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    CCDC151 Coiled-coil domain containing protein 151 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39345, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CCDC151provided by FlyBase
    Official Full Name
    Coiled-coil domain containing protein 151provided by FlyBase
    Primary source
    FLYBASE:FBgn0036219
    Locus tag
    Dmel_CG14127
    See related
    AllianceGenome:FB:FBgn0036219
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Ccdc151; CG14127; Dmel\CG14127
    Summary
    Involved in negative gravitaxis. Located in several cellular components, including cell body; ciliary rootlet; and ciliary tip. Is expressed in chordotonal neurons and chordotonal organ. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 30. Orthologous to human ODAD3 (outer dynein arm docking complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CCDC151 in Genome Data Viewer
    Location:
    68E3-68E3; 3-37 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11881384..11883546)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11874484..11876646)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene snoRNA:Orphan H/ACA box 8 Neighboring gene Spermitin Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The coiled-coil domain containing protein CCDC151 is required for the function of IFT-dependent motile cilia in animals. Jerber J, et al. Hum Mol Genet, 2014 Feb 1. PMID 24067530
    2. The dynamics of protein localisation to restricted zones within Drosophila mechanosensory cilia. Xiang W, et al. Sci Rep, 2022 Aug 3. PMID 35922464, Free PMC Article
    3. Imaging cilia in Drosophila melanogaster. Vieillard J, et al. Methods Cell Biol, 2015. PMID 25837397
    4. Identification of conserved transcriptome features between humans and Drosophila in the aging brain utilizing machine learning on combined data from the NIH Sequence Read Archive. Webb JL, et al. PLoS One, 2021. PMID 34379632, Free PMC Article
    5. Survey of the Ciliary Motility Machinery of Drosophila Sperm and Ciliated Mechanosensory Neurons Reveals Unexpected Cell-Type Specific Variations: A Model for Motile Ciliopathies. Zur Lage P, et al. Front Genet, 2019. PMID 30774648, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CCDC151 protein expression is restricted to motile cilia that require intraflagellar transport for their assembly in Drosophila.
      Title: The coiled-coil domain containing protein CCDC151 is required for the function of IFT-dependent motile cilia in animals.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in axonemal dynein complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in cilium movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cilium movement ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in negative gravitaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in outer dynein arm assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in outer dynein arm assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in ciliary rootlet IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary rootlet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in ciliary tip IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Coiled-coil domain containing protein 151
    Names
    CCDC151-PA
    CG14127-PA
    Ccdc151

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11881384..11883546
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140263.1 → NP_648520.1  Coiled-coil domain containing protein 151 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648520.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VTQ3
      Related
      FBpp0075769, FBtr0076037
      Conserved Domains (1) summary
      TIGR02168
      Location:175 → 425
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VTQ3 Q9VTQ3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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