Pde9 Phosphodiesterase 9 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pde9provided by FlyBase
Official Full Name: Phosphodiesterase 9provided by FlyBase
Primary source: FLYBASE:FBgn0259171
Locus tag: Dmel_CG42276
See related: AllianceGenome:FB:FBgn0259171
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1627; CG32648; CG3754; CG3761; CG3765; CG42276; Dmel\CG42276; PDE9
Old locus tag: Dmel_CG32648; Dmel_CG3754
Summary: Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Predicted to be involved in cAMP-mediated signaling and cGMP catabolic process. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human PDE9A (phosphodiesterase 9A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 11C2-11D1; 1-41 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (12785563..12897327, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (12679596..12791360, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Drosophila genome encodes five novel PDE genes in addition to dunce. Predicted PDE sequences of Drosophila show highly conserved critical domains when compared with human PDEs.
Title: Cyclic nucleotide phosphodiesterases in Drosophila melanogaster.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-GMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-nucleotide phosphodiesterase activity	IEA Inferred from Electronic Annotation more info
enables 3',5'-cyclic-nucleotide phosphodiesterase activity	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in cAMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cGMP catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cyclic nucleotide metabolic process	ISM Inferred from Sequence Model more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosphodiesterase 9

Names: CG42276-PB; CG42276-PD; CG42276-PE; CG42276-PF; Pde9-PB; Pde9-PD; Pde9-PE; Pde9-PF

NP_001259495.1

EC 3.1.4.-

EC 3.1.4.17

EC 3.1.4.35

NP_001259496.1

EC 3.1.4.-

EC 3.1.4.17

EC 3.1.4.35

NP_572834.2

EC 3.1.4.-

EC 3.1.4.17

EC 3.1.4.35

NP_727644.3

EC 3.1.4.-

EC 3.1.4.17

EC 3.1.4.35

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

12785563..12897327 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001272567.2 → NP_001259496.1 phosphodiesterase 9, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259496.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9I7S6

Conserved Domains (1) summary

pfam00233
Location:739 → 967

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_132606.5 → NP_572834.2 phosphodiesterase 9, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_572834.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9I7S6

Conserved Domains (1) summary

pfam00233
Location:739 → 967

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_167340.5 → NP_727644.3 phosphodiesterase 9, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727644.3

Status: REVIEWED

UniProtKB/TrEMBL

Q9VYJ0

Conserved Domains (1) summary

pfam00233
Location:739 → 967

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
NM_001272566.1 → NP_001259495.1 phosphodiesterase 9, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259495.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9I7S6

Conserved Domains (1) summary

pfam00233
Location:739 → 967

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase