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    Dnai2 dynein, axonemal, intermediate chain 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39318, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dnai2provided by FlyBase
    Official Full Name
    dynein, axonemal, intermediate chain 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0036195
    Locus tag
    Dmel_CG6053
    See related
    AllianceGenome:FB:FBgn0036195
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6053; Dmel\CG6053
    Summary
    Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Involved in several processes, including outer dynein arm assembly; response to auditory stimulus; and sperm competition. Located in dendrite and neuronal cell body. Is expressed in Johnston organ neurons; chordotonal neurons; femoral chordotonal organ; and larval abdominal lch5 neuron. Used to study sensorineural hearing loss. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 9. Orthologous to human DNAI2 (dynein axonemal intermediate chain 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dnai2 in Genome Data Viewer
    Location:
    68D2-68D2; 3-36 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11697126..11699263, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11690226..11692363, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43887 Neighboring gene Diphthamide biosynthesis 1 Neighboring gene uncharacterized protein Neighboring gene Coiled-coil domain containing 56 Neighboring gene Mitochondrial Transcription Factor B1 Neighboring gene crimpled

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Downregulation of TOP2 modulates neurodegeneration caused by GGGGCC expanded repeats. Jiao B, et al. Hum Mol Genet, 2021 May 29. PMID 33749734
    2. Diverse Roles of Axonemal Dyneins in Drosophila Auditory Neuron Function and Mechanical Amplification in Hearing. Karak S, et al. Sci Rep, 2015 Nov 26. PMID 26608786, Free PMC Article
    3. Dyneins across eukaryotes: a comparative genomic analysis. Wickstead B, et al. Traffic, 2007 Dec. PMID 17897317, Free PMC Article
    4. Genes underlying species differences in cuticular hydrocarbon production between Drosophila melanogaster and D. simulans. Ward HKE, et al. Genome, 2021 Feb. PMID 33211537
    5. Decoding cilia function: defining specialized genes required for compartmentalized cilia biogenesis. Avidor-Reiss T, et al. Cell, 2004 May 14. PMID 15137945

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dynein heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium movement ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in outer dynein arm assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in outer dynein arm assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to auditory stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm competition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of outer dynein arm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of outer dynein arm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    dynein, axonemal, intermediate chain 2
    Names
    CG6053-PB
    CG6053-PC
    Dnai2-PB
    Dnai2-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11697126..11699263 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274794.1 → NP_001261723.1  dynein, axonemal, intermediate chain 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261723.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PC80, Q4V560
      Conserved Domains (3) summary
      COG2319
      Location:160 → 482
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:162 → 208
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:212 → 469
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_140240.2 → NP_648497.2  dynein, axonemal, intermediate chain 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648497.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V560, Q9VTM3
      Conserved Domains (3) summary
      COG2319
      Location:160 → 482
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:162 → 208
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:212 → 469
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PC80 M9PC80
    Q9VTM3 Q9VTM3

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