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    Sec71 Secretory 71 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34785, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sec71provided by FlyBase
    Official Full Name
    Secretory 71provided by FlyBase
    Primary source
    FLYBASE:FBgn0028538
    Locus tag
    Dmel_CG7578
    See related
    AllianceGenome:FB:FBgn0028538
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS00797.7; BIG1; CG7578; Dmel\CG7578; sec71
    Summary
    Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in Golgi to plasma membrane protein transport; positive regulation of endocytosis; and positive regulation of neuron remodeling. Located in trans-Golgi network. Is expressed in adult head. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to several human genes including ARFGEF2 (ADP ribosylation factor guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sec71 in Genome Data Viewer
    Location:
    34D1-34D1; 2-49 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13793521..13799674)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13793521..13799674)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44847 Neighboring gene Engulfment ABC Transporter in the ovary Neighboring gene uncharacterized protein Neighboring gene Carbonic anhydrase 1 Neighboring gene Adenosine deaminase, tRNA-specific 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sec71 separates Golgi stacks in Drosophila S2 cells. Fujii S, et al. J Cell Sci, 2020 Dec 29. PMID 33262309, Free PMC Article
    2. Patronin/CAMSAP promotes reactivation and regeneration of Drosophila quiescent neural stem cells. Gujar MR, et al. EMBO Rep, 2023 Sep 6. PMID 37440685, Free PMC Article
    3. Phylogenetic analysis of Sec7-domain-containing Arf nucleotide exchangers. Cox R, et al. Mol Biol Cell, 2004 Apr. PMID 14742722, Free PMC Article
    4. Sec71 functions as a GEF for the small GTPase Arf1 to govern dendrite pruning of Drosophila sensory neurons. Wang Y, et al. Development, 2017 May 15. PMID 28420712
    5. The Arf family G protein Arl1 is required for secretory granule biogenesis in Drosophila. Torres IL, et al. J Cell Sci, 2014 May 15. PMID 24610947, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ARF protein signal transduction IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in Golgi to plasma membrane protein transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuron remodeling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of neuron remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    secretory 71
    Names
    CG7578-PA
    Sec71 ortholog
    Sec71-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13793521..13799674
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135831.3 → NP_609675.2  secretory 71 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609675.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NKE8, Q9VJW1
      Related
      FBpp0080114
      Conserved Domains (5) summary
      PLN03076
      Location:13 → 1580
      PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
      pfam01369
      Location:582 → 767
      Sec7; Sec7 domain
      pfam09324
      Location:1080 → 1161
      DUF1981; Domain of unknown function (DUF1981)
      pfam12783
      Location:312 → 465
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
      pfam16213
      Location:30 → 212
      DCB; Dimerization and cyclophilin-binding domain of Mon2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJW1 Q9VJW1

    Gene LinkOut

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