PHO11 acid phosphatase PHO11 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PHO11
Official Full Name: acid phosphatase PHO11
Primary source: SGD:S000000094
Locus tag: YAR071W
See related: AllianceGenome:SGD:S000000094; FungiDB:YAR071W; VEuPathDB:YAR071W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables acid phosphatase activity. Predicted to be involved in phosphate-containing compound metabolic process. Located in extracellular region. Human ortholog(s) of this gene implicated in papillary thyroid carcinoma and pontocerebellar hypoplasia type 16. Orthologous to human MINPP1 (multiple inositol-polyphosphate phosphatase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PHO11 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 1

Sequence:: Chromosome: I; NC_001133.9 (225460..226863)

Chromosome I - NC_001133.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables acid phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acid phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables acid phosphatase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in phosphate-containing compound metabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in fungal-type cell wall	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: acid phosphatase PHO11

NP_009434.1

EC 3.1.3.2

One of three repressible acid phosphatases; glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2; PHO11 has a paralog, PHO12, that arose from a segmental duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001133.9 Reference assembly

Range

225460..226863

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178239.1 → NP_009434.1 TPA: acid phosphatase PHO11 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009434.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VPP1, P35842

UniProtKB/TrEMBL

A6ZSK2, B5VKE4

Conserved Domains (1) summary

pfam00328
Location:65 → 399

His_Phos_2; Histidine phosphatase superfamily (branch 2)