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    rept reptin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40092, updated on 27-Dec-2024

    Summary

    Official Symbol
    reptprovided by FlyBase
    Official Full Name
    reptinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040075
    Locus tag
    Dmel_CG9750
    See related
    AllianceGenome:FB:FBgn0040075
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0142479.1; CG9750; Dmel\CG9750; drep; dRep; dReptin; dRUVBL2; l(3)06945; psg10; Q9V3K3_DROME; rep; REP; Rept; REPT; Reptin; Tip48; Tip48/Reptin
    Summary
    Enables transcription corepressor activity. Involved in several processes, including autophagic cell death; chromatin remodeling; and negative regulation of canonical Wnt signaling pathway. Located in nucleus. Part of Ino80 complex; NuA4 histone acetyltransferase complex; and R2TP complex. Is expressed in several structures, including adult head; antennal primordium; embryonic/larval midgut primordium; head epidermis primordium; and sensory nervous system primordium. Orthologous to human RUVBL2 (RuvB like AAA ATPase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See rept in Genome Data Viewer
    Location:
    76A3-76A3; 3-45 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19255340..19257111)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19248440..19250211)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46216 Neighboring gene mitochondrial ribosomal protein L21 Neighboring gene antisense RNA:CR45210 Neighboring gene nessy Neighboring gene Blocked early in transport 1 Neighboring gene Max

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATP-dependent activity, acting on DNA  
    enables DNA helicase activity  
    enables protein binding PubMed 
    enables transcription corepressor activity PubMed 
    Component Evidence Code Pubs
    part_of Ino80 complex  
    part_of Ino80 complex PubMed 
    part_of NuA4 histone acetyltransferase complex  
    part_of NuA4 histone acetyltransferase complex PubMed 
    part_of R2TP complex  
    part_of R2TP complex PubMed 
    part_of Swr1 complex  
    part_of histone acetyltransferase complex PubMed 
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    reptin
    Names
    CG9750-PA
    CG9750-PB
    CG9750-PC
    dReptin
    rept-PA
    rept-PB
    rept-PC

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19255340..19257111
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079432.3 → NP_524156.1  reptin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524156.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V3K3
      UniProtKB/TrEMBL
      M9PFN1
      Related
      FBpp0074756
      Conserved Domains (3) summary
      cd00009
      Location:267 → 358
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      pfam06068
      Location:17 → 408
      TIP49; TIP49 C-terminus
      cl21455
      Location:69 → 113
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. NM_001300184.1 → NP_001287113.1  reptin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287113.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V3K3
      UniProtKB/TrEMBL
      M9PFN1
      Conserved Domains (3) summary
      cd00009
      Location:267 → 358
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      pfam06068
      Location:17 → 408
      TIP49; TIP49 C-terminus
      cl21455
      Location:69 → 113
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    3. NM_001275111.1 → NP_001262040.1  reptin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262040.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V3K3
      UniProtKB/TrEMBL
      M9PFN1
      Conserved Domains (3) summary
      cd00009
      Location:267 → 358
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      pfam06068
      Location:17 → 408
      TIP49; TIP49 C-terminus
      cl21455
      Location:69 → 113
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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