chinmo Chronologically inappropriate morphogenesis [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: chinmoprovided by FlyBase
Official Full Name: Chronologically inappropriate morphogenesisprovided by FlyBase
Primary source: FLYBASE:FBgn0086758
Locus tag: Dmel_CG31666
See related: AllianceGenome:FB:FBgn0086758
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10871; CG17156; CG17649; CG31666; Chinmo; Dmel\CG31666; F; l(2)04111
Summary: Involved in several processes, including male somatic sex determination; nervous system development; and positive regulation of actin filament polymerization. Located in nucleus. Is expressed in several structures, including head epidermis primordium; imaginal disc; sensory nervous system primordium; somatic cell of testis; and ventral nerve cord. Used to study brain cancer. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 22A5-22B1; 2-3 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (1651258..1704682)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (1651258..1704682)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chigno/CG11180 and SUMO are Chinmo-interacting proteins with a role in Drosophila testes somatic support cells.
Title: Chigno/CG11180 and SUMO are Chinmo-interacting proteins with a role in Drosophila testes somatic support cells.
Chinmo is the larval member of the molecular trinity that directs Drosophila metamorphosis.
Title: Chinmo is the larval member of the molecular trinity that directs Drosophila metamorphosis.
chinmo-mutant spermatogonial stem cells cause mitotic drive by evicting non-mutant neighbors from the niche.
Title: chinmo-mutant spermatogonial stem cells cause mitotic drive by evicting non-mutant neighbors from the niche.
miR-125-chinmo pathway regulates dietary restriction-dependent enhancement of lifespan in Drosophila.
Title: miR-125-chinmo pathway regulates dietary restriction-dependent enhancement of lifespan in Drosophila.
let-7-Complex MicroRNAs Regulate Broad-Z3, Which Together with Chinmo Maintains Adult Lineage Neurons in an Immature State.
Title: let-7-Complex MicroRNAs Regulate Broad-Z3, Which Together with Chinmo Maintains Adult Lineage Neurons in an Immature State.
Developmental regulation of regenerative potential in Drosophila by ecdysone through a bistable loop of ZBTB transcription factors Chinmo and Broad.
Title: Developmental regulation of regenerative potential in Drosophila by ecdysone through a bistable loop of ZBTB transcription factors.
The BTB-zinc finger factor Chinmo acts upstream of ecdysone signaling to promote a neuronal fate switch. Indeed, Chinmo regulates the expression of the ecdysone receptor B1 isoform to mediate the production of gamma and alpha'beta' MB neurons
Title: Steroid Hormone Ecdysone Signaling Specifies Mushroom Body Neuron Sequential Fate via Chinmo.
Transcriptional control of the sex determination hierarchy by Chinmo is critical for sex maintenance in sexually dimorphic tissues and is vital in the preservation of fertility.
Title: Chinmo prevents transformer alternative splicing to maintain male sex identity.
Neuroepithelium differentiation in late larvae requires the transcriptional silencing of chinmo by ecdysone, the main steroid hormone, therefore allowing coordination of neural stem cell self-renewal with organismal growth.
Title: Two distinct mechanisms silence chinmo in Drosophila neuroblasts and neuroepithelial cells to limit their self-renewal.
we show that two co-transcribed Drosophila miRNAs, let-7 and miR-125, non-redundantly regulate a common target, the transcription factor Chronologically Inappropriate Morphogenesis (Chinmo). We first characterize novel adult phenotypes associated with loss of both let-7 and miR-125, which are derived from a common, polycistronic transcript that also encodes a third miRNA, miR-100.
Title: A let-7-to-miR-125 MicroRNA Switch Regulates Neuronal Integrity and Lifespan in Drosophila.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0225 (e-PCR)
- UniSTS:34701

Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 1679032-1686439 mobile_element_type = transposon:blood{}289

Gene Ontology Provided by FlyBase

Process	Evidence Code	Pubs
involved_in eye-antennal disc development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male somatic sex determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mushroom body development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to caloric restriction	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: chronologically inappropriate morphogenesis

Names: CG31666-PA; CG31666-PD; CG31666-PE; CG31666-PF; CG31666-PG; CG31666-PH; chinmo; chinmo-PA; chinmo-PD; chinmo-PE; chinmo-PF; chinmo-PG; chinmo-PH; chronologically -inappropriate morphogenesis; lethal (2) 04111

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

1651258..1704682

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001258910.2 → NP_001245839.1 chronologically inappropriate morphogenesis, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245839.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8IGM8, Q9VQ30, Q9VQ31

Conserved Domains (3) summary

smart00225
Location:33 → 116

BTB; Broad-Complex, Tramtrack and Bric a brac

sd00017
Location:519 → 540

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00651
Location:22 → 116

BTB; BTB/POZ domain
NM_001201751.2 → NP_001188680.1 chronologically inappropriate morphogenesis, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188680.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KU09

Conserved Domains (3) summary

smart00225
Location:33 → 116

BTB; Broad-Complex, Tramtrack and Bric a brac

sd00017
Location:519 → 540

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00651
Location:22 → 116

BTB; BTB/POZ domain
NM_164429.3 → NP_722718.1 chronologically inappropriate morphogenesis, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_722718.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8IGM8, Q9VQ30, Q9VQ31

Related

FBpp0292934

Conserved Domains (3) summary

smart00225
Location:33 → 116

BTB; Broad-Complex, Tramtrack and Bric a brac

sd00017
Location:519 → 540

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00651
Location:22 → 116

BTB; BTB/POZ domain
NM_164430.4 → NP_722719.1 chronologically inappropriate morphogenesis, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_722719.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8IGM8, Q9VQ30, Q9VQ31

Related

FBpp0077545

Conserved Domains (3) summary

smart00225
Location:33 → 116

BTB; Broad-Complex, Tramtrack and Bric a brac

sd00017
Location:519 → 540

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00651
Location:22 → 116

BTB; BTB/POZ domain
NM_164428.3 → NP_722717.2 chronologically inappropriate morphogenesis, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_722717.2

Status: REVIEWED

UniProtKB/TrEMBL

Q7KU09

Conserved Domains (3) summary

smart00225
Location:33 → 116

BTB; Broad-Complex, Tramtrack and Bric a brac

sd00017
Location:519 → 540

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00651
Location:22 → 116

BTB; BTB/POZ domain
NM_134766.6 → NP_608610.1 chronologically inappropriate morphogenesis, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_608610.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8IGM8, Q9VQ30, Q9VQ31

Related

FBpp0077546

Conserved Domains (3) summary

smart00225
Location:33 → 116

BTB; Broad-Complex, Tramtrack and Bric a brac

sd00017
Location:519 → 540

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00651
Location:22 → 116

BTB; BTB/POZ domain