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    Prp6 pre-mRNA processing factor 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40064, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prp6provided by FlyBase
    Official Full Name
    pre-mRNA processing factor 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0036828
    Locus tag
    Dmel_CG6841
    See related
    AllianceGenome:FB:FBgn0036828
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD43276; CG6841; Dmel\CG6841
    Summary
    Predicted to enable RNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including adult head; larval imaginal tissue; and trunk mesoderm. Human ortholog(s) of this gene implicated in retinitis pigmentosa 60. Orthologous to human PRPF6 (pre-mRNA processing factor 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Prp6 in Genome Data Viewer
    Location:
    75E4-75E5; 3-45 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18905372..18908974)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18898472..18902001)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene COP9 signalosome subunit 1b Neighboring gene Cytochrome c oxidase subunit 6A-like 2 Neighboring gene Ionotropic receptor 75d Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptomic comparison of Drosophila snRNP biogenesis mutants reveals mutant-specific changes in pre-mRNA processing: implications for spinal muscular atrophy. Garcia EL, et al. RNA, 2016 Aug. PMID 27268418, Free PMC Article
    2. The splicing co-factor Barricade/Tat-SF1 is required for cell cycle and lineage progression in Drosophila neural stem cells. Abramczuk MK, et al. Development, 2017 Nov 1. PMID 28935704
    3. Comparative transcriptomics across 14 Drosophila species reveals signatures of longevity. Ma S, et al. Aging Cell, 2018 Aug. PMID 29671950, Free PMC Article
    4. Drosophila melanogaster: A Valuable Genetic Model Organism to Elucidate the Biology of Retinitis Pigmentosa. Lehmann M, et al. Methods Mol Biol, 2019. PMID 30324448
    5. Identification of alternative splicing regulators by RNA interference in Drosophila. Park JW, et al. Proc Natl Acad Sci U S A, 2004 Nov 9. PMID 15492211, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome HMP PubMed 
    involved_in spliceosomal tri-snRNP complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of U4/U6 x U5 tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome HDA PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    pre-mRNA processing factor 6
    Names
    CG6841-PA
    CG6841-PB
    Prp6-PA
    Prp6-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      18905372..18908974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316442.1 → NP_001303371.1  pre-mRNA processing factor 6, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVU6
      Conserved Domains (5) summary
      smart00386
      Location:434 → 466
      HAT; HAT (Half-A-TPR) repeats
      COG0457
      Location:543 → 803
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:698 → 728
      TPR; TPR repeat [structural motif]
      pfam06424
      Location:22 → 173
      PRP1_N; PRP1 splicing factor, N-terminal
      pfam13428
      Location:665 → 708
      TPR_14; Tetratricopeptide repeat

    2. NM_140816.3 → NP_649073.1  pre-mRNA processing factor 6, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649073.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVU6
      Related
      FBpp0074835
      Conserved Domains (5) summary
      smart00386
      Location:434 → 466
      HAT; HAT (Half-A-TPR) repeats
      COG0457
      Location:543 → 803
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:698 → 728
      TPR; TPR repeat [structural motif]
      pfam06424
      Location:22 → 173
      PRP1_N; PRP1 splicing factor, N-terminal
      pfam13428
      Location:665 → 708
      TPR_14; Tetratricopeptide repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SX58 Q8SX58
    Q9VVU6 Q9VVU6

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