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    PF3D7_1467300 1-deoxy-D-xylulose 5-phosphate reductoisomerase [ Plasmodium falciparum 3D7 ]

    Gene ID: 812223, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_1467300
    Gene description
    1-deoxy-D-xylulose 5-phosphate reductoisomerase
    Locus tag
    PF3D7_1467300
    See related
    PlasmoDB:PF3D7_1467300; VEuPathDB:PF3D7_1467300
    Gene type
    protein coding
    RNA name
    1-deoxy-D-xylulose 5-phosphate reductoisomerase
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_1467300 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    1
    Sequence:
    Chromosome: 14; NC_037283.1 (2750958..2752424)

    Chromosome 14 - NC_037283.1Genomic Context describing neighboring genes Neighboring gene DNA-3-methyladenine glycosylase, putative Neighboring gene WD repeat-containing protein 79, putative Neighboring gene 50S ribosomal protein L22, apicoplast, putative Neighboring gene DNA/RNA-binding protein KIN17, putative

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037283.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In silico identification of promiscuous scaffolds as potential inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase for treatment of Falciparum malaria. Wadood A, et al. Pharm Biol, 2017 Dec. PMID 27650666, Free PMC Article
    2. Molecular basis of fosmidomycin's action on the human malaria parasite Plasmodium falciparum. Umeda T, et al. Sci Rep, 2011. PMID 22355528, Free PMC Article
    3. Fosmidomycin uptake into Plasmodium and Babesia-infected erythrocytes is facilitated by parasite-induced new permeability pathways. Baumeister S, et al. PLoS One, 2011 May 4. PMID 21573242, Free PMC Article
    4. The malarial drug target Plasmodium falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase (PfDXR): development of a 3-D model for identification of novel, structural and functional features and for inhibitor screening. Goble JL, et al. Protein Pept Lett, 2010 Jan. PMID 20214634
    5. Functional genetic analysis of the Plasmodium falciparum deoxyxylulose 5-phosphate reductoisomerase gene. Odom AR, et al. Mol Biochem Parasitol, 2010 Apr. PMID 20018214, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Innovative scaffolds with novel modes of action, improved efficacy and acceptable physiochemical/pharmacokinetic properties were computationally identified as potential inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase for treatment of Falciparum malaria.
      Title: In silico identification of promiscuous scaffolds as potential inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase for treatment of Falciparum malaria.
    2. Data indicate that IspC (1-deoxy-D-xylulose 5-phosphate reductoisomerase) displays a high level of enantioselectivity for an alpha-substituted fosmidomycin derivative.
      Title: IspC as target for antiinfective drug discovery: synthesis, enantiomeric separation, and structural biology of fosmidomycin thia isosters.
    3. A three-dimensional model of the malarial drug target protein PfDXR was generated, and validated using structure-checking programs and protein docking studies.
      Title: The malarial drug target Plasmodium falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase (PfDXR): development of a 3-D model for identification of novel, structural and functional features and for inhibitor screening.
    4. These data indicate that deoxyxylulose 5-phosphate reductoisomerase is required for intraerythrocytic development of Plasmodium falciparum.
      Title: Functional genetic analysis of the Plasmodium falciparum deoxyxylulose 5-phosphate reductoisomerase gene.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Process Evidence Code Pubs
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apicoplast HDA PubMed 
    located_in apicoplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    1-deoxy-D-xylulose 5-phosphate reductoisomerase
    Names
    MEP synthase
    XP_001348815.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037283.1 Reference assembly

      Range
      2750958..2752424
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001348779.1 → XP_001348815.1  1-deoxy-D-xylulose 5-phosphate reductoisomerase [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001348815.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      A0A144A2T4, O96693, Q8IKG4
      UniProtKB/TrEMBL
      A0A024UY83, A0A024VJS7, A0A024WHA3, A0A024X1G0, A0A0L1I9Z9, W4I8U8, W4IWG8, W7F391, W7FQT1, W7JFS8, W7JLE6
      Conserved Domains (1) summary
      PRK05447
      Location:79 → 485
      PRK05447; 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IKG4.1

    Gene LinkOut

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