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    alpha-Man-IIa alpha-Mannosidase class II a [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41126, updated on 9-Dec-2024

    Summary

    Official Symbol
    alpha-Man-IIaprovided by FlyBase
    Official Full Name
    alpha-Mannosidase class II aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011740
    Locus tag
    Dmel_CG18802
    See related
    AllianceGenome:FB:FBgn0011740
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    agr;-Man-II; alpha-Man-II; alpha-Man-IIA; alpha-Man-IIalpha; CG18474; CG18802; CG8139; dGMII; dGMIIb; DM-GII.1; Dmel\CG18802; GmII; GMII; Man; MAN-2; Man-II
    Summary
    Enables mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity. Involved in N-glycan processing; encapsulation of foreign target; and rhodopsin biosynthetic process. Located in Golgi membrane. Is expressed in adult head; embryonic brain; larval ventral nerve cord; and organism. Orthologous to several human genes including MAN2A2 (mannosidase alpha class 2A member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See alpha-Man-IIa in Genome Data Viewer
    Location:
    85D15-85D16; 3-48 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9412548..9417264)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5238270..5242986)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene beta-Tubulin at 85D Neighboring gene TWIK-related acid-sensitive K[+] channel 7 Neighboring gene pasilla Neighboring gene Glutathione S transferase Z1

    Genomic regions, transcripts, and products

    Bibliography

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in N-glycan processing  
    involved_in N-glycan processing PubMed 
    involved_in encapsulation of foreign target PubMed 
    involved_in mannose metabolic process  
    involved_in rhodopsin biosynthetic process PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi membrane  
    located_in Golgi membrane PubMed 
    located_in Golgi stack PubMed 
    located_in endoplasmic reticulum PubMed 

    General protein information

    Preferred Names
    alpha-Mannosidase class II a
    Names
    CG18802-PA
    CG18802-PB
    alpha mannosidase II
    alpha-Man-IIa-PA
    alpha-Man-IIa-PB
    alpha-mannosidase 2
    alpha-mannosidase II
    alpha-mannosidase-II
    chain A, golgi Alpha-Mannosidase Ii
    golgi Man II
    golgi alpha-mannosidase
    golgi alpha-mannosidase II
    golgi mannosidase II
    mannosidase II
    NP_001262413.1
    NP_524291.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9412548..9417264
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275484.1 → NP_001262413.1  alpha-Mannosidase class II a, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262413.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFG0
      Conserved Domains (3) summary
      cd10809
      Location:144 → 483
      GH38N_AMII_GMII_SfManIII_like; N-terminal catalytic domain of Golgi alpha-mannosidase II, Spodoptera frugiperda Sf9 alpha-mannosidase III, and similar proteins; glycoside hydrolase family 38 (GH38)
      smart00872
      Location:478 → 554
      Alpha-mann_mid; Alpha mannosidase, middle domain
      pfam07748
      Location:744 → 1103
      Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
    2. NM_079567.3 → NP_524291.2  alpha-Mannosidase class II a, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524291.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24451, Q9TYG5, Q9VHD8, Q9VHD9
      Related
      FBpp0081509
      Conserved Domains (3) summary
      cd10809
      Location:143 → 482
      GH38N_AMII_GMII_SfManIII_like; N-terminal catalytic domain of Golgi alpha-mannosidase II, Spodoptera frugiperda Sf9 alpha-mannosidase III, and similar proteins; glycoside hydrolase family 38 (GH38)
      smart00872
      Location:477 → 553
      Alpha-mann_mid; Alpha mannosidase, middle domain
      pfam07748
      Location:743 → 1102
      Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
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