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    St7 suppression of tumorigenicity 7 [ Mus musculus (house mouse) ]

    Gene ID: 64213, updated on 9-Dec-2024

    Summary

    Official Symbol
    St7provided by MGI
    Official Full Name
    suppression of tumorigenicity 7provided by MGI
    Primary source
    MGI:MGI:1927450
    See related
    Ensembl:ENSMUSG00000029534 AllianceGenome:MGI:1927450
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HELG; RAY1; SEN4; TSG7; Fam4a2; 9430001H04Rik
    Summary
    Predicted to be located in membrane. Is expressed in central nervous system; early conceptus; and secondary oocyte. Orthologous to human ST7 (suppression of tumorigenicity 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 8.2), whole brain E14.5 (RPKM 7.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See St7 in Genome Data Viewer
    Location:
    6 A2; 6 8.0 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (17693579..17943022)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (17693901..17943023)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15256 Neighboring gene predicted gene, 53318 Neighboring gene STARR-positive B cell enhancer ABC_E9662 Neighboring gene capping actin protein of muscle Z-line subunit alpha 2 Neighboring gene STARR-positive B cell enhancer mm9_chr6:17682030-17682331 Neighboring gene four and a half LIM domains 3 pseudogene Neighboring gene metal response element binding transcription factor 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_15259 Neighboring gene STARR-positive B cell enhancer mm9_chr6:17726341-17726642 Neighboring gene predicted gene, 52895 Neighboring gene STARR-seq mESC enhancer starr_15260 Neighboring gene STARR-seq mESC enhancer starr_15261 Neighboring gene STARR-seq mESC enhancer starr_15263 Neighboring gene wingless-type MMTV integration site family, member 2 Neighboring gene ankyrin repeat, SAM and basic leucine zipper domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    suppressor of tumorigenicity 7 protein
    Names
    4low density lipoprotein-related protein 12
    family with sequence similarity 4, subfamily A, member 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083315.2NP_001076784.1  suppressor of tumorigenicity 7 protein isoform 2

      See identical proteins and their annotated locations for NP_001076784.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC068561, AK079107, AK132103
      Consensus CDS
      CCDS39431.1
      UniProtKB/TrEMBL
      D3YUM7
      Related
      ENSMUSP00000111077.4, ENSMUST00000115417.4
      Conserved Domains (1) summary
      cd11557
      Location:11475
      ST7; Suppression of tumorigenicity 7
    2. NM_001289624.1NP_001276553.1  suppressor of tumorigenicity 7 protein isoform 3

      See identical proteins and their annotated locations for NP_001276553.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is longer than isoform 1.
      Source sequence(s)
      AC068561, AC153836
      Consensus CDS
      CCDS71728.1
      UniProtKB/Swiss-Prot
      Q3UA20, Q6Q9W2, Q6Q9W3, Q8R3T3, Q921F6, Q99M89, Q99M90, Q99M91, Q99M92, Q99M93, Q99M94, Q99M96, Q9JID7, Q9JID8
      UniProtKB/TrEMBL
      D3YUM7
      Related
      ENSMUSP00000080341.7, ENSMUST00000081635.13
      Conserved Domains (1) summary
      pfam04184
      Location:19576
      ST7; ST7 protein
    3. NM_001289625.1NP_001276554.1  suppressor of tumorigenicity 7 protein isoform 4

      See identical proteins and their annotated locations for NP_001276554.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, uses an alternate in-frame splice site, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is longer than isoform 1.
      Source sequence(s)
      AC068561, AC153836
      Consensus CDS
      CCDS80490.1
      UniProtKB/TrEMBL
      D3YUM7
      Related
      ENSMUSP00000111079.2, ENSMUST00000115419.8
      Conserved Domains (1) summary
      pfam04184
      Location:19571
      ST7; ST7 protein
    4. NM_001289626.1NP_001276555.1  suppressor of tumorigenicity 7 protein isoform 5

      See identical proteins and their annotated locations for NP_001276555.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region and lacks an alternate in-frame exon, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (5) has a distinct N-terminus and is longer than isoform 1.
      Source sequence(s)
      AC068561, AC153836
      Consensus CDS
      CCDS71729.1
      UniProtKB/TrEMBL
      D3YUM7, Q99M95
      Related
      ENSMUSP00000062886.6, ENSMUST00000052113.12
      Conserved Domains (1) summary
      pfam04184
      Location:19553
      ST7; ST7 protein
    5. NM_001289627.1NP_001276556.1  suppressor of tumorigenicity 7 protein isoform 6

      See identical proteins and their annotated locations for NP_001276556.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (6) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC068561, AC153836
      Consensus CDS
      CCDS71730.1
      UniProtKB/TrEMBL
      D3YUM7
      Related
      ENSMUSP00000076334.3, ENSMUST00000077080.9
      Conserved Domains (1) summary
      pfam04184
      Location:4530
      ST7; ST7 protein
    6. NM_001289629.1NP_001276558.1  suppressor of tumorigenicity 7 protein isoform 7

      See identical proteins and their annotated locations for NP_001276558.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' coding region and lacks an alternate in-frame exon, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (7) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC068561, AC153836
      Consensus CDS
      CCDS71731.1
      UniProtKB/TrEMBL
      D3YUM7
      Related
      ENSMUSP00000000674.7, ENSMUST00000000674.13
      Conserved Domains (1) summary
      pfam04184
      Location:4507
      ST7; ST7 protein
    7. NM_022332.3NP_071727.2  suppressor of tumorigenicity 7 protein isoform 1

      See identical proteins and their annotated locations for NP_071727.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AK079107, BC108418, BY479263
      Consensus CDS
      CCDS19927.1
      UniProtKB/TrEMBL
      D3YUM7
      Related
      ENSMUSP00000057326.8, ENSMUST00000053148.14
      Conserved Domains (1) summary
      cd11557
      Location:11498
      ST7; Suppression of tumorigenicity 7

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      17693579..17943022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241076.4XP_011239378.1  suppressor of tumorigenicity 7 protein isoform X1

      Conserved Domains (1) summary
      cd11557
      Location:1377
      ST7; Suppression of tumorigenicity 7

    RNA

    1. XR_004933617.1 RNA Sequence

    2. XR_868763.4 RNA Sequence

    3. XR_868764.4 RNA Sequence

    4. XR_003956242.2 RNA Sequence

    5. XR_377290.5 RNA Sequence

    6. XR_003956244.2 RNA Sequence

    7. XR_003956243.2 RNA Sequence

    8. XR_377291.5 RNA Sequence

    9. XR_003956245.2 RNA Sequence

    10. XR_003956246.2 RNA Sequence

    11. XR_003956247.2 RNA Sequence