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    Sgpl1 sphingosine phosphate lyase 1 [ Mus musculus (house mouse) ]

    Gene ID: 20397, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sgpl1provided by MGI
    Official Full Name
    sphingosine phosphate lyase 1provided by MGI
    Primary source
    MGI:MGI:1261415
    See related
    Ensembl:ENSMUSG00000020097 AllianceGenome:MGI:1261415
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Spl; S1PL; D10Xrf456
    Summary
    Predicted to enable sphinganine-1-phosphate aldolase activity. Acts upstream of or within several processes, including face morphogenesis; gonad development; and vasculogenesis. Located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in nephrotic syndrome type 14. Orthologous to human SGPL1 (sphingosine-1-phosphate lyase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 37.5), large intestine adult (RPKM 19.5) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Sgpl1 in Genome Data Viewer
    Location:
    10 B4; 10 32.14 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (60934421..60983463, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (61098642..61147684, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene 20611 Neighboring gene pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1 Neighboring gene STARR-positive B cell enhancer ABC_E8337 Neighboring gene STARR-positive B cell enhancer mm9_chr10:60610293-60610594 Neighboring gene STARR-seq mESC enhancer starr_26826 Neighboring gene thymus, brain and testes associated Neighboring gene STARR-positive B cell enhancer mm9_chr10:60662268-60662569 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 14 Neighboring gene predicted gene, 29861

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables pyridoxal phosphate binding  
    enables sphinganine-1-phosphate aldolase activity  
    enables sphinganine-1-phosphate aldolase activity  
    enables sphinganine-1-phosphate aldolase activity  
    Items 1 - 25 of 26
    Process Evidence Code Pubs
    acts_upstream_of_or_within Leydig cell differentiation PubMed 
    acts_upstream_of_or_within androgen metabolic process PubMed 
    involved_in apoptotic signaling pathway  
    involved_in apoptotic signaling pathway  
    involved_in ceramide metabolic process  
    involved_in ceramide metabolic process  
    acts_upstream_of_or_within estrogen metabolic process PubMed 
    acts_upstream_of_or_within excretion PubMed 
    acts_upstream_of_or_within face morphogenesis PubMed 
    involved_in fatty acid metabolic process  
    involved_in fatty acid metabolic process  
    acts_upstream_of_or_within female gonad development PubMed 
    acts_upstream_of_or_within fibroblast migration PubMed 
    acts_upstream_of_or_within hemopoiesis PubMed 
    acts_upstream_of_or_within kidney development PubMed 
    acts_upstream_of_or_within luteinization PubMed 
    acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway PubMed 
    acts_upstream_of_or_within post-embryonic development PubMed 
    acts_upstream_of_or_within regulation of multicellular organism growth PubMed 
    acts_upstream_of_or_within roof of mouth development PubMed 
    acts_upstream_of_or_within skeletal system morphogenesis PubMed 
    acts_upstream_of_or_within spermatogenesis PubMed 
    involved_in sphingolipid catabolic process  
    involved_in sphingolipid catabolic process  
    involved_in sphingolipid catabolic process  
    acts_upstream_of_or_within vasculogenesis PubMed 
    Items 1 - 25 of 26
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum  
    located_in endoplasmic reticulum PubMed 
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane  

    General protein information

    Preferred Names
    sphingosine-1-phosphate lyase 1
    Names
    SP-lyase 1
    SPL 1
    sphingosine-1-phosphate aldolase
    NP_001303602.1
    NP_001303603.1
    NP_033189.2
    XP_017169349.1
    XP_036011604.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316673.1NP_001303602.1  sphingosine-1-phosphate lyase 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AC123530, AI428538, AK049342, BB854743
      Consensus CDS
      CCDS35914.1
      UniProtKB/Swiss-Prot
      O54955, Q8C942, Q8R0X7
      UniProtKB/TrEMBL
      Q3UDJ2, Q4FK38
      Related
      ENSMUSP00000090155.6, ENSMUST00000092498.12
      Conserved Domains (1) summary
      cd06450
      Location:146507
      DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
    2. NM_001316674.1NP_001303603.1  sphingosine-1-phosphate lyase 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AC123530, AI428538, AK036747, BB854743, CD554088
      Consensus CDS
      CCDS35914.1
      UniProtKB/Swiss-Prot
      O54955, Q8C942, Q8R0X7
      UniProtKB/TrEMBL
      Q3UDJ2, Q4FK38
      Conserved Domains (1) summary
      cd06450
      Location:146507
      DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
    3. NM_009163.4NP_033189.2  sphingosine-1-phosphate lyase 1

      See identical proteins and their annotated locations for NP_033189.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AC123530, AI428538, AK036747, BB620054, BB854743
      Consensus CDS
      CCDS35914.1
      UniProtKB/Swiss-Prot
      O54955, Q8C942, Q8R0X7
      UniProtKB/TrEMBL
      Q3UDJ2, Q4FK38
      Related
      ENSMUSP00000112975.2, ENSMUST00000122259.8
      Conserved Domains (1) summary
      cd06450
      Location:146507
      DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      60934421..60983463 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155711.1XP_036011604.1  sphingosine-1-phosphate lyase 1 isoform X1

      UniProtKB/Swiss-Prot
      O54955, Q8C942, Q8R0X7
      UniProtKB/TrEMBL
      Q3UDJ2, Q4FK38
      Conserved Domains (1) summary
      cd06450
      Location:146507
      DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
    2. XM_017313860.3XP_017169349.1  sphingosine-1-phosphate lyase 1 isoform X1

      UniProtKB/Swiss-Prot
      O54955, Q8C942, Q8R0X7
      UniProtKB/TrEMBL
      Q3UDJ2, Q4FK38
      Conserved Domains (1) summary
      cd06450
      Location:146507
      DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
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