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    Tbx3 T-box 3 [ Mus musculus (house mouse) ]

    Gene ID: 21386, updated on 4-Jan-2025

    Summary

    Official Symbol
    Tbx3provided by MGI
    Official Full Name
    T-box 3provided by MGI
    Primary source
    MGI:MGI:98495
    See related
    Ensembl:ENSMUSG00000018604 AllianceGenome:MGI:98495
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D5Ertd189e
    Summary
    Enables DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including atrioventricular canal morphogenesis; embryonic morphogenesis; and regulation of protein complex stability. Acts upstream of or within several processes, including circulatory system development; mammary gland morphogenesis; and regulation of DNA-templated transcription. Located in nucleus. Part of transcription regulator complex. Is active in cilium. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study ulnar-mammary syndrome. Human ortholog(s) of this gene implicated in ulnar-mammary syndrome. Orthologous to human TBX3 (T-box transcription factor 3). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in adrenal adult (RPKM 118.3), small intestine adult (RPKM 47.5) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Tbx3 in Genome Data Viewer
    Location:
    5 F; 5 60.34 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (119808600..119822789)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (119670534..119684724)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene T-box 3, opposite strand 1 Neighboring gene predicted gene 16063 Neighboring gene enhancer eA upstream of Tbx3 Neighboring gene predicted gene 16064 Neighboring gene STARR-seq mESC enhancer starr_14224 Neighboring gene T-box 3, opposite strand 2 Neighboring gene STARR-seq mESC enhancer starr_14227 Neighboring gene STARR-seq mESC enhancer starr_14229 Neighboring gene STARR-seq mESC enhancer starr_14230 Neighboring gene predicted gene, 42017

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II-specific DNA-binding transcription factor binding PubMed 
    enables protein binding PubMed 
    enables sequence-specific DNA binding  
    enables sequence-specific DNA binding  
    enables sequence-specific double-stranded DNA binding  
    Items 1 - 25 of 91
    Process Evidence Code Pubs
    acts_upstream_of DNA-templated transcription PubMed 
    acts_upstream_of_or_within animal organ morphogenesis PubMed 
    involved_in anterior/posterior axis specification, embryo  
    involved_in anterior/posterior axis specification, embryo  
    acts_upstream_of_or_within atrioventricular bundle cell differentiation PubMed 
    involved_in atrioventricular canal development PubMed 
    involved_in atrioventricular canal morphogenesis PubMed 
    acts_upstream_of_or_within blood vessel development PubMed 
    acts_upstream_of_or_within branching involved in mammary gland duct morphogenesis PubMed 
    involved_in cardiac epithelial to mesenchymal transition  
    involved_in cardiac epithelial to mesenchymal transition  
    involved_in cardiac jelly development  
    involved_in cardiac jelly development  
    acts_upstream_of_or_within cardiac muscle cell differentiation PubMed 
    acts_upstream_of_or_within cardiac muscle cell fate commitment PubMed 
    involved_in cell fate specification  
    acts_upstream_of_or_within cellular senescence PubMed 
    involved_in cellular senescence  
    involved_in cellular senescence  
    acts_upstream_of_or_within embryonic digit morphogenesis PubMed 
    involved_in embryonic digit morphogenesis PubMed 
    involved_in embryonic digit morphogenesis  
    involved_in embryonic digit morphogenesis  
    involved_in embryonic forelimb morphogenesis  
    involved_in embryonic forelimb morphogenesis  
    acts_upstream_of_or_within embryonic heart tube development PubMed 
    acts_upstream_of_or_within embryonic hindlimb morphogenesis PubMed 
    involved_in endocardial cushion formation  
    involved_in endocardial cushion formation  
    involved_in female genitalia development  
    involved_in female genitalia development  
    involved_in follicle-stimulating hormone secretion  
    involved_in follicle-stimulating hormone secretion  
    acts_upstream_of_or_within forelimb morphogenesis PubMed 
    acts_upstream_of_or_within heart looping PubMed 
    acts_upstream_of_or_within heart morphogenesis PubMed 
    acts_upstream_of hepatoblast differentiation PubMed 
    acts_upstream_of_or_within in utero embryonic development PubMed 
    involved_in inner ear morphogenesis PubMed 
    acts_upstream_of_or_within limb morphogenesis PubMed 
    involved_in limb morphogenesis PubMed 
    acts_upstream_of_or_within limbic system development PubMed 
    involved_in luteinizing hormone secretion  
    involved_in luteinizing hormone secretion  
    involved_in male genitalia development  
    involved_in male genitalia development  
    acts_upstream_of_or_within mammary gland development PubMed 
    involved_in mammary gland development  
    acts_upstream_of_or_within mammary placode formation PubMed 
    acts_upstream_of_or_within mammary placode formation PubMed 
    involved_in mesoderm morphogenesis  
    involved_in mesoderm morphogenesis  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription PubMed 
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of cell proliferation involved in heart morphogenesis  
    involved_in negative regulation of cell proliferation involved in heart morphogenesis  
    acts_upstream_of_or_within negative regulation of epithelial cell differentiation PubMed 
    involved_in negative regulation of myoblast differentiation  
    involved_in negative regulation of myoblast differentiation  
    acts_upstream_of_or_within negative regulation of stem cell differentiation PubMed 
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within outflow tract morphogenesis PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of cell cycle  
    involved_in positive regulation of cell cycle  
    involved_in positive regulation of cell population proliferation  
    acts_upstream_of_or_within positive regulation of stem cell proliferation PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within regulation of cell population proliferation PubMed 
    involved_in regulation of protein complex stability PubMed 
    involved_in regulation of protein stability PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within roof of mouth development PubMed 
    involved_in semicircular canal morphogenesis PubMed 
    acts_upstream_of_or_within sinoatrial node cell development PubMed 
    involved_in sinoatrial node cell development  
    involved_in skeletal system development  
    involved_in skeletal system development  
    acts_upstream_of_or_within smooth muscle cell differentiation PubMed 
    acts_upstream_of_or_within specification of animal organ position PubMed 
    acts_upstream_of_or_within stem cell population maintenance PubMed 
    acts_upstream_of stem cell proliferation PubMed 
    acts_upstream_of_or_within ureteric peristalsis PubMed 
    acts_upstream_of_or_within ventricular septum morphogenesis PubMed 
    Items 1 - 25 of 91
    Component Evidence Code Pubs
    located_in chromatin  
    is_active_in cilium PubMed 
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in nucleus  
    part_of transcription regulator complex PubMed 

