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    Pou6f1 POU domain, class 6, transcription factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 19009, updated on 3-Dec-2024

    Summary

    Official Symbol
    Pou6f1provided by MGI
    Official Full Name
    POU domain, class 6, transcription factor 1provided by MGI
    Primary source
    MGI:MGI:102935
    See related
    Ensembl:ENSMUSG00000009739 AllianceGenome:MGI:102935
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Emb; cns-1; 2310038G18Rik
    Summary
    Enables sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including genitourinary system; limb; nervous system; sensory organ; and skeletal musculature. Orthologous to human POU6F1 (POU class 6 homeobox 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in thymus adult (RPKM 22.0), cortex adult (RPKM 16.2) and 23 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pou6f1 in Genome Data Viewer
    Location:
    15 F1; 15 56.35 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (100473199..100497949, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (100575318..100600061, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene cysteine-serine-rich nuclear protein 2 Neighboring gene STARR-seq mESC enhancer starr_39756 Neighboring gene transcription factor CP2 Neighboring gene STARR-positive B cell enhancer ABC_E7419 Neighboring gene STARR-seq mESC enhancer starr_39757 Neighboring gene STARR-positive B cell enhancer ABC_E4150 Neighboring gene RIKEN cDNA C330013E15 gene Neighboring gene STARR-positive B cell enhancer ABC_E610 Neighboring gene DAZ associated protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    POU domain, class 6, transcription factor 1
    Names
    octamer-binding transcription factor EMB
    transcription regulatory protein MCP-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304965.2NP_001291894.1  POU domain, class 6, transcription factor 1 isoform 1

      See identical proteins and their annotated locations for NP_001291894.1

      Status: VALIDATED

      Source sequence(s)
      AC123724
      Consensus CDS
      CCDS79411.1
      UniProtKB/TrEMBL
      Q5U4D4, Q6X2S0
      Related
      ENSMUSP00000073504.7, ENSMUST00000073837.13
      Conserved Domains (2) summary
      pfam00046
      Location:512565
      Homeobox; Homeobox domain
      cl22952
      Location:414488
      Pou; Pou domain - N-terminal to homeobox domain
    2. NM_001404294.1NP_001391223.1  POU domain, class 6, transcription factor 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC123724
      UniProtKB/TrEMBL
      Q6X2S0
    3. NM_001404295.1NP_001391224.1  POU domain, class 6, transcription factor 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC123724
      UniProtKB/Swiss-Prot
      Q07916, Q91XK3
    4. NM_001404296.1NP_001391225.1  POU domain, class 6, transcription factor 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC123724
      UniProtKB/Swiss-Prot
      Q07916, Q91XK3
    5. NM_001404297.1NP_001391226.1  POU domain, class 6, transcription factor 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC123724
      UniProtKB/Swiss-Prot
      Q07916, Q91XK3
      Related
      ENSMUSP00000145707.2, ENSMUST00000176271.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      100473199..100497949 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248418.2XP_030104278.1  POU domain, class 6, transcription factor 1 isoform X5

      UniProtKB/TrEMBL
      Q6X2S0
      Conserved Domains (3) summary
      PHA03247
      Location:98390
      PHA03247; large tegument protein UL36; Provisional
      pfam00046
      Location:511565
      Homeobox; Homeobox domain
      cl22952
      Location:413487
      Pou; Pou domain - N-terminal to homeobox domain
    2. XM_006520614.5XP_006520677.1  POU domain, class 6, transcription factor 1 isoform X8

      Conserved Domains (3) summary
      PRK12323
      Location:46263
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam00046
      Location:337391
      Homeobox; Homeobox domain
      cl22952
      Location:287313
      Pou; Pou domain - N-terminal to homeobox domain
    3. XM_017316508.3XP_017171997.1  POU domain, class 6, transcription factor 1 isoform X6

      UniProtKB/TrEMBL
      Q6X2S0
      Conserved Domains (3) summary
      PHA03247
      Location:58378
      PHA03247; large tegument protein UL36; Provisional
      pfam00046
      Location:478532
      Homeobox; Homeobox domain
      cl22952
      Location:380454
      Pou; Pou domain - N-terminal to homeobox domain
    4. XM_017316509.2XP_017171998.1  POU domain, class 6, transcription factor 1 isoform X7

      Conserved Domains (1) summary
      PHA03247
      Location:48452
      PHA03247; large tegument protein UL36; Provisional
    5. XM_030248417.2XP_030104277.1  POU domain, class 6, transcription factor 1 isoform X3

      UniProtKB/TrEMBL
      Q6X2S0
      Conserved Domains (3) summary
      PHA03247
      Location:31406
      PHA03247; large tegument protein UL36; Provisional
      pfam00046
      Location:527581
      Homeobox; Homeobox domain
      cl22952
      Location:429503
      Pou; Pou domain - N-terminal to homeobox domain
    6. XM_006520609.4XP_006520672.1  POU domain, class 6, transcription factor 1 isoform X2

      UniProtKB/TrEMBL
      Q6X2S0
      Conserved Domains (3) summary
      PHA03247
      Location:50424
      PHA03247; large tegument protein UL36; Provisional
      pfam00046
      Location:545599
      Homeobox; Homeobox domain
      cl22952
      Location:447521
      Pou; Pou domain - N-terminal to homeobox domain
    7. XM_030248416.1XP_030104276.1  POU domain, class 6, transcription factor 1 isoform X1

      UniProtKB/TrEMBL
      Q6X2S0
      Conserved Domains (3) summary
      PHA03247
      Location:48425
      PHA03247; large tegument protein UL36; Provisional
      pfam00046
      Location:546600
      Homeobox; Homeobox domain
      cl22952
      Location:448522
      Pou; Pou domain - N-terminal to homeobox domain
    8. XM_006520608.4XP_006520671.1  POU domain, class 6, transcription factor 1 isoform X1

      UniProtKB/TrEMBL
      Q6X2S0
      Conserved Domains (3) summary
      PHA03247
      Location:48425
      PHA03247; large tegument protein UL36; Provisional
      pfam00046
      Location:546600
      Homeobox; Homeobox domain
      cl22952
      Location:448522
      Pou; Pou domain - N-terminal to homeobox domain
    9. XM_030248419.1XP_030104279.1  POU domain, class 6, transcription factor 1 isoform X9

      Conserved Domains (3) summary
      PRK14951
      Location:41158
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional
      pfam00046
      Location:267321
      Homeobox; Homeobox domain
      cl22952
      Location:169243
      Pou; Pou domain - N-terminal to homeobox domain
    10. XM_036159263.1XP_036015156.1  POU domain, class 6, transcription factor 1 isoform X10

      Conserved Domains (2) summary
      PHA03247
      Location:58295
      PHA03247; large tegument protein UL36; Provisional
      PRK07994
      Location:170272
      PRK07994; DNA polymerase III subunits gamma and tau; Validated

    RNA

    1. XR_004938810.1 RNA Sequence

      Related
      ENSMUST00000176140.8
    2. XR_004938809.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_010127.3: Suppressed sequence

      Description
      NM_010127.3: This RefSeq was removed because currently there is insufficient support for the transcript and protein.