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    RfC4 Replication factor C subunit 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38492, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RfC4provided by FlyBase
    Official Full Name
    Replication factor C subunit 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0260985
    Locus tag
    Dmel_CG14999
    See related
    AllianceGenome:FB:FBgn0260985
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    154910_at; BEST:GH24992; CG14999; Dmel\CG14999; DmRFC4; l(3)64Ai; l(3)A1; l(3)dsl-1; l(3)dsl1; l(3)e20; l(3)Rfc4; l(3)rfc40; l(3)SG13; l(3)SH17; rfc; RfC2; rfc4; Rfc4; rfc40; Rfc40; RfC40; RFC40; rfc[40]
    Summary
    Enables DNA binding activity. Involved in DNA damage checkpoint signaling; DNA replication; and DNA replication checkpoint signaling. Located in nucleus. Part of Elg1 RFC-like complex. Is expressed in several structures, including adult head; antennal primordium; central brain primordium; head epidermis primordium; and stem cell. Orthologous to human RFC2 (replication factor C subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RfC4 in Genome Data Viewer
    Location:
    64A7-64A7; 3-10 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4134860..4136038, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4134860..4136038, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Chd64 Neighboring gene ensconsin Neighboring gene Ras opposite Neighboring gene Ras oncogene at 64B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in the Drosophila Rop gene suggest a function in general secretion and synaptic transmission. Harrison SD, et al. Neuron, 1994 Sep. PMID 7917291
    2. Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen. Mossi R, et al. J Biol Chem, 1997 Jan 17. PMID 8999859
    3. Loss of cell cycle checkpoint control in Drosophila Rfc4 mutants. Krause SA, et al. Mol Cell Biol, 2001 Aug. PMID 11438670, Free PMC Article
    4. The role of DNA replication in chromosome condensation. Pflumm MF. Bioessays, 2002 May. PMID 12001264
    5. Structure-specific abnormalities associated with mutations in a DNA replication accessory factor in Drosophila. Jaffe AB, et al. Dev Biol, 2001 Feb 15. PMID 11161570

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    contributes_to DNA clamp loader activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to DNA clamp loader activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA repair TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA replication TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in DNA replication checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA strand elongation involved in DNA replication TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leading strand elongation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sister chromatid cohesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA replication factor C complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of DNA replication factor C complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of Elg1 RFC-like complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    replication factor C subunit 4
    Names
    CG14999-PA
    Replication-factor-C 40kD subunit
    RfC4-PA
    lethal (3) SG13

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4134860..4136038 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079191.3 → NP_523915.1  replication factor C subunit 4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523915.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P53034, Q9VZH9
      Related
      FBpp0073120
      Conserved Domains (3) summary
      cd00009
      Location:31 → 165
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      PLN03025
      Location:16 → 330
      PLN03025; replication factor C subunit; Provisional
      pfam08542
      Location:254 → 322
      Rep_fac_C; Replication factor C C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53034.1 P53034

    Gene LinkOut

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