U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    mngR DNA-binding transcriptional repressor MngR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945371, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    mngR
    Official Full Name
    DNA-binding transcriptional repressor MngR
    Primary source
    ECOCYC:EG11109
    Locus tag
    b0730
    See related
    ASAP:ABE-0002487
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0718; farR; ybgB
    Summary
    Originally identifed as a fatty acyl-responsive regulator FarR based on in vitro experiments; this conclusion is now in doubt based on microarray experiments. [More information is available at EcoGene: EG11109]. According to microarray analysis, the "mannosyl-d-glycerate regulator," MngR, regulates only two genes, mngA and mngB, involved in 2-O--mannosyl-d-glycerate utilization . [More information is available at EcoCyc: EG11109].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (765153..765875, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene succinyl-CoA synthetase subunit beta Neighboring gene succinyl-CoA synthetase subunit alpha Neighboring gene ncRNA Neighboring gene 2-O-alpha-mannosyl-D-glycerate specific PTS enzyme II Neighboring gene alpha-mannosidase

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Identification of a fatty acyl responsive regulator (FarR) in Escherichia coli. Quail MA, et al. FEBS Lett, 1994 Dec 19. PMID 7805834
    2. Isolation and characterization of the heat-responsive genes in Escherichia coli. Utsumi R, et al. Biosci Biotechnol Biochem, 1996 Feb. PMID 9063979
    3. Overexpression and site-directed mutagenesis of the succinyl-CoA synthetase of Escherichia coli and nucleotide sequence of a gene (g30) that is adjacent to the suc operon. Buck D, et al. Biochem J, 1989 Jun 15. PMID 2548486, Free PMC Article
    4. Phosphotransferase-mediated transport of the osmolyte 2-O-alpha-mannosyl-D-glycerate in Escherichia coli occurs by the product of the mngA (hrsA) gene and is regulated by the mngR (farR) gene product acting as repressor. Sampaio MM, et al. J Biol Chem, 2004 Feb 13. PMID 14645248
    5. Inferring gene function from evolutionary change in signatures of translation efficiency. Krisko A, et al. Genome Biol, 2014 Mar 3. PMID 24580753, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    DNA-binding transcriptional repressor MngR

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      765153..765875 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415258.1 DNA-binding transcriptional repressor MngR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415258.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1P5H7
      Conserved Domains (1) summary
      PRK09764
      Location:1 → 240
      PRK09764; GntR family transcriptional regulator
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.