U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    let-711 CCR4-NOT transcription complex subunit let-711 [ Caenorhabditis elegans ]

    Gene ID: 175971, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    let-711
    Official Full Name
    CCR4-NOT transcription complex subunit let-711
    Primary source
    WormBase:WBGene00002845
    Locus tag
    CELE_F57B9.2
    See related
    AllianceGenome:WB:WBGene00002845
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable molecular adaptor activity. Involved in several processes, including microtubule cytoskeleton organization; nematode larval development; and post-transcriptional regulation of gene expression. Located in cytoplasm. Part of CCR4-NOT complex. Is expressed in germ line; gonad; and in male. Human ortholog(s) of this gene implicated in Vissers-Bodmer syndrome and holoprosencephaly 12. Orthologous to human CNOT1 (CCR4-NOT transcription complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See let-711 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    18
    Sequence:
    Chromosome: III; NC_003281.10 (6946718..6958894)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene RNA helicase Neighboring gene Activated in Blocked Unfolded protein response Neighboring gene ncRNA Neighboring gene putative 26S proteasome regulatory subunit rpn-6.1 Neighboring gene Putative pyridoxamine 5'-phosphate oxidase

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. let-711 is required for spindle positioning in the early embryo
      Title: LET-711, the Caenorhabditis elegans NOT1 ortholog, is required for spindle positioning and regulation of microtubule length in embryos.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in astral microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of mitotic spindle localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA poly(A) tail shortening IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of CCR4-NOT complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of CCR4-NOT core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CCR4-NOT core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    CCR4-NOT transcription complex subunit let-711
    NP_001333557.1
    • Confirmed by transcript evidence
    NP_001333558.1
    • Confirmed by transcript evidence
    NP_001333559.1
    • Confirmed by transcript evidence
    NP_001368611.1
    • Confirmed by transcript evidence
    NP_498516.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6946718..6958894
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066115.6 → NP_498516.3  CCR4-NOT transcription complex subunit let-711 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498516.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1D3PCL8, A0A1D3PCL9, A0A1D3PCM5, Q20937, S5ZDJ9
      Conserved Domains (4) summary
      PHA03378
      Location:832 → 990
      PHA03378; EBNA-3B; Provisional
      COG5103
      Location:1035 → 2602
      CDC39; Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]
      pfam04054
      Location:2235 → 2599
      Not1; CCR4-Not complex component, Not1
      pfam16418
      Location:592 → 743
      CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat

    2. NM_001379782.1 → NP_001368611.1  CCR4-NOT transcription complex subunit let-711 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (4) summary
      PHA03378
      Location:815 → 973
      PHA03378; EBNA-3B; Provisional
      COG5103
      Location:1018 → 2585
      CDC39; Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]
      pfam04054
      Location:2218 → 2582
      Not1; CCR4-Not complex component, Not1
      pfam16418
      Location:575 → 726
      CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat

    3. NM_001346615.3 → NP_001333557.1  CCR4-NOT transcription complex subunit let-711 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1D3PCL8
      Conserved Domains (4) summary
      PHA03378
      Location:525 → 683
      PHA03378; EBNA-3B; Provisional
      COG5103
      Location:728 → 2295
      CDC39; Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]
      pfam04054
      Location:1935 → 2292
      Not1; CCR4-Not complex component, Not1
      pfam16418
      Location:285 → 436
      CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat

    4. NM_001346616.3 → NP_001333558.1  CCR4-NOT transcription complex subunit let-711 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      S5ZDJ9
      Conserved Domains (3) summary
      PHA03378
      Location:66 → 197
      PHA03378; EBNA-3B; Provisional
      COG5103
      Location:269 → 1836
      CDC39; Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]
      pfam04054
      Location:1476 → 1833
      Not1; CCR4-Not complex component, Not1

    5. NM_001346617.3 → NP_001333559.1  CCR4-NOT transcription complex subunit let-711 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1D3PCL9
      Conserved Domains (1) summary
      pfam04054
      Location:1 → 215
      Not1; CCR4-Not complex component, Not1
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials