7
      UniProtKB/TrEMBL
      E1JI11
      Conserved Domains (2) summary
      smart00549
      Location:293 → 383
      TAFH; TAF homology
      pfam05236
      Location:675 → 917
      TAF4; Transcription initiation factor TFIID component TAF4 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4V201 A4V201
    B7Z060 B7Z060
    E1JI11 E1JI11
    M9PFP3 M9PFP3
    M9PI76 M9PI76
    P47825.1 P47825

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