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    bacA undecaprenyl pyrophosphate phosphatase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947551, updated on 3-Dec-2024

    Summary

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    Official Symbol
    bacA
    Official Full Name
    undecaprenyl pyrophosphate phosphatase
    Primary source
    ECOCYC:EG11665
    Locus tag
    b3057
    See related
    ASAP:ABE-0010034
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3047; uppP
    Summary
    BacA(UppP) encodes 75% of the cell's UppP activity. [More information is available at EcoGene: EG11665]. The purified BacA protein exhibits undecaprenyl pyrophosphate phosphatase activity, but not undecaprenol phosphokinase activity . [More information is available at EcoCyc: EG11665].
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    Genomic context

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    Sequence:
    NC_000913.3 (3203310..3204131, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative signal transduction protein (SH3 domain) Neighboring gene fused CCA tRNA nucleotidyltransferase/phosphohydrolase Neighboring gene dihydroneopterin aldolase Neighboring gene putative glycerol-3-phosphate acyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Membrane Topology and Biochemical Characterization of the Escherichia coli BacA Undecaprenyl-Pyrophosphate Phosphatase. Manat G, et al. PLoS One, 2015. PMID 26560897, Free PMC Article
    2. Periplasmic phosphorylation of lipid A is linked to the synthesis of undecaprenyl phosphate. Touzé T, et al. Mol Microbiol, 2008 Jan. PMID 18047581, Free PMC Article
    3. An Escherichia coli undecaprenyl-pyrophosphate phosphatase implicated in undecaprenyl phosphate recycling. Tatar LD, et al. Microbiology (Reading), 2007 Aug. PMID 17660416
    4. New members of the Escherichia coli sigmaE regulon identified by a two-plasmid system. Rezuchova B, et al. FEMS Microbiol Lett, 2003 Aug 8. PMID 12900013
    5. Identification of multiple genes encoding membrane proteins with undecaprenyl pyrophosphate phosphatase (UppP) activity in Escherichia coli. El Ghachi M, et al. J Biol Chem, 2005 May 13. PMID 15778224

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. all the different E. coli C55-PP phosphatases identified to date (BacA and PAP2, including PgpB, YbjG and LpxT) catalyze the dephosphorylation of C55-PP molecules on the same (outer) side of the plasma membrane
      Title: Membrane Topology and Biochemical Characterization of the Escherichia coli BacA Undecaprenyl-Pyrophosphate Phosphatase.
    2. there are multiple genes encoding membrane proteins with undecaprenyl pyrophosphate phosphatase (UppP) activity in Escherichia coli
      Title: Identification of multiple genes encoding membrane proteins with undecaprenyl pyrophosphate phosphatase (UppP) activity in Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    General protein information

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    Preferred Names
    undecaprenyl pyrophosphate phosphatase
    NP_417529.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3203310..3204131 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417529.1 undecaprenyl pyrophosphate phosphatase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417529.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A192CDA9, A0AA36L0M9
      Conserved Domains (1) summary
      PRK00281
      Location:3 → 273
      PRK00281; undecaprenyl-diphosphate phosphatase
    Nucleotide Protein
    Heading Accession and Version

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