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    Kiaa0586 KIAA0586 homolog [ Rattus norvegicus (Norway rat) ]

    Gene ID: 690035, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kiaa0586provided by RGD
    Official Full Name
    KIAA0586 homologprovided by RGD
    Primary source
    RGD:1585176
    See related
    EnsemblRapid:ENSRNOG00000008244 AllianceGenome:RGD:1585176
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in smoothened signaling pathway. Predicted to act upstream of or within cilium assembly and regulation of establishment of protein localization. Predicted to be located in centrosome. Predicted to be active in centriole and ciliary basal body. Human ortholog(s) of this gene implicated in Joubert syndrome 23 and short-rib thoracic dysplasia 14 with polydactyly. Orthologous to human KIAA0586 (KIAA0586). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 90.7), Adrenal (RPKM 62.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kiaa0586 in Genome Data Viewer
    Location:
    6q24
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (95358682..95461911)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (89622711..89725951)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (93562775..93667857)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene proteasome 20S subunit alpha 3 Neighboring gene AT-rich interaction domain 4A Neighboring gene translocase of outer mitochondrial membrane 20 like Neighboring gene translocase of inner mitochondrial membrane 9 Neighboring gene dishevelled-binding antagonist of beta-catenin 1 Neighboring gene similar to ATPase inhibitory factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Talpid3 gene (KIAA0586) encodes a centrosomal protein that is essential for primary cilia formation. Yin Y, et al. Development, 2009 Feb. PMID 19144723, Free PMC Article
    2. Generation of mice with functional inactivation of talpid3, a gene first identified in chicken. Bangs F, et al. Development, 2011 Aug. PMID 21750036, Free PMC Article
    3. The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly. Kobayashi T, et al. J Cell Biol, 2014 Jan 20. PMID 24421332, Free PMC Article
    4. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in smoothened signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein TALPID3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427161.1 → NP_001414090.1  protein TALPID3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      Related
      ENSRNOP00000039101.7, ENSRNOT00000050558.8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      95358682..95461911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039113227.2 → XP_038969155.1  protein TALPID3 isoform X1

      UniProtKB/TrEMBL
      F1LZT2
      Conserved Domains (1) summary
      pfam15324
      Location:116 → 1357
      TALPID3; Hedgehog signalling target

    2. XM_063262508.1 → XP_063118578.1  protein TALPID3 isoform X4

    3. XM_063262506.1 → XP_063118576.1  protein TALPID3 isoform X2

    4. XM_063262509.1 → XP_063118579.1  protein TALPID3 isoform X5

      UniProtKB/TrEMBL
      D4A3M6
      Related
      ENSRNOP00000011056.8, ENSRNOT00000011056.9

    5. XM_063262511.1 → XP_063118581.1  protein TALPID3 isoform X7

    6. XM_063262510.1 → XP_063118580.1  protein TALPID3 isoform X6

    7. XM_039113225.2 → XP_038969153.1  protein TALPID3 isoform X1

      UniProtKB/TrEMBL
      F1LZT2
      Related
      ENSRNOP00000102639.1, ENSRNOT00000125521.1
      Conserved Domains (1) summary
      pfam15324
      Location:116 → 1357
      TALPID3; Hedgehog signalling target

    8. XM_039113229.2 → XP_038969157.1  protein TALPID3 isoform X3

      Conserved Domains (1) summary
      pfam15324
      Location:116 → 1332
      TALPID3; Hedgehog signalling target

    9. XM_063262507.1 → XP_063118577.1  protein TALPID3 isoform X3

    10. XM_039113226.2 → XP_038969154.1  protein TALPID3 isoform X1

      UniProtKB/TrEMBL
      F1LZT2
      Conserved Domains (1) summary
      pfam15324
      Location:116 → 1357
      TALPID3; Hedgehog signalling target

    RNA

    1. XR_010052151.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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