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    zyd zydeco [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3354992, updated on 9-Dec-2024

    Summary

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    Official Symbol
    zydprovided by FlyBase
    Official Full Name
    zydecoprovided by FlyBase
    Primary source
    FLYBASE:FBgn0265767
    Locus tag
    Dmel_CG2893
    See related
    AllianceGenome:FB:FBgn0265767
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:CK02262; CG2893; CG40147; CK02262; Dmel\CG2893; Nckx-x; Ncxk-x
    Summary
    Predicted to enable calcium channel activity and calcium, potassium:sodium antiporter activity. Involved in calcium ion transmembrane transport and calcium-mediated signaling. Located in plasma membrane. Is expressed in several structures, including CNS glial cell; adult head; ganglia; larval nervous system; and ventral midline of embryo. Used to study epilepsy. Human ortholog(s) of this gene implicated in amelogenesis imperfecta hypomaturation type 2A5 and pigmentation disease. Orthologous to human SLC24A3 (solute carrier family 24 member 3) and SLC24A4 (solute carrier family 24 member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See zyd in Genome Data Viewer
    Location:
    20F4-20F4; 1-66 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (23022898..23035550)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) XHet NW_001848859.1 (2135..14368)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Rab21 Neighboring gene Cytochrome c oxidase assembly factor 7 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization, functional expression and tissue distribution of a second NCKX Na+/Ca2+ -K+ exchanger from Drosophila. Winkfein RJ, et al. Cell Calcium, 2004 Aug. PMID 15193862
    2. Genome-wide transcriptional changes associated with enhanced activity in the Drosophila nervous system. Guan Z, et al. Neuron, 2005 Oct 6. PMID 16202711
    3. A Functional Study of Mutations in K+-dependent Na+-Ca2+ Exchangers Associated with Amelogenesis Imperfecta and Non-syndromic Oculocutaneous Albinism. Jalloul AH, et al. J Biol Chem, 2016 Jun 17. PMID 27129268, Free PMC Article
    4. Mutation of a NCKX eliminates glial microdomain calcium oscillations and enhances seizure susceptibility. Melom JE, et al. J Neurosci, 2013 Jan 16. PMID 23325253, Free PMC Article
    5. SIK3 and Wnk converge on Fray to regulate glial K+ buffering and seizure susceptibility. Lones L, et al. PLoS Genet, 2023 Jan. PMID 36626385, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium, potassium:sodium antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zydeco
    Names
    CG2893-PA
    CG2893-PD
    CG2893-PE
    CG2893-PF
    CG2893-PG
    CG2893-PH
    CG2893-PI
    zyd-PA
    zyd-PD
    zyd-PE
    zyd-PF
    zyd-PG
    zyd-PH
    zyd-PI

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      23022898..23035550
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316629.1 → NP_001303558.1  zydeco, isoform I [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5LJX7
      Conserved Domains (1) summary
      pfam01699
      Location:291 → 446
      Na_Ca_ex; Sodium/calcium exchanger protein

    2. NM_001015260.3 → NP_001015260.3  zydeco, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001015260.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5LJX9, Q8SXS9
      Conserved Domains (2) summary
      COG0530
      Location:39 → 515
      ECM27; Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]
      pfam01699
      Location:41 → 185
      Na_Ca_ex; Sodium/calcium exchanger protein

    3. NM_001015261.3 → NP_001015261.3  zydeco, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001015261.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5LJX8
      Conserved Domains (2) summary
      COG0530
      Location:46 → 522
      ECM27; Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]
      pfam01699
      Location:48 → 192
      Na_Ca_ex; Sodium/calcium exchanger protein

    4. NM_001300714.1 → NP_001287643.1  zydeco, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287643.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A021WZA4
      Conserved Domains (2) summary
      COG0530
      Location:30 → 479
      ECM27; Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]
      pfam01699
      Location:32 → 176
      Na_Ca_ex; Sodium/calcium exchanger protein

    5. NM_001015263.3 → NP_001015263.1  zydeco, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001015263.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5LJX7
      Conserved Domains (1) summary
      pfam01699
      Location:291 → 446
      Na_Ca_ex; Sodium/calcium exchanger protein

    6. NM_001300715.1 → NP_001287644.1  zydeco, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287644.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5LJX7
      Conserved Domains (1) summary
      pfam01699
      Location:291 → 446
      Na_Ca_ex; Sodium/calcium exchanger protein

    7. NM_001015262.3 → NP_001015262.1  zydeco, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001015262.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7PLW1
      Conserved Domains (2) summary
      COG0530
      Location:30 → 506
      ECM27; Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]
      pfam01699
      Location:32 → 176
      Na_Ca_ex; Sodium/calcium exchanger protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A021WZA4 A0A021WZA4
    Q5LJX7 Q5LJX7
    Q5LJX8 Q5LJX8
    Q7PLW1 Q7PLW1
    Q8SXS9 Q8SXS9

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