Tao Tao [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Taoprovided by FlyBase
Official Full Name: Taoprovided by FlyBase
Primary source: FLYBASE:FBgn0031030
Locus tag: Dmel_CG14217
See related: AllianceGenome:FB:FBgn0031030
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AAF48973; CG14217; Dmel\CG14217; dTao-1; MARKK; tao; tao-1; Tao-1; TAO-1; tao1; Tao1; TAO1
Summary: Enables protein serine/threonine kinase activity. Involved in several processes, including negative regulation of developmental growth; nervous system development; and regulation of signal transduction. Located in several cellular components, including basal part of cell; microtubule cytoskeleton; and perikaryon. Is expressed in several structures, including adult head; central brain primordium; ganglia; germline cell; and pole plasm. Used to study autism spectrum disorder; cancer; central nervous system disease; and chromosome 16p11.2 deletion syndrome, 593-kb. Orthologous to human TAOK1 (TAO kinase 1); TAOK2 (TAO kinase 2); and TAOK3 (TAO kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 18D1-18D3; 1-63 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (19569721..19579800, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (19463754..19473833, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Developing neuromuscular junction (NMJ) neuronal loss of the serine-threonine protein kinase Tao, a regulator of the Hippo signaling pathway, results in supernumerary boutons which contain a normal density of active zones. Tao is also required for proper synaptic function, as reduction of Tao results in NMJs with decreased evoked excitatory junctional potentials.
Title: Tao Negatively Regulates BMP Signaling During Neuromuscular Junction Development in Drosophila.
Study in transgenic Drosophila melanogaster larvae identified the conserved Ste20-like kinase Tao as a negative regulator of synaptic growth required for maintenance of circuit specificity and connectivity. Loss of Tao kinase resulted in exuberant postsynaptic specializations and aberrant connectivity during larval growth.
Title: Maintenance of cell type-specific connectivity and circuit function requires Tao kinase.
Tao-1 kinase regulates GckIII kinase activity to control tracheal morphogenesis.
Title: A Hippo-like Signaling Pathway Controls Tracheal Morphogenesis in Drosophila melanogaster.
Schip1 directly links Ex to Hpo signaling by recruiting Tao-1
Title: Drosophila Schip1 Links Expanded and Tao-1 to Regulate Hippo Signaling.
Tao-S acts as an antagonist of Tao-L both in tissue culture cells and in transgenic animals, indicating that the tao-1 gene encodes two proteins with opposing functions on the cytoskeletal architecture.
Title: Drosophila gene tao-1 encodes proteins with and without a Ste20 kinase domain that affect cytoskeletal architecture and cell migration differently.
the sterile-like 20 kinase, Tao, controls tissue homeostasis by regulating the Hippo pathway in the Drosophila adult midgut
Title: The sterile 20-like kinase tao controls tissue homeostasis by regulating the hippo pathway in Drosophila adult midgut.
A mutation in the gene Tao results in the loss of cuboidal to squamous epithelial cell transition.
Title: Tao controls epithelial morphogenesis by promoting Fasciclin 2 endocytosis.
Tao-1 functions together with Hippo to activate Warts-mediated repression of Yorkie
Title: The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway.
Tao-1 is as a component of the Hippo-Salvador-Warts pathway signaling, and therefore tissue growth, during development.
Title: Tao-1 phosphorylates Hippo/MST kinases to regulate the Hippo-Salvador-Warts tumor suppressor pathway.
These data reveal a role for Tao-1 in controlling the dynamic interplay between microtubule plus ends and the actin cortex in the regulation of cell form.
Title: Tao-1 is a negative regulator of microtubule plus-end growth.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in R8 cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central complex development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intestinal stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hippo signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of stress-activated MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in response to cocaine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to nicotine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tissue homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in basal part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Tao

Names: CG14217-PA; CG14217-PB; CG14217-PD; CG14217-PE; CG14217-PF; CG14217-PG; CG14217-PH; CG14217-PI; CG14217-PJ; Tao-1; Tao-PA; Tao-PB; Tao-PD; Tao-PE; Tao-PF; Tao-PG; Tao-PH; Tao-PI; Tao-PJ; Tao1

NP_001188672.1

EC 2.7.11.1

NP_001188673.1

EC 2.7.11.1

NP_001245756.1

EC 2.7.11.1

NP_001259708.1

EC 2.7.11.1

NP_001259709.1

EC 2.7.11.1

NP_608319.1

EC 2.7.11.1

NP_728267.1

EC 2.7.11.1

NP_728268.1

EC 2.7.11.1

NP_728269.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

19569721..19579800 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001201743.3 → NP_001188672.1 Tao, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188672.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0KHQ5, Q8T093

Conserved Domains (2) summary

smart00220
Location:27 → 280

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06607
Location:25 → 282

STKc_TAO; Catalytic domain of the Serine/Threonine Kinases, Thousand-and-One Amino acids proteins
NM_001201744.2 → NP_001188673.1 Tao, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188673.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0KHQ5

Conserved Domains (1) summary

PTZ00121
Location:44 → 401

PTZ00121; MAEBL; Provisional
NM_167665.2 → NP_728267.1 Tao, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728267.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0KHQ5, Q8T093

Related

FBpp0074541

Conserved Domains (2) summary

smart00220
Location:27 → 280

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06607
Location:25 → 282

STKc_TAO; Catalytic domain of the Serine/Threonine Kinases, Thousand-and-One Amino acids proteins
NM_167666.3 → NP_728268.1 Tao, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728268.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0KHQ5, Q8T093

Related

FBpp0074540

Conserved Domains (2) summary

smart00220
Location:27 → 280

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06607
Location:25 → 282

STKc_TAO; Catalytic domain of the Serine/Threonine Kinases, Thousand-and-One Amino acids proteins
NM_001272779.1 → NP_001259708.1 Tao, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259708.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PHK2

Conserved Domains (2) summary

smart00220
Location:27 → 279

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06607
Location:25 → 281

STKc_TAO; Catalytic domain of the Serine/Threonine Kinases, Thousand-and-One Amino acids proteins
NM_134475.4 → NP_608319.1 Tao, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_608319.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0KHQ5

Related

FBpp0074543

Conserved Domains (1) summary

PTZ00121
Location:44 → 401

PTZ00121; MAEBL; Provisional
NM_167667.3 → NP_728269.1 Tao, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728269.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IQW6

Related

FBpp0074542

Conserved Domains (1) summary

PTZ00121
Location:21 → 378

PTZ00121; MAEBL; Provisional
NM_001272780.2 → NP_001259709.1 Tao, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259709.1

Status: REVIEWED

UniProtKB/TrEMBL

C8VV09, M9PI11

Conserved Domains (2) summary

smart00220
Location:27 → 280

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06607
Location:25 → 282

STKc_TAO; Catalytic domain of the Serine/Threonine Kinases, Thousand-and-One Amino acids proteins
NM_001258827.1 → NP_001245756.1 Tao, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245756.1

Status: REVIEWED

UniProtKB/TrEMBL

C8VV09, M9NE33

Conserved Domains (2) summary

smart00220
Location:27 → 280

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06607
Location:25 → 282

STKc_TAO; Catalytic domain of the Serine/Threonine Kinases, Thousand-and-One Amino acids proteins