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    Ttc7 Tetratricopeptide repeat domain 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 48387, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ttc7provided by FlyBase
    Official Full Name
    Tetratricopeptide repeat domain 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0021847
    Locus tag
    Dmel_CG8325
    See related
    AllianceGenome:FB:FBgn0021847
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD21719; CG8325; Dmel\CG8325; dTTC7; l(2)k14710; l(2)k15603; ttc7; TTC7; YPP1
    Summary
    Predicted to be involved in phosphatidylinositol phosphate biosynthetic process and protein localization to plasma membrane. Predicted to be active in plasma membrane. Is expressed in adult head; organism; and spermatozoon. Human ortholog(s) of this gene implicated in multiple intestinal atresia. Orthologous to several human genes including TTC7A (tetratricopeptide repeat domain 7A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ttc7 in Genome Data Viewer
    Location:
    42A13-42A13; 2-55 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6209782..6214122, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2097287..2101627, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44161 Neighboring gene bicoid-interacting protein 3 Neighboring gene tomboy40

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TTC7 and Hyccin Regulate Neuronal Aβ42 Accumulation and its Associated Neural Deficits in Aβ42-Expressing Drosophila. Sun M, et al. J Alzheimers Dis, 2018. PMID 30103315
    2. Hyccin/FAM126A deficiency reduces glial enrichment and axonal sheath, which are rescued by overexpression of a plasma membrane-targeting PI4KIIIα in Drosophila. Zhang Q, et al. Biochem Biophys Res Commun, 2022 Jan 22. PMID 34894559
    3. A PI4KIIIα protein complex is required for cell viability during Drosophila wing development. Basu U, et al. Dev Biol, 2020 Jun 15. PMID 32194035, Free PMC Article
    4. Position Effects Influence Transvection in Drosophila melanogaster. King TD, et al. Genetics, 2019 Dec. PMID 31611231, Free PMC Article
    5. Regulation of PI4P levels by PI4KIIIα during G-protein-coupled PLC signaling in Drosophila photoreceptors. Balakrishnan SS, et al. J Cell Sci, 2018 Aug 3. PMID 29980590, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tetratricopeptide repeat domain 7
    Names
    CG8325-PA
    CG8325-PB
    Ttc7-PA
    Ttc7-PB
    lethal (2) k14710

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6209782..6214122 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259218.2 → NP_001246147.1  tetratricopeptide repeat domain 7, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246147.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7H0
      Conserved Domains (4) summary
      COG0457
      Location:408 → 626
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:703 → 731
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:772 → 836
      TPR_11; TPR repeat
      pfam13428
      Location:772 → 814
      TPR_14; Tetratricopeptide repeat

    2. NM_143806.4 → NP_652063.1  tetratricopeptide repeat domain 7, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652063.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KN74
      Related
      FBpp0085344
      Conserved Domains (4) summary
      COG0457
      Location:408 → 626
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:713 → 741
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:782 → 846
      TPR_11; TPR repeat
      pfam13428
      Location:782 → 824
      TPR_14; Tetratricopeptide repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K7H0 A0A0B4K7H0
    Q7KN74 Q7KN74

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