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    Elys elys [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32971, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Elysprovided by FlyBase
    Official Full Name
    elysprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031052
    Locus tag
    Dmel_CG14215
    See related
    AllianceGenome:FB:FBgn0031052
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14215; dElys; Dmel\CG14215; elys; ELYS
    Summary
    Enables chromatin DNA binding activity. Part of nuclear pore. Is expressed in adult head and spermatozoon. Orthologous to human AHCTF1 (AT-hook containing transcription factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Elys in Genome Data Viewer
    Location:
    18D13-18D13; 1-63 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19652305..19659407)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19546338..19553440)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Actin-related protein 10 Neighboring gene Ranbp21 Neighboring gene uncharacterized protein Neighboring gene Ssu72 CTD phosphatase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nucleoporin Elys attaches peripheral chromatin to the nuclear pores in interphase nuclei. Doronin SA, et al. Commun Biol, 2024 Jun 29. PMID 38951619, Free PMC Article
    2. A negative loop within the nuclear pore complex controls global chromatin organization. Breuer M, et al. Genes Dev, 2015 Sep 1. PMID 26341556, Free PMC Article
    3. Piwi interacts with chromatin at nuclear pores and promiscuously binds nuclear transcripts in Drosophila ovarian somatic cells. Ilyin AA, et al. Nucleic Acids Res, 2017 Jul 27. PMID 28472469, Free PMC Article
    4. Genetic Analyses of Elys Mutations in Drosophila Show Maternal-Effect Lethality and Interactions with Nucleoporin Genes. Hirai K, et al. G3 (Bethesda), 2018 Jul 2. PMID 29773558, Free PMC Article
    5. Chromatin targeting of nuclear pore proteins induces chromatin decondensation. Kuhn TM, et al. J Cell Biol, 2019 Sep 2. PMID 31366666, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    elys
    Names
    CG14215-PA
    CG14215-PB
    Elys-PA
    Elys-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19652305..19659407
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134496.3 → NP_608340.2  elys, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608340.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95TR2, Q9VWE6
      UniProtKB/TrEMBL
      X2JG50
      Related
      FBpp0074515
      Conserved Domains (2) summary
      pfam13934
      Location:713 → 917
      ELYS; Nuclear pore complex assembly
      pfam16687
      Location:166 → 482
      ELYS-bb; beta-propeller of ELYS nucleoporin

    2. NM_001298525.1 → NP_001285454.1  elys, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285454.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95TR2, Q9VWE6
      UniProtKB/TrEMBL
      X2JG50
      Conserved Domains (2) summary
      pfam13934
      Location:713 → 917
      ELYS; Nuclear pore complex assembly
      pfam16687
      Location:166 → 482
      ELYS-bb; beta-propeller of ELYS nucleoporin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VWE6.2 Q9VWE6
    X2JG50 X2JG50

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