    General protein information

    Preferred Names
    T-box transcription factor TBX3
    Names
    T-box protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011535.3NP_035665.2  T-box transcription factor TBX3 isoform 1

      See identical proteins and their annotated locations for NP_035665.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA543734, AK052453, AK145436, BB054411, BB694449, BB728182, CJ216213
      Consensus CDS
      CCDS19613.1
      UniProtKB/Swiss-Prot
      E9QM97, P70324, Q60708, Q8BWH7
      UniProtKB/TrEMBL
      Q3ULL3
      Related
      ENSMUSP00000018748.9, ENSMUST00000018748.9
      Conserved Domains (2) summary
      pfam00907
      Location:105305
      T-box
      pfam12598
      Location:323402
      TBX; T-box transcription factor
    2. NM_198052.2NP_932169.1  T-box transcription factor TBX3 isoform 2

      See identical proteins and their annotated locations for NP_932169.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AA543734, BB054411, BB694449, BB728182, BC096551, CJ216213
      Consensus CDS
      CCDS19614.1
      UniProtKB/TrEMBL
      Q3U043, Q4VA43
      Related
      ENSMUSP00000112519.2, ENSMUST00000121021.8
      Conserved Domains (2) summary
      pfam12598
      Location:303391
      TBX; T-box transcription factor
      cd00182
      Location:102287
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      119808600..119822789
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530276.5XP_006530339.1  T-box transcription factor TBX3 isoform X1

      See identical proteins and their annotated locations for XP_006530339.1

      UniProtKB/Swiss-Prot
      E9QM97, P70324, Q60708, Q8BWH7
      UniProtKB/TrEMBL
      Q3ULL3
      Conserved Domains (2) summary
      pfam00907
      Location:105305
      T-box
      pfam12598
      Location:323402
      TBX; T-box transcription factor
